Abstract:Iron plays a critical role in brain development and physiology, cytoplasmic protein function, and mitochondrial reactions. Brain iron levels are regulated tightly, and pathologies can result from both iron deficiency (learning and memory deficits, neuronal and dendritic developmental alterations, impaired myelin function, and abnormal neurotransmitter regulation) and iron overload (free radical production and oxidative stress, as proposed for Parkinson and Alzheimer diseases as well as rare genetic disorders o… Show more
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