Iron homeostasis in older adults: balancing nutritional requirements and health risks

Zeidan, Rola S.; Martenson, Matthew; Tamargo, Javier A.; McLaren, Christian; Ezzati, Armin; Lin, Yi; Yang, Jae Jeong; Yoon, Hyung-Suk; McElroy, Taylor; Collins, James F.; Leeuwenburgh, Christiaan; Mankowski, Robert T.; Anton, Stephen

doi:10.1016/j.jnha.2024.100212

Cited by 6 publications

(1 citation statement)

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“…Conversely, iron toxicity is also a concern, leading to the generation of reactive oxygen species through the Fenton reaction that accelerate oxidative damage and contribute to age-related pathologies. [ 29 ] In particular, iron overload within mitochondria has been associated with biomolecular oxidative damage observed in aged organisms. [ 30 ] Thus, alterations in iron homeostasis have been linked to several diseases of aging, including Alzheimer disease, Parkinson disease, and atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Unveiling the causal relationship between circulating levels of micronutrients and risk of facial aging: A Mendelian randomization study

Zhu,

Cai,

Cai

et al. 2024

Medicine

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Facial aging involves a continuous sequence of complex, interrelated events that impact numerous facial tissues. The aim of the study was to elucidate the casual relationship between circulating micronutrients and risk of facial aging. A two-sample Mendelian randomization analysis was performed using genetic data from genome-wide association studies. The inverse-variance weighted method is used for causal effect estimation, and additional tools such as Mendelian randomization-Egger, weighted median, simple mode, and weighted mode were used to refine the analysis. We conducted an in-depth examination of the correlation between several micronutrient blood levels and the risk of facial aging, and identified 3 key micronutrients (selenium, carotene, and iron) that may have a significant impact on skin health. Inverse-variance weighted results indicate that selenium levels were positively correlated with the risk of facial aging (odds ratio [OR] 1.005, P = .027), while a negative causal effect of carotene (OR 0.979, P = .024) and iron (OR 0.976, P = .009) on age-related facial alterations was observed. This study offers a new and insightful perspective on the current understanding of antiaging strategies, particularly the importance of appropriate consumption of essential micronutrients to maintain healthy skin condition.

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Section: Discussionmentioning

confidence: 99%