Iron(III)-Catalysed Povarov Cyclisation for the Synthesis of Fused Dibenzo[b,f][1,7]naphthyridine Embedded Arylpyrrolo Scaffolds

Abstract

An FeCl3 catalyzed Povarov reaction for the efficient synthesis of dibenzo[b,f]-[1,7]-naphthyridines utilizing 2-pyrolecarbaldehyde-2`-alkynylaryl and aryl amine in excellent yields. The essential features of the present strategy are; easy preparation of substrates, broad substrate scope, mild reaction conditions, high atom economy and yields in the presence of environmentally friendly iron catalysis.