Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T1 MRI Contrast in Liver Cell Lines

Krungchanuchat, Saowalak; Thongtem, Titipun; Thongtem, Somchai; Pilapong, Chalermchai

doi:10.1038/s41598-018-25108-1

Cited by 51 publications

(51 citation statements)

References 54 publications

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“…Indeed, they were highly stable for transchelation and transmetalization. 16 Our method for preparing the Fe-TA NPs was simple and reproducible without having to use expensive equipment and reagents, which allows us to apply this method for an industrial application.…”

Section: Resultsmentioning

confidence: 98%

“…PBS buffer (pH 7.4) was chosen as the reaction medium because this condition is suitable to form nanosized Fe-TA complexes with predominantly Tris-coordinated structure that are more stable structures. 16 Schematic illustration for Fe-TA NPs preparation and typical characteristics of Fe-TA NPs are shown in Fig. S1.…”

Section: Resultsmentioning

confidence: 99%

“…Fe-TA NPs were synthesized according to our previous work with some modications. 16 In brief, 10 mmol of tannic acid and 30 of mmol of FeCl 3 $6H 2 O were added to 300 ml of phosphatebuffered saline (PBS). The Fe-TA NPs were suddenly obtained, appeared as red-wine color.…”

Section: Fe-ta Nps Synthesismentioning

confidence: 99%

“…Examples of their benecial properties are that they have small size, high MRI relaxivity, high stability, good water solubility, and demonstrate high uptake efficiency in tumor cells with capability of being responsive to abnormal microenvironments. 15,16 Because of their good physico-chemical properties along with their ease of scale-up reproducibility, Fe-TA NPs could offer great feasibility as a low-cost clinical MRI contrast agent with many advantageous characteristics for use in liver cancer diagnosis. In this research, we aimed to investigate the feasibility of using irontannic nanoparticles to enhance MRI contrast of rat liver with preneoplastic lesions.…”

Section: Introductionmentioning

confidence: 99%

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MRI contrast enhancement of liver pre-neoplasia using iron–tannic nanoparticles

et al. 2020

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Fe-ta Nps Synthesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MRI contrast enhancement of liver pre-neoplasia using iron–tannic nanoparticles

et al. 2020

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“…HepG2 human liver cancer cells, MCF-7 human breast cancer cells, and A549 human lung cancer cells treated with PGG increased the LC3-II level, a sign of autophagy [81]. A new molecular nanoparticle based on iron(III)-tannic complexes (Fe-TA NPs) induced autophagic cell death in HepG2 cells via upregulation of LC3 mRNA expression and autophagosome formation [83]. Autophagic responses were observed in human DU145 and PC-3 prostate cancer xenografts in nude mice detected by the formation of autophagosomes.…”

Section: Gallotannin and Autophagymentioning

confidence: 99%

Cell Death Mechanisms of the Promising Anticancer Compound Gallotannin

Houssein¹,

Gali‐Muhtasib²

2020

Programmed Cell Death

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The polyphenolic hydrolyzable tannin, gallotannin (GT), also known as tannic acid, possesses interesting anticarcinogenic properties. An evidence from experimental studies suggests that GT is effective against multiple cancer types. Gallotannin has been shown to induce programmed cell death in a wide variety of cancers including colon, breast, prostate, and liver, among others. Apoptosis, cellular senescence, autophagy, and necrosis are the main mechanisms by which GT can suppress cancer progression. In addition, GT is a potent inhibitor of many proliferation pathways. Herein, this chapter provides a summary of our current knowledge about GT's programmed cell death mechanisms against cancer.

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Understanding Nanomaterial–Liver Interactions to Facilitate the Development of Safer Nanoapplications

Chen

Xia

2022

Advanced Materials

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vaccines, and drug carriers (Figure 1). The functional advantages of NMs are derived from their unique physical and chemical properties. [1,[4][5][6] Among all the NMs, metallic NMs including metal and metal oxides (MOx) nanoparticles (NPs), such as Ag and Au NPs, transition-metal oxides (TMOs, e.g., SiO 2 , Co 3 O 4 , and Mn 2 O 3 ), and rare-earth oxides REOs (e.g., Gd 2 O 3 , La 2 O 3 , and Y 2 O 3 ) NPs, are among the most produced NMs worldwide. Also, they are widely used in consumer products such as dietary supplements, fuel additives, cosmetics, bioimaging, and drug carriers, etc. due to their properties such as small size, high surface area, controlled particle shape as well as superior mechanical, electronic, optical, and magnetic properties. [7][8][9] For example, SiO 2 NPs have been applied in the theranostic fields, including bioimaging and targeted drug delivery. [7] In addition, the popularity of carbon nanomaterials (CNMs) including 0D fullerenes, 1D carbon nanotubes (CNTs), and 2D graphene-based nanoparticles (GBN) including graphene, graphene oxide (GO), and reduced graphene oxide (rGO) has been on the rise for their applications in battery, electronics, drug delivery, bio-sensing, bio-imaging, and tissue engineering due to their large surface area, diverse surface functional groups, excellent optical property, and efficient drug-loading capacity. [10][11][12][13][14][15][16] For example, an advanced NMsbased biosensing platform based on rGO has been developed to detect the coronavirus disease 2019 (COVID-19) antibodies within seconds. [17] Additionally, a form of nanostructured cellulose (nanocellulose), including cellulose nanocrystal (CNC) and cellulose nanofiber (CNF) has been increasingly considered for applications in papermaking, coatings, food, nanocomposite formulations and reinforcement, and biomedical fields (e.g., wound dressing) due to its biocompatibility, outstanding mechanical, chemical, and rheological properties. [18,19] Also 2D transition metal dichalcogenides (TMDs) (including MoS 2 and BN) with high surface area and free surface energy levels are increasingly being used for commercial applications in energy generation, sensors, catalysis, electronics, and biomedicine fields. [13,[20][21][22] Similarly, organic NPs (including lipid, liposome, polymer, micelle, dendrimer, and protein/peptide-based NPs) have been widely used in diagnosis, drug delivery, bioimaging, and cancer therapy because of their facile synthesis and chemical modification, self-assembly, biocompatibility, and biodegradability. [23][24][25] The global market value of NMs will be expected to reach US$ 125 billion marks by 2024. [26] The widespread Nanomaterials (NMs) are widely used in commercial and medical products, such as cosmetics, vaccines, and drug carriers. Exposure to NMs via various routes such as dermal, inhalation, and ingestion has been shown to gain access to the systemic circulation, resulting in the accumulation of NMs in the liver. The unique organ structures and blood flow features facilitate...

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Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T1 MRI Contrast in Liver Cell Lines

Cited by 51 publications

References 54 publications

MRI contrast enhancement of liver pre-neoplasia using iron–tannic nanoparticles

MRI contrast enhancement of liver pre-neoplasia using iron–tannic nanoparticles

Cell Death Mechanisms of the Promising Anticancer Compound Gallotannin

Understanding Nanomaterial–Liver Interactions to Facilitate the Development of Safer Nanoapplications

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