Iron in typical and atypical parkinsonism – Mössbauer spectroscopy and MRI studies

Kulinski, Radoslaw; Bauminger, E. R.; Friedman, Andrzej; Duda, Przemysław; Gałązka-Friedman, J.

doi:10.1007/s10751-016-1234-4

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…The coefficient of asymmetry of the Mössbauer spectra was significantly higher in GP from PSP than in control GP, which may reflect the different crystallization of iron within ferritin in PSP [ 200 ]. In addition, the T1 and T2 relaxation times determined by MRI indicated a dependence of T2 in PSP-GP on factors other than just the concentration of iron [ 201 ]. The different behaviour of T2 in PD and PSP may thus be related to different mechanisms of neurodegeneration in these diseases [ 201 ].…”

Section: Various Neurodegenerative Factorsmentioning

confidence: 99%

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Mechanisms of Neurodegeneration in Various Forms of Parkinsonism—Similarities and Differences

Koziorowski

Figura

Milanowski

et al. 2021

Cells

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Parkinson's disease (PD), dementia with Lewy body (DLB), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA) belong to a group of neurodegenerative diseases called parkinsonian syndromes. They share several clinical, neuropathological and genetic features. Neurodegenerative diseases are characterized by the progressive dysfunction of specific populations of neurons, determining clinical presentation. Neuronal loss is associated with extra- and intracellular accumulation of misfolded proteins. The parkinsonian diseases affect distinct areas of the brain. PD and MSA belong to a group of synucleinopathies that are characterized by the presence of fibrillary aggregates of α-synuclein protein in the cytoplasm of selected populations of neurons and glial cells. PSP is a tauopathy associated with the pathological aggregation of the microtubule associated tau protein. Although PD is common in the world's aging population and has been extensively studied, the exact mechanisms of the neurodegeneration are still not fully understood. Growing evidence indicates that parkinsonian disorders to some extent share a genetic background, with two key components identified so far: the microtubule associated tau protein gene (MAPT) and the α-synuclein gene (SNCA). The main pathways of parkinsonian neurodegeneration described in the literature are the protein and mitochondrial pathways. The factors that lead to neurodegeneration are primarily environmental toxins, inflammatory factors, oxidative stress and traumatic brain injury.

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Section: Various Neurodegenerative Factorsmentioning

confidence: 99%

“…In addition, the T1 and T2 relaxation times determined by MRI indicated a dependence of T2 in PSP-GP on factors other than just the concentration of iron [ 201 ]. The different behaviour of T2 in PD and PSP may thus be related to different mechanisms of neurodegeneration in these diseases [ 201 ].…”

Section: Various Neurodegenerative Factorsmentioning

confidence: 99%

Mechanisms of Neurodegeneration in Various Forms of Parkinsonism—Similarities and Differences

Koziorowski

Figura

Milanowski

et al. 2021

Cells

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“…We decided to compare relaxation times from different brain structures (SN, globus pallidus, and hippocampal cortex) in living patients with Parkinson's disease, atypical parkinsonism-progressive supranuclear palsy and controls with the concentration of iron measured by Mössbauer spectroscopy. The results of MS were taken from our previous published studies of brain samples of the same structures of patients with the same diagnoses and controls [17]. A perfect correlation between R1 (1/T1) time and the concentration of iron in brain samples was found, the coefficient of correlation being 0.945.…”

Section: Mössbauer Spectroscopy and Magnetic Resonance Imagingmentioning

confidence: 99%

Mössbauer spectroscopy and the understanding of the role of iron in neurodegeneration

Friedman

Gałązka-Friedman

2017

Hyperfine Interact

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The possible role of iron in neurodegeneration may be related to the oxidative stress, triggered by Fenton reaction. In this reaction hydroxyl free radical production is generated by divalent iron. Motor symptoms of Parkinson's disease depend on the destruction of substantia nigra (SN). As the substantive questions were: 1/ what is the concentration of iron in the samples, 2/ what is the proportion of divalent vs. trivalent iron in the samples, and 3/ what is the iron-binding compound, it seemed appropriate to use Mössbauer spectroscopy to answer those questions. We found no difference in the concentration of total iron between PD and control, with the ratio of iron in PD vs. control being 1.00 ± 0.13. The divalent iron could not exceed 5% of the total iron. The main iron-binding compound in SN, both in PD and control is ferritin. Our further studies of ferritin in parkinsonian SN demonstrated a decrease, compared to control, of L-ferritin involved in the storage of iron within ferritin. This could allow an efflux of iron from the ferritin shell and an increase of nonferritin iron in PD SN, which was confirmed by us. Mössbauer studies in Alzheimer showed slightly higher concentration of iron in hippocampal cortex with significantly higher concentrations of L and H ferritins compared to control. In atypical parkinsonism, progressive supranuclear palsy, higher concentration of iron was found in globus pallidus and SN compared to control. Mössbauer spectroscopy may play crucial role in further studies of human neurodegeneration.

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Applications of Mössbauer Spectroscopy in Biomedical Research

Оштрах

2018

Cell Biochem Biophys

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A brief review on the applications of Mössbauer spectroscopy in biomedical research discusses the results of more than fifty years of experience in this field. Basing on the numerous results the main directions of biomedical applications of Mössbauer spectroscopy are considered as follows: 1) studies of the quantitative changes of iron-containing biomolecules related to pathological processes; 2) studies of the qualitative changes in iron-containing biomolecules related to pathological processes; 3) studies of the effect of various environmental factors (physical, chemical, and biological) on iron-containing biomolecules; 4) studies of metabolic processes by means of analysis of the Mössbauer nuclides pathways in organisms; 5) studies of dynamic processes; 6) studies of pharmaceutical compounds and blood substitutes containing Mössbauer nuclides; 7) miscellaneous studies. Some examples of biomedical research using Fe,Co, Sn,Sm, and Au Mössbauer nuclides are presented.

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Iron in typical and atypical parkinsonism – Mössbauer spectroscopy and MRI studies

Cited by 5 publications

References 16 publications

Mechanisms of Neurodegeneration in Various Forms of Parkinsonism—Similarities and Differences

Mechanisms of Neurodegeneration in Various Forms of Parkinsonism—Similarities and Differences

Mössbauer spectroscopy and the understanding of the role of iron in neurodegeneration

Applications of Mössbauer Spectroscopy in Biomedical Research

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