Iron-Induced Oxidative Stress in Erythrocyte Membranes of Non-Insulin-Dependent Diabetic Nigerians

Okunade, Gbolahan; Odunuga, Odutayo O.; Olorunsogo, Olufunso O.

doi:10.1023/a:1020113121995

Cited by 6 publications

(12 citation statements)

References 36 publications

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“…The detection of significant amounts of lipid breakdown products in a membrane after oxidative stress induced by incubation gives the impression that ROS capable of initiating peroxidation of membrane phospholipids are being generated in the membrane. 6 Increased production of MDA has also been demonstrated in the erythrocyte membranes of diabetic patients 18,19 and high-lipid peroxides levels are also observed in diabetic rats. 20 It is suggested that increased MDA levels leading to damage in erythrocyte cells membrane is important not only for the progress of diabetes but also in the development of diabetic complications.…”

Section: Discussionmentioning

confidence: 95%

“…Studies have shown increased level of plasma lipid in diabetic individuals as compared to their control. 6,7 It is well known that a number of enzymatic systems protect cells from the damage caused by excessive production of ROS. These systems include superoxide dismutase (SOD) in the cytosol that convert superoxide into hydrogen peroxide, together with the glutathione peroxidase (GPX) and catalase (CAT) enzymes in the cytosol and peroxisomes that convert hydrogen peroxide to water.…”

Section: Introductionmentioning

confidence: 99%

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Lipid Peroxidation and Serum Antioxidant Enzymes in Patients with Type 2 Diabetes Mellitus

Ahmed

Naqvi

Shafiq

2006

Annals of the New York Academy of Sciences

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Diabetes mellitus is characterized by fasting hyperglycemia, with both type 1 and type 2 diabetes. Persons are also known to be prone to develop complications related to elevated blood glucose concentrations, including atherosclerosis, retinal damage, cataract, and neuropathy. Hyperglycemia may also result in increased production of the reactive oxygen species within numerous biochemical pathways that have the potential to initiate changes in endothelial function. This article demonstrates the presence of lipid peroxidation products in the red cell membranes of type 2 diabetic patients compared to the normal subjects. These membranes are more susceptible to exogenous oxidative stress than those of normal healthy individuals. Significantly higher activities of antioxidant enzymes, namely, serum peroxidase, superoxide dismutase (SOD), and catalase (CAT) were found in type 2 diabetic patients as compared to control. This study led us to conclude that elevated levels of glucose induce oxidative stress that is ultimately reflected by the increased malondialdehyde (MDA) levels in erythrocyte ghost membranes of diabetic patients. Hyperglycemia also induced an increase in antioxidant enzymes and a relationship seems to exist between diabetic complications and elevated levels of these enzymes. It is suggested that these antioxidant enzymes may be considered as markers for vascular injury.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Lipid Peroxidation and Serum Antioxidant Enzymes in Patients with Type 2 Diabetes Mellitus

Ahmed

Naqvi

Shafiq

2006

Annals of the New York Academy of Sciences

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“…Furthermore, a study from Okunade et al . has shown that the presence of significant levels of non-heme iron in the non-insulin-dependent diabetes mellitus subjects is an indication of the potential for iron-catalysed production of hydroxyl and other toxic radicals could cause continues oxidative stress and tissue damage [48]. Therefore, altered non-heme iron levels in aged rats may be a recognized age-related phenomenon which contributes to oxidative stress and muscle atrophy.…”

Section: Discussionmentioning

confidence: 99%

Iron Accumulation with Age, Oxidative Stress and Functional Decline

et al. 2008

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Identification of biological mediators in sarcopenia is pertinent to the development of targeted interventions to alleviate this condition. Iron is recognized as a potent pro-oxidant and a catalyst for the formation of reactive oxygen species in biological systems. It is well accepted that iron accumulates with senescence in several organs, but little is known about iron accumulation in muscle and how it may affect muscle function. In addition, it is unclear if interventions which reduced age-related loss of muscle quality, such as calorie restriction, impact iron accumulation. We investigated non-heme iron concentration, oxidative stress to nucleic acids in gastrocnemius muscle and key indices of sarcopenia (muscle mass and grip strength) in male Fischer 344 X Brown Norway rats fed ad libitum (AL) or a calorie restricted diet (60% of ad libitum food intake starting at 4 months of age) at 8, 18, 29 and 37 months of age. Total non-heme iron levels in the gastrocnemius muscle of AL rats increased progressively with age. Between 29 and 37 months of age, the non-heme iron concentration increased by approximately 200% in AL-fed rats. Most importantly, the levels of oxidized RNA in gastrocnemius muscle of AL rats were significantly increased as well. The striking age-associated increase in non-heme iron and oxidized RNA levels and decrease in sarcopenia indices were all attenuated in the calorie restriction (CR) rats. These findings strongly suggest that the age-related iron accumulation in muscle contributes to increased oxidative damage and sarcopenia, and that CR effectively attenuates these negative effects.

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“…Alterations in antioxidant defense mechanism during diabetes especially in relation to changes in the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase have been very well reported (Durak et al 1994). It has also been reported that there is an increased level of lipid peroxidation during diabetes, which is indicative of cellular damage (Okunade et al 1999;Sajid and Naqvi 2005).…”

Section: Introductionmentioning

confidence: 95%

“…1994). It has also been reported that there is an increased level of lipid peroxidation during diabetes, which is indicative of cellular damage (Okunade et al. 1999; Sajid and Naqvi 2005).…”

Section: Introductionmentioning

confidence: 97%

Effect of Butyric Acid Supplementation on Serum and Renal Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetic Rats

Kumar

Chougala

Nandini

et al. 2010

Journal of Food Biochemistry

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Reactive oxygen metabolites, which are constant products of normal aerobic cell metabolism, play a key role in worsening the pathophysiological complications of diabetes. The present investigation was aimed at understanding the effect of butyric acid supplementation along with wheatbran and guar gum on serum and renal antioxidant enzyme activities and lipid peroxidation in streptozotocin (STZ)‐induced diabetic rats. Activities of superoxide dismutase, catalase, glutathione peroxidase were evaluated in serum and kidney of control and experimental rats. Results clearly showed that the altered activity of the enzymes during diabetes was significantly ameliorated by butyric acid (500 mg/kg body weight/day) supplementation compared with other experimental groups. Further, the increased lipid peroxidation in serum and kidney of diabetic rats was also significantly reduced in butyric acid‐supplemented diabetic rats. The study led us to conclude that butyric acid exert antioxidant property, thereby minimizing oxidative stress induced diabetes and its related complications. PRACTICAL APPLICATIONS Butyric acid – a product of dietary fiber fermentation – is a four‐carbon fatty acid, which has wide range of application in disease management. This product is involved in various physiological functions of body like cell differentiation, apoptosis, colonic homeostasis, histone acetylation, etc. It is also known to decrease the incidence of bowel cancer and some of its analogues are shown to selectively improve glucose‐stimulated insulin release and glucose tolerance in both normal and diabetic rats. This study aims to evaluate the beneficial effects of butyric acid supplementation on oxidative stress‐induced diabetic complications in rats.

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Iron-Induced Oxidative Stress in Erythrocyte Membranes of Non-Insulin-Dependent Diabetic Nigerians

Cited by 6 publications

References 36 publications

Lipid Peroxidation and Serum Antioxidant Enzymes in Patients with Type 2 Diabetes Mellitus

Lipid Peroxidation and Serum Antioxidant Enzymes in Patients with Type 2 Diabetes Mellitus

Iron Accumulation with Age, Oxidative Stress and Functional Decline

Effect of Butyric Acid Supplementation on Serum and Renal Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetic Rats

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