Iron–manganese: new class of metallic degradable biomaterials prepared by powder metallurgy

Hermawan, Hendra; Alamdari, Houshang; Mantovani, Diego; Dubé, D.

doi:10.1179/174329008x284868

Cited by 250 publications

(175 citation statements)

References 32 publications

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“…Therefore, our research group has developed an iron-manganese alloy through a powder metallurgical process. It was found that 35% manganese, here after denoted simply as alloy, showed comparable mechanical properties to that of the stainless steel [5].…”

Section: Introductionmentioning

confidence: 98%

“…Several materials have been reported as potential degradable metallic materials (DMMs) for cardiovascular stent application including pure iron [4], Fe-35Mn alloy [5], magnesium alloy [6][7], and others. For cardiovascular stent application, iron based materials present suitable ductility compared to that of magnesium-based materials.…”

Section: Introductionmentioning

confidence: 99%

“…The maximum daily intake for iron and manganese is 40 mg and 10 mg respectively [13]. Hence, considering the in vitro degradation rate of the alloy, 0.44 mmpy [5], and the total weight of a single cardiovascular stent, 50-100 mg [10], systemic toxicity provoked by a cardiovascular stent caused by the alloy is unlikely. Notably interesting, a localized and transient toxicity achieved by the coronary stent has been viewed as beneficial in order to inhibit ISR after implantation [14].…”

Section: Introductionmentioning

confidence: 99%

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Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents

et al. 2013

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Iron based materials could constitute an interesting option for cardiovascular biodegradable stent applications due to their superior ductility compared to their counterparts-magnesium alloys. Since the predicted degradation rate of pure iron is considered slow, manganese (35% w/w), an alloying element for iron, was explored to counteract this problem through the powder metallurgy process . However, manganese presents a high cytotoxic potential, thus its effect on cells must first be established. Here, we explored a new method to investigate a degradable metallic material (DMM) by establishing the gene expression profile (GEP) of mouse 3T3 fibroblasts exposed to Fe-35Mn degradation products in order to better understand cell response to potentially cytotoxic DMM. Briefly, 3T3 cells were exposed to degradation products eluting through tissue culture insert filter (3 µm pore size) containing cytostatic amounts of 3.25 mg/ml of Fe-35Mn powder, 0,25 mg/ml of pure Mn powder or 5 mg/ml of pure iron powder for 24 hours. We then conducted a gene expression profiling study from these cells. Exposure of 3T3 cells to Fe-35Mn was associated with the up-regulation of 75 genes and down-regulation of 59 genes, while 126 were up-regulated and 76 down-regulated genes in presence of manganese. No genes were found regulated for the iron powder. When comparing the GEP of 3T3 fibroblasts in presence of Fe-35Mn and Mn, 68 up-regulated and 54 down-regulated genes were common. These results were confirmed by quantitative RT-PCR for a subset of these genes. This GEP study could provide clues about the mechanism behind degradation products effects on cells of the Fe-35Mn alloy and may help in the appraisal of its potential for DMM applications.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents

et al. 2013

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“…Among Mg-based alloys have been studied, include MgAl- (Heublein, 2003, Witte, 2005, Xin, 2007), MgRE-(Di Mario, 2004, Peeters, 2005, Witte, 2005, Waksman, 2006, Hänzi, 2009) and MgCa- (Zhang, 2008, Li, 2008 based alloys. Meanwhile, for Fe-based alloys, pure iron (Peuster, 2001, Peuster, 2006 and FeMn alloys (Hermawan, 2008, Schinhammer, 2009) have been investigated mainly for cardiovascular applications. Among the most advanced studies on biodegradable metals is the development of stents.…”

Section: Biodegradable Metalsmentioning

confidence: 99%

“…The Mg-based alloys include MgAl-, MgRE (rare earth)- (Witte, 2005), and MgCa-(Li, 2008) based alloys. Meanwhile, the Fe-based alloys include pure iron (Peuster, 2001) and Fe-Mn alloys (Hermawan, 2008). …”

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confidence: 99%

Metals for Biomedical Applications

Hermawan¹,

Ramdan²,

Djuansjah³

2011

Biomedical Engineering - From Theory to Applications

175

125

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Biomedical Engineering -From Theory to Applications 412 visible under X-ray imaging. Most of artificial implants are subjected to loads, either static or repetitive, and this condition requires an excellent combination of strength and ductility. This is the superior characteristic of metals over polymers and ceramics. Specific requirements of metals depend on the specific implant applications. Stents and stent grafts are implanted to open stenotic blood vessels; therefore, it requires plasticity for expansion and rigidity to maintain dilatation. For orthopaedic implants, metals are required to have excellent toughness, elasticity, rigidity, strength and resistance to fracture. For total joint replacement, metals are needed to be wear resistance; therefore debris formation from friction can be avoided. Dental restoration requires strong and rigid metals and even the shape memory effect for better results. In overall, the use of biomaterials in clinical practice should be approved by an authoritative body such as the FDA (United States Food and Drug Administration). The proposed biomaterial will be either granted Premarket Approval (PMA) if substantially equivalent to o n e u s e d b e f o r e F D A l e g i s l a t i o n o f 1 9 7 6 , o r h a s t o g o t h r o u g h a s e r i e s o f g u i d e d biocompatibility assessment. Common metals used for biomedical devicesUp to now, the three most used metals for implants are stainless steel, CoCr alloys and Ti alloys. The first stainless steel used for implants contains ~18wt% Cr and ~8wt% Ni makes it stronger than the steel and more resistant to corrosion. Further addition of molybdenum (Mo) has improved its corrosion resistance, known as type 316 stainless steel. Afterwards, the carbon (C) content has been reduced from 0.08 to 0.03 wt% which improved its corrosion resistance to chloride solution, and named as 316L. Titanium is featured by its light weight. Its density is only 4.5g/cm 3 compared to 7.9g/cm 3 for 316 stainless steel and 8.3g/cm 3 for cast CoCrMo alloys (Brandes and Brook, 1992). Ti and its alloys, i.e. Ti6Al4V are known for their excellent tensile strength and pitting corrosion resistance. Titanium alloyed with Ni, i.e. Nitinol, forms alloys having shape memory effect which makes them suitable in various applications such as dental restoration wiring. In dentistry, precious metals and alloys often used are Au, Ag, Pt and their alloys. They possess good castability, ductility and resistance to corrosion. Included into dental alloys are AuAgCu system, AuAgCu with the addition of Zn and Sn known as dental solder, and AuPtPd system used for porcelain-fused-to-metal for teeth repairs. CoCr alloys have been utilised for many decades in making artificial joints. They are generally known for their excellent wear resistance. Especially the wrought CoNiCrMo alloy has been used for making heavily loaded joints such as ankle implants (Figure 1). Other metals used for implants include tantalum (Ta), amorphous alloys and biodegradable metals. Tantalum which has excell...

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Absorbable Filament Technologies: Wire‐Drawing to Enable Next‐Generation Medical Devices

Griebel¹,

Schaffer²

2016

Magnesium Technology 2016

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Iron–manganese: new class of metallic degradable biomaterials prepared by powder metallurgy

Cited by 250 publications

References 32 publications

Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents

Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents

Metals for Biomedical Applications

Absorbable Filament Technologies: Wire‐Drawing to Enable Next‐Generation Medical Devices

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