Iron Metabolism and Iron Deficiency in Infancy and Childhood

Smith, Nathan J.; Ríos, Ernesto

doi:10.1016/s0065-3101(22)00850-7

Cited by 33 publications

(4 citation statements)

References 56 publications

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“…To support blood volume expansion and somatic growth, iron is recycled from fetal Hb and is mobilized from stores, decreasing SF ( Table 2 ). Our estimates of infant body iron and compartmental iron are similar to previous estimates in infancy ( 39 , 40 ). Expert estimates of the mean or median requirement for absorbed iron (mg/day) at 6 to 7 months are as follows: 0.69 mg/day ( 15 ), 0.72 mg/day ( 41 ), and 0.79 mg/day ( 33 ).…”

Section: Discussionsupporting

confidence: 87%

Measurement of iron absorption and iron gains from birth to 6 months in breastfed and formula-fed infants using iron isotope dilution

Stoffel,

Cepeda-López,

Zeder

et al. 2024

Sci. Adv.

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Little is known about iron kinetics in early infancy. We administered stable iron isotopes to pregnant women and used maternal-fetal iron transfer to enrich newborn body iron. Dilution of enriched body iron by dietary iron with natural isotopic composition was used to assess iron kinetics from birth to 6 months. In breastfed (BF, n = 8), formula-fed (FF, n = 7), or mixed feeding (MF, n = 8) infants, median (interquartile range) iron intake was 0.27, 11.19 (10.46–15.55), and 4.13 (2.33–6.95) mg/day; iron absorbed was 0.128 (0.095–0.180), 0.457 (0.374–0.617), and 0.391 (0.283–0.473) mg/day (BF versus FF, P < 0.01); and total iron gains were 0.027 (−0.002–0.055), 0.349 (0.260–0.498), and 0.276 (0.175–0.368) mg/day (BF versus FF, P < 0.001; BF versus MF, P < 0.05). Isotope dilution can quantify long-term iron absorption and describe the trajectory of iron depletion during early infancy.

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Section: Discussionsupporting

confidence: 87%

Measurement of iron absorption and iron gains from birth to 6 months in breastfed and formula-fed infants using iron isotope dilution

Stoffel,

Cepeda-López,

Zeder

et al. 2024

Sci. Adv.

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“…One had marked anasarca, due to the severe hypoproteinemia), associated with diarrhea and dark stools. The other had an acute respiratory infection and, on normal testing, severe hypoproteinemia was also disclosed [1,5].…”

Section: Resultsmentioning

confidence: 99%

Gastric Tumors and Protein Losing Enteropathy

Martins

2023

J Chem Can Res

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2 patients presented with exudative gastropathy, anemia and severe hypoproteinemia. A 9 years old boy had hypertrophic glandular gastritis, involving almost all of the stomach and the other, a 4 month’s old boy, had an undifferentiated Teratoma at the level of the lesser curvature. Endoscopy was performed in both, leading to the definitive diagnoses in the 1st but not in the 2nd, in whom it could only be obtained in the operative specimen. The 1st had a total gastrectomy and the 2nd a partial gastrectomy, with lymph node dissection, associated with a pyloromyotomy and partial fundoplication. Both have remained cured and are living a normal life.

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“…The issue of iron homeostasis is particularly complicated in the preterm infant because of inadequate iron stores at birth, rapid rates of growth, and possibly incompletely developed controls of absorption and subsequent assimilation (10,11). Total transferrin and total iron-binding capacity are reduced in the presence of infection, hemolytic anemias, and hypoproteinemias (12). The relationship between those conditions and transferrin serum concentrations is poorly understood in premature infants.…”

Section: Biochemical Markers For the Assessment Of Protein-energy Mal...mentioning

confidence: 99%

Biochemical Markers for the Assessment of Protein—Energy Malnutrition

1989

J. pediatr. gastroenterol. nutr.

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Iron Metabolism and Iron Deficiency in Infancy and Childhood

Cited by 33 publications

References 56 publications

Measurement of iron absorption and iron gains from birth to 6 months in breastfed and formula-fed infants using iron isotope dilution

Measurement of iron absorption and iron gains from birth to 6 months in breastfed and formula-fed infants using iron isotope dilution

Gastric Tumors and Protein Losing Enteropathy

Biochemical Markers for the Assessment of Protein—Energy Malnutrition

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