2013
DOI: 10.3389/fcimb.2013.00050
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Iron metabolism and resistance to infection by invasive bacteria in the social amoeba Dictyostelium discoideum

Abstract: Dictyostelium cells are forest soil amoebae, which feed on bacteria and proliferate as solitary cells until bacteria are consumed. Starvation triggers a change in life style, forcing cells to gather into aggregates to form multicellular organisms capable of cell differentiation and morphogenesis. As a soil amoeba and a phagocyte that grazes on bacteria as the obligate source of food, Dictyostelium could be a natural host of pathogenic bacteria. Indeed, many pathogens that occasionally infect humans are hosted … Show more

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Cited by 25 publications
(32 citation statements)
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“…The roles of NRAMP proteins (NRAMP1 and NRAMP2) (a Natural Resistance‐Associated Membrane Protein) on ion homeostasis and resistance to bacterial infection have been well studied in Dictyostelium (Bozzaro et al ., ; Peracino et al ., ). In this study, we looked at the expression levels of NRAMP transporters previously characterized in D. discoideum and responsible for iron and manganese efflux from the phagosome (Peracino et al ., ).…”
Section: Discussionmentioning
confidence: 98%
“…The roles of NRAMP proteins (NRAMP1 and NRAMP2) (a Natural Resistance‐Associated Membrane Protein) on ion homeostasis and resistance to bacterial infection have been well studied in Dictyostelium (Bozzaro et al ., ; Peracino et al ., ). In this study, we looked at the expression levels of NRAMP transporters previously characterized in D. discoideum and responsible for iron and manganese efflux from the phagosome (Peracino et al ., ).…”
Section: Discussionmentioning
confidence: 98%
“…Pathogenic mycobacteria, such as M. marinum or M. tuberculosis , replicate in host cells in a distinct, membrane‐bound pathogen vacuole called MCV, followed by rupture of the vacuole membrane and exit of the bacteria to the cytoplasm (Cardenal‐Munoz et al, ; Koliwer‐Brandl et al, ; Russell, ). The MCV represents a metal ion‐poor environment (Chao et al, ), which is depleted of iron due to the activity of NRAMP‐1, a proton‐driven transporter of ferric iron (Bozzaro, Buracco, & Peracino, ; Buracco et al, ; Buracco, Peracino, Andreini, Bracco, & Bozzaro, ; Peracino, Buracco, & Bozzaro, ).…”
Section: Discussionmentioning
confidence: 99%
“…As an antibacterial strategy against vacuolar pathogens, micronutrient deple- tion by the chelator phytate might function in parallel with transporters that remove metal ions from the pathogen vacuole. Accordingly, the transmembrane proteins Nramp-1 and Nramp-2 have been shown to pump iron from vacuoles (LCVs) to the cytoplasm of D. discoideum (56,57). Whereas the eukaryotic cell limits the availability of micronutrients by producing chelators and ion pumps, the intracellular pathogen L. pneumophila developed means to counteract the bacteriostatic strategy.…”
Section: Discussionmentioning
confidence: 99%