Iron Metabolism and the Hypochromic Anemia of Infancy

Relative tibia long bone growth in the Libben and Bt‐5 prehistoric skeletal populations

“…Porotic hyperostosis refers to nonspecific cranial lesions induced by erythroid marrow hyperplasia in response to an underlying anemic stimulus (Angel, 1967;Moseley, 1974). In a previous study it was found that the age-specific distribution for subadult porotic hyperostosis strongly conformed to patterns of the hypochromic microcytic iron deficiency anemia of infants and children reported for modern groups (Josephs, 1953(Josephs, , 1956Mensforth et al, 1978 and references therein). Data comparing the frequencies and agespecific distributions for remodeled and un- probability).…”

The Influence of Maternal Iron-deficiency Anaemia on the Haemoglobin of the Infant

“…The view that the blood of the newborn baby is the major source of the iron to be used later in maintaining haemoglobin levels is well documented (Lintzel, Rechenberger and Schairer, 1944;Hemmeler, 1946;Neander and Vahlquist, 1949;Langley, 1951;McCance and Widdowson, 1951;Josephs, 1953). Smith et al (1955 also showed that transplacental Fes5 was 'diluted' by dietary iron when the infants were 3 to 4 months old.…”

Persistence and Utilization of Maternal Iron for Blood Formation During Infancy 12

“…Figure 1 shows the hemoglobin concentrations of the entire group of infants in comparison with controls from such clinics. 1 Some of these data were reported at the Annual Meeting, American Pediatric Society, French Lick, Indiana, May 6, 1950. The total activity of Fe' administered as tagged erythrocytes to each pregnant woman ranged from approximately 2 to 12 microcuries, equivalent to an initial dose rate of 0.1 to 1.0 millirad 3 per day in the mother's blood stream.…”

“…The decline results primarily from reduced hematopoiesis, though iron is present for the manufacture of hemoglobin and replacement of erythrocytes. The slow rise in hemoglobin concentration which occurs during the remainder of infancy may be affected by several factors, including the rapidity of body growth, the amount and absorption of dietary iron, and the amount and conservation of iron which was obtained transplacentally (1). An opportunity to measure the persistence and utilization of transplacental iron during infancy arose as a by-product of investigations of maternal red cell volume and hematocrit recently published from this hospital (2,3).…”