Iron metabolism and type 2 diabetes mellitus: A meta‐analysis and systematic review

Liu, Jingfang; Li, Qingxiu; Yang, Yongxiu; Ma, Lijun

doi:10.1111/jdi.13216

Cited by 95 publications

(89 citation statements)

References 39 publications

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“…Conversely, the hypothesized protective role of Zn has not been well demonstrated in human studies. Dietary intake [ 12 ] or supplementation [ 21 ] of Zn seemed to regress the progression of new-onset DM, whereas serum Zn had no association with DM in meta-analyses [ 9 , 10 , 11 ]. Besides, total zinc intake from both diet and supplementation failed to demonstrate the protective role toward diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…The association between Fe and DM is consistent. Elevated serum iron [ 34 ] and ferritin [ 9 ] as well as dietary Fe [ 16 ] were associated with an increased risk of DM. Additionally, excessive serum iron and ferritin were observed in the MetS group [ 15 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…A few observational studies were designed to clarify the associations between serum concentrations of Zn, Cu, or Fe and DM, but the results were inconsistent [ 6 , 7 , 8 ]. In recent meta-analyses, it seems that serum levels of Cu and Fe tend to be positively associated with the risk of DM, while the association between serum levels of Zn and DM was inconclusive [ 9 , 10 , 11 ]. Supported by a large population-based, five-year cohort study, dietary intake of Cu and Fe was associated with a higher risk of new-onset DM [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

Lee

Kuo

et al. 2021

Nutrients

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The association between serum concentrations of zinc, copper, or iron and the risk of metabolic syndrome are inconclusive. Therefore, we conduct a case-control study to explore the relationship between serum levels of zinc, copper, or iron and metabolic syndrome as well as each metabolic factor and insulin resistance. We enrolled 1165 adults, aged ≥ 40 (65.8 ± 10) years in a hospital-based population to compare the serum levels of zinc, copper, and iron between subjects with and without metabolic syndrome by using multivariate logistic regression analyses. The least square means were computed by general linear models to compare serum concentrations of zinc, copper, and iron in relation to the number of metabolic factors. The mean serum concentrations of zinc, copper, and iron were 941.91 ± 333.63 μg/L, 1043.45 ± 306.36 μg/L, and 1246.83 ± 538.13 μg/L, respectively. The odds ratios (ORs) of metabolic syndrome for the highest versus the lowest quartile were 5.83 (95% CI: 3.35–10.12; p for trend < 0.001) for zinc, 2.02 (95% CI: 1.25–3.25; p for trend: 0.013) for copper, and 2.11 (95% CI: 1.24–3.62; p for trend: 0.021) for iron after adjusting for age, sex, personal habits, body mass index, and homeostatic model assessment insulin resistance. Additionally, the serum zinc, copper, and iron concentrations increased as the number of metabolic factors rose (p for trend < 0.001). This was the first study to clearly demonstrate that higher serum levels of zinc, copper, and iron were associated with the risk of metabolic syndrome and the number of metabolic factors independent of BMI and insulin resistance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

Lee

Kuo

et al. 2021

Nutrients

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“…Beyond BCAA content, the source of dietary protein is thought to influence metabolic risk due to multiple other factors such as difference in iron and amino acid content [ 153 , 154 ]. Observational studies have shown an association between ferritin and T2DM suggesting a role of high iron stores in diabetes development [ 155 ]. However, this underlying association may be more complex than this simple link and has been reported to require further investigation [ 156 ].…”

Section: Dietary Management Of Diabetesmentioning

confidence: 99%

Dietary Management of Type 2 Diabetes in the MENA Region: A Review of the Evidence

2021

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The alarmingly rising trend of type 2 diabetes constitutes a major global public health challenge particularly in the Middle Eastern and North African (MENA) region where the prevalence is among the highest in the world with a projection to increase by 96% by 2045. The economic boom in the MENA region over the past decades has brought exceptionally rapid shifts in eating habits characterized by divergence from the traditional Mediterranean diet towards a more westernized unhealthy dietary pattern, thought to be leading to the dramatic rises in obesity and non-communicable diseases. Research efforts have brought a greater understanding of the different pathways through which diet and obesity may affect diabetes clinical outcomes, emphasizing the crucial role of dietary interventions and weight loss in the prevention and management of diabetes. The purpose of this review is to explore the mechanistic pathways linking obesity with diabetes and to summarize the most recent evidence on the association of the intake of different macronutrients and food groups with the risk of type 2 diabetes. We also summarize the most recent evidence on the effectiveness of different macronutrient manipulations in the prevention and management of diabetes while highlighting the possible underlying mechanisms of action and latest evidence-based recommendations. We finally discuss the need to adequately integrate dietetic services in diabetes care specific to the MENA region and conclude with recommendations to improve dietetic care for diabetes in the region.

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“…Ultimately affecting insulin production and increasing the risk to insulin resistance. Moreover, weakening of the ability of the liver to use insulin and gluconeogenesis [8] .…”

Section: Ironmentioning

confidence: 99%

Trace Elements and Their Relation to Diabetes Mellitus and Obesity .

Hassanin

Elkishki

Fawzy

2020

Journal of Recent Advances in Medicine

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Background: The human body is composed of two types of elements, abundant and trace elements. Abundant elements include the major elements that are important constituents of tissues e.g. oxygen, carbon, nitrogen, and hydrogen. Trace elements are micronutrients which are important for the human body, but they are only present in traceable quantities. They are classified into essential, and non-essential elements. Essential trace elements include iron, zinc, copper, cobalt, fluoride, iodide, manganese, molybdenum & selenium. Probably essential trace elements include Nickel, tin, vanadium, silicon, Boron. Non-essential trace elements include aluminum, lead, silver, mercury, rubidium, strontium, titanium, and zirconium. Although trace elements account for only 0.02% of the total body weight, yet they have many functions in the biological process. Some of them like iron, zinc, chromium, copper and iodine act as antioxidants and cofactors for many enzymes affecting the metabolism and insulin action and have great effect on insulin and leptin receptors. Nevertheless, the biochemical functions are well-defined. If the level of these micronutrients decreased or increased, widespread issues in human health occur. Aim: Some of the trace elements and their role in the pathology and development of obesity and diabetes mellitus are the subject of this article. Conclusion: This review concludes that deficiency or excess of some trace elements may contribute directly or indirectly to pathogenesis of diabetes mellitus and obesity. Further investigations are needed to complete gaps in our knowledge on trace elements.

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Iron metabolism and type 2 diabetes mellitus: A meta‐analysis and systematic review

Cited by 95 publications

References 39 publications

Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

Dietary Management of Type 2 Diabetes in the MENA Region: A Review of the Evidence

Trace Elements and Their Relation to Diabetes Mellitus and Obesity .

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