Iron Metabolism, Iron Deficiency and Disorders of Haem Synthesis

Camaschella, Clara; Av, Hoffbrand; Hershko, Chaim

doi:10.1002/9781118853771.ch3

Cited by 14 publications

(15 citation statements)

References 11 publications

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“…The last measure has been shown in controlled clinical trials to protect frequent blood donors from iron depletion with the result that both anemia and nonanemic consequences of iron depletion are prevented . Iron depletion has also been reported in apheresis donors, particularly platelet apheresis donors . In the face of increasing attention to this problem by community blood centers and regulatory authorities, we believe our data are important and provide evidence that no further action by SP donor centers is needed to ensure adequate iron stores.…”

Section: Discussionmentioning

confidence: 99%

Frequent source plasma donors are not at risk of iron depletion: the Ferritin Levels in Plasma Donor (FLIPD) study

Schreiber¹,

Brinser²,

Rosa-Bray

et al. 2018

Transfusion

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Section: Discussionmentioning

confidence: 99%

Frequent source plasma donors are not at risk of iron depletion: the Ferritin Levels in Plasma Donor (FLIPD) study

Schreiber¹,

Brinser²,

Rosa-Bray

et al. 2018

Transfusion

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“…As iron levels decline in the stores (iron deficiency) and in the circulation (iron restricted erythropoiesis) becoming insufficient for the full hemoglobinization of mature erythroblasts (iron deficiency anemia), the liver peptide hormone hepcidin is transcriptionally suppressed. 4 Indeed serum hepcidin levels are significantly lower in young women with a negative iron balance compared with males and postmenopausal women, and are even undetectable in serum of individuals with iron deficiency anemia. 5,6 The decrease of hepcidin enhances iron release into plasma through ferroportin from both enterocytes and macrophages in the attempt of maintaining normal transferrin.…”

Section: Mechanism Of Adaptation To Iron Deficiencymentioning

confidence: 99%

“…Once the gold standard for the diagnosis of iron deficiency, Perl's staining is rarely assessed because it is qualitative and requires performance of an invasive procedure. 4 In general the combination of tests rather than a single test helps to ascertain the correct diagnosis (Table 2).…”

Section: Laboratory Diagnosis Of Iron Deficiency and Iron Deficiency mentioning

confidence: 99%

“…At this point serum ferritin is usually Ͻ12 ng/mL. 4 In parallel, soluble transferrin receptor is shed in the circulation by the proprotein convertase subtilisin/kexin 7 (PCSK7), which cleaves the receptor when unbound to its ligand. 27 Both transferrin saturation and serum ferritin are consensually decreased in iron deficiency anemia.…”

Section: Laboratory Diagnosis Of Iron Deficiency and Iron Deficiency mentioning

confidence: 99%

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Iron deficiency: new insights into diagnosis and treatment

2015

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Iron deficiency and iron deficiency anemia are common conditions worldwide affecting especially children and young women. In developing countries, iron deficiency is caused by poor iron intake and/or parasitic infection, whereas vegetarian dietary choices, poor iron absorption, and chronic blood loss are common causes in high-income countries. Erythropoiesis stimulating agents can result in functional iron deficiency for erythropoiesis even when stores are iron-replete. Diagnosis of iron deficiency is straightforward, except when it occurs in the context of inflammatory disorders. Oral iron salts correct absolute iron deficiency in most patients, because low hepcidin levels facilitate iron absorption. Unfortunately frequent side effects limit oral iron efficacy. Intravenous iron is increasingly utilized, because currently available preparations allow rapid normalization of total body iron even with a single infusion and are effective also in functional iron deficiency and in iron deficiency associated with inflammatory disorders. The evidence is accumulating that these preparations are safe and effective. However, long-term safety issues of high doses of iron need to be further explored. Learning Objectives• To diagnose absolute iron deficiency, iron deficiency anemia, and functional iron deficiency in the light of recent advances in iron metabolism • To evaluate advantages and disadvantages of oral and intravenous iron therapy

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“…5 The amount of iron in the adult human body is normally about 50 mg/kg in males and 40 mg/kg in females. 6 Iron deficiency anaemia is a worldwide health problem and is the most common form of nutritional deficiency.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of efficacy of intravenous iron sucrose versus ferric carboxymaltose in the treatment of iron deficiency anaemia

Mahfuz¹,

Hossain²,

Uddin³

et al. 2020

Haematol J Bangladesh

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Background: Iron deficiency anaemia (IDA) is a common haematological complication with potentially serious clinical consequences that may require intravenous iron therapy. Parenteral iron therapy results faster and higher replenishment of iron stores and correction of Haemoglobin (Hb) levels with better compliance. The study was to compare the efficacy of intravenous ferric carboxymaltose with intravenous iron sucrose to treat iron deficiency anaemia. Methods: 188 patients were included in the study. 100 patients were given iron sucrose. After a 25 mg test dose on the first infusion only, this was given at a dose of 300 mg by intravenous infusion diluted in 100 ml of normal saline, every alternate day. 88 patients were treated with ferric carboxymaltose at a dose of 500 mg diluted in 100 ml of normal saline by intravenous infusion. Hb level and serum Ferritin of both groups were done before iron therapy and 3 weeks after iron therapy. Results: The mean±SD rise of haemoglobin concentration 3 weeks after iron therapy in iron sucrose group was 11.0±0.61 g/dL, while in ferric carboxymaltose group was 11.2±0.64 g/dL. The mean±SD ferritin 3 weeks after iron therapy in iron sucrose group was 76.0±14.28 ng/mL, while in ferric carboxymaltose group was 80.0±15.16 ng/mL. No serious adverse events were reported in either the ferric carboxymaltose group or iron sucrose group. Conclusions: Ferric carboxymaltose causes higher rise in Hb level as compared to parenteral iron sucrose.

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Iron Metabolism, Iron Deficiency and Disorders of Haem Synthesis

Cited by 14 publications

References 11 publications

Frequent source plasma donors are not at risk of iron depletion: the Ferritin Levels in Plasma Donor (FLIPD) study

Frequent source plasma donors are not at risk of iron depletion: the Ferritin Levels in Plasma Donor (FLIPD) study

Iron deficiency: new insights into diagnosis and treatment

Comparative study of efficacy of intravenous iron sucrose versus ferric carboxymaltose in the treatment of iron deficiency anaemia

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