2022
DOI: 10.3389/fphar.2022.1040845
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Iron metabolism-related genes reveal predictive value of acute coronary syndrome

Abstract: Iron deficiency has detrimental effects in patients with acute coronary syndrome (ACS), which is a common nutritional disorder and inflammation-related disease affects up to one-third people worldwide. However, the specific role of iron metabolism in ACS progression is opaque. In this study, we construct an iron metabolism-related genes (IMRGs) based molecular signature of ACS and to identify novel iron metabolism gene markers for early stage of ACS. The IMRGs were mainly collected from Molecular Signatures Da… Show more

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Cited by 4 publications
(1 citation statement)
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“…In conclusion, we developed a five-gene pair signature using the iPAGE method to predict the prognosis of glioma patients and assist clinical management. Our approach, which utilizes the relative expression of gene pairs, offers a significant advancement over models based on individual genes, enabling data integration and batch-effect mitigation [ 73–75 ]. MrGPS is associated with immune infiltration, immune checkpoints and response of ICI therapy, suggesting that these factors may play crucial roles in influencing the prognosis of glioma.…”
Section: Discussionmentioning
confidence: 99%
“…In conclusion, we developed a five-gene pair signature using the iPAGE method to predict the prognosis of glioma patients and assist clinical management. Our approach, which utilizes the relative expression of gene pairs, offers a significant advancement over models based on individual genes, enabling data integration and batch-effect mitigation [ 73–75 ]. MrGPS is associated with immune infiltration, immune checkpoints and response of ICI therapy, suggesting that these factors may play crucial roles in influencing the prognosis of glioma.…”
Section: Discussionmentioning
confidence: 99%