Iron metabolism: State of the art in hypoxic cancer cell biology

Liu, Sai; Cao, Xiongfeng; Wang, Dongqing; Zhu, Haitao

doi:10.1016/j.abb.2022.109199

Cited by 17 publications

(12 citation statements)

References 172 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the hypoxic TME, tumor evasion could promote ferroptosis resistance, reduce phagocytosis, and affect immunogenic ferroptosis. Liu et al found that Fe 2+ from hypoxic cancer cells, by metabolic coupling with the labile iron pool (LIP), coregulates mitochondrial iron homeostasis in cancer cells to promote invasion [ 10 ]. Besides, TME also intervenes in cancer patients' survival through tumor-infiltrating immune cells (TIICs).…”

Section: Introductionmentioning

confidence: 99%

Identification of Ferroptosis-Associated Long Noncoding RNA Prognostic Model and Tumor Immune Microenvironment in Thyroid Cancer

Lin

Gan

He³

et al. 2022

Journal of Immunology Research

View full text Add to dashboard Cite

Background. Thyroid cancer (TC) is a rapidly increasing incidence of endocrine malignancies, occupying 3% of new cancer incidence, of which 10% has a heterogeneous prognosis. Ferroptosis is a form of cell death distinct from apoptosis, which involves antitumor drug-related research. Long noncoding RNAs (lncRNAs) could affect cancer prognosis by regulating the ferroptosis; thus, ferroptosis-associated lncRNAs are emerging as prospective biomarkers for cancer therapy and prognosis. However, the prognostic factors of ferroptosis-associated lncRNAs in this solid tumor and their mechanisms remain unknown. Methods. The TC lncRNA data were extracted from RNA sequencing files of The Cancer Genome Atlas (TCGA). Then, we performed a two-cluster analysis and grouped 502 patients with TC in a 7 : 3 ratio. Both the least absolute shrinkage and selection operator (LASSO) regression and Cox regression analysis were conducted to create and validate the ferroptosis-associated lncRNA prognostic model (Ferr-LPM). Based on the median Ferr-LPM-based risk score (LPM_score) of the training cohort, we categorized patients into high and low LPM_score groups, which were then subjected to prognostic correlation and difference analysis. We also created a nomogram and assessed its predictive ability. Furthermore, immune-related mechanisms were investigated by analyzing the tumor immune microenvironment (TIME) and applying algorithms such as CIBERSROT. Results. We built a highly accurate nomogram to promote the clinical applicability of Ferr-LPM. The area under the receiver operating characteristic curve (AUC-ROC) reached above 0.9. Survival analysis suggested that when the Ferr-LPM score was higher, the overall survival (OS) of patients within this group was shorter. Meanwhile, we found a strong association between Ferr-LPM and TIME. Interestingly, the LPM_score was inversely proportional to the tumor purity but positively related to immune checkpoint blockade (ICB) response. Conclusion. We constructed a novel ferroptosis-associated lncRNA nomogram that could highly predict the prognosis of TC patients. Ferroptosis-associated lncRNAs might possess potential functions in regulating TIME, and lncRNAs provide TC patients with new prognostic biomarkers and therapeutic targets.

show abstract

Section: Introductionmentioning

confidence: 99%

Identification of Ferroptosis-Associated Long Noncoding RNA Prognostic Model and Tumor Immune Microenvironment in Thyroid Cancer

Lin

Gan

He³

et al. 2022

Journal of Immunology Research

View full text Add to dashboard Cite

show abstract

“…Thus, the use of ARBs by smokers may increase the risk of lung diseases resulting from an abnormally high Fe concentration. Notably, Fe homeostasis is disturbed in cancer cells, which show a heightened demand for this transition metal [ 46 , 47 ], and Fe dysregulation is associated with lung cancer initiation and development [ 48 ]. Our results suggest that ARBs may increase the risk of cancer in hypertensive patients who smoke.…”

Section: Resultsmentioning

confidence: 99%

Concentrations of Transition Metal Ions in Rat Lungs after Tobacco Smoke Exposure and Treatment with His-Leu Dipeptide

et al. 2023

View full text Add to dashboard Cite

Tobacco smoking is deleterious to the lungs because it exposes them to many toxic substances. These include transition metal ions, such as cadmium. However, there is a lack of information about the influence of endogenous metal-binding peptides, such as His-Leu (HL), on the lung distribution of transition metals in smokers. To address this, we administered HL subcutaneously to rats exposed to tobacco smoke for six weeks, then we measured the concentrations of transition metal ions in the lungs. We found that exposure to tobacco smoke elevates the concentrations of Cd(II) and Cu(II). Administration of the HL peptide, whose elevation is a consequence of angiotensin receptor blocker anti-hypertension therapy, increases the concentration of Fe in the lungs of rats exposed to smoke. These findings suggest that smoking is a risk factor for patients receiving angiotensin receptor blockers to treat hypertension.

show abstract

“…Iron increases the risk of tumor development through mechanisms such as inducing oxidative damage, promoting the production of inflammatory factors, and reducing tumor surveillance by the immune system, and iron can also alter normal signal transduction pathways to promote tumor proliferation and metastasis (32,33). In recent years, many proteins involved in iron metabolism have been discovered (34), and targeting iron therapy may be a new strategy for tumor treatment (35). This indicates that elevated serum iron is a positive factor in tumor development.…”

Section: Discussionmentioning

confidence: 99%

Serum zinc in patients with colorectal cancer might contribute to the prediction of tumor clinical staging scores： a prospective single-center clinical study

Zhang

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Diagnosis for colorectal cancer is infrequently diagnosed and not accurate staging. Trace elements may be involved in the whole process of intestinal tumors. Can trace elements be used to predict condition and staging scores for colorectal cancer? Methods: Patients(n=74) and the control group (n=32) were enrolled. Data from the first acceptance were recorded including age, gender, clinical staging scores of tumors, and tumor biomarkers. The serological specimens were tested for magnesium, iron, copper, zinc, calcium, and selenium with ICP-MS. T-test was used to analyze serum trace elements in patients and the control group, and LASSO regression was executed to screen which factors contributed most to clinical staging scores. Results: The level of copper in the control group is lower than in the patients (p=0.0004, ∆mean±SEM=210.7±57.79, and 95%CI=96.14to325.4). For the other five trace elements in the control group is higher than in the patients, respectively manganese (p=0.0003, ∆ mean±SEM=-1.658±0.4470, 95%CI=-2.544to-0.7713), iron (p=0.0343, ∆ mean=-0.3672±0.1712, 95%CI=-0.7068to-0.02761), zinc (p=0.0059, ∆ mean=-0.1348±0.04794, 95%CI=-0.2298to-0.03968), calcium (p<0.0001, ∆ mean=-15.10±3.482, 95%CI=-22.00to-8.195), selenium (p=0.0216, ∆mean=-12.23±5.242, 95%CI=-22.62to-1.832). The results of LASSO regression show variables selected are Ca125 （ coefficient=5.8e-04 ） , Ca199 （coefficient=7.4e-05）, zinc（coefficient=-0.2047）， and intercept（3.1951）, which are regarded as the most contributing to the clinical staging scores， the coefficients for other factors are zero. Conclusions: Ca125 and Ca199 are positively contributing to the clinical staging scores, and zinc is negatively correlated with them. Therefore, we suggest that serum zinc might be used to predict the clinical staging scores of patients with colorectal cancer.

show abstract

Iron metabolism: State of the art in hypoxic cancer cell biology

Cited by 17 publications

References 172 publications

Identification of Ferroptosis-Associated Long Noncoding RNA Prognostic Model and Tumor Immune Microenvironment in Thyroid Cancer

Identification of Ferroptosis-Associated Long Noncoding RNA Prognostic Model and Tumor Immune Microenvironment in Thyroid Cancer

Concentrations of Transition Metal Ions in Rat Lungs after Tobacco Smoke Exposure and Treatment with His-Leu Dipeptide

Serum zinc in patients with colorectal cancer might contribute to the prediction of tumor clinical staging scores： a prospective single-center clinical study

Contact Info

Product

Resources

About