Iron nanoparticles as novel vaccine adjuvants

Behzadi, Maryam; Vakili, Bahareh; Ebrahiminezhad, Alireza; Nezafat, Navid

doi:10.1016/j.ejps.2021.105718

Cited by 30 publications

(15 citation statements)

References 137 publications

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“…Therefore, inorganic adjuvants have broad application prospects. Common inorganic adjuvants include aluminum salt adjuvants, silicon‐based adjuvants, metal adjuvants such as gold, and metal oxides such as manganese, [ 62 ] cobalt, [ 63 ] and iron oxides, [ 64 ] as well as calcium phosphate, [ 65 ] quantum dots, [ 66 ] and hydroxyapatite. [ 67 ] Here, we will introduce several common inorganic adjuvants.…”

Section: The Types Of Adjuvantsmentioning

confidence: 99%

“…[133,134b] Nanoadjuvants systems can deliver therapeutic agents and treat areas of the body that cannot be reached by other delivery systems. [ 134a,137 ] There are many nanoadjuvants that have a good effect on cancer treatments, [ 138 ] such as polymer nanoadjuvants, and aluminum nanoadjuvants, [ 13,70 ] manganese oxide nanoadjuvants, [ 62 ] iron oxide nanoadjuvants [ 64,139 ] and other metal nanoadjuvants. [ 137 ] As well as some nano‐scale viral vectors, virus‐like particles, irosomes and‐viral vectors, etc.…”

Section: Structure–function Relationships Of Nanoadjuvantsmentioning

confidence: 99%

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Understanding Structure–Function Relationships of Nanoadjuvants for Enhanced Cancer Vaccine Efficacy

Tan

Ding

Teng

et al. 2022

Adv Funct Materials

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Adjuvant, as an important part of vaccines, can observably enhance the magnitude, breadth and durability of immune responses. Nanoadjuvants, as novel vaccine adjuvants, have shown unique advantages and broad application prospects. This review focuses on nanoadjuvants and their structurefunction relationships as well as cancer therapy applications. First, different kinds of adjuvants are first introduced and organic/inorganic adjuvants are emphatically listed. Second, the mechanisms of adjuvants are expounded, covering reservoir effect, stimulating dendritic cells (DCs) maturity, enhancing antigen uptake/cross-presentation, activating complement and inducing cytokines/chemokines release. Next, the methods to evaluate immune effects of adjuvants, including expressions of antigen presenting/costimulatory molecules, detections of T lymphocytes subtypes, antigen-specific antibodies and cytokine secretion, are summarized. Then the authors emphatically focus on the structure-function relationships of nanoadjuvants, exploring the influence of the size, surface charge, surface ligand, aperture, morphology, and aspect ratio on the immune activities. Finally, the authors briefly discuss the safety of adjuvants and present some representative advances of nanoadjuvants in tumor immunotherapy, photothermal immunotherapy, photodynamic immunotherapy, sonodynamic immunotherapy, chemotherapy or radiotherapy/immunotherapy, chemodynamic immunotherapy and multiple therapies. They hope this review can provide comprehensive understanding and broaden the scopes of nanoadjuvants, thus pave the way to the translation from bench to bedside in the future.

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Section: The Types Of Adjuvantsmentioning

confidence: 99%

Section: Structure–function Relationships Of Nanoadjuvantsmentioning

confidence: 99%

Understanding Structure–Function Relationships of Nanoadjuvants for Enhanced Cancer Vaccine Efficacy

Tan

Ding

Teng

et al. 2022

Adv Funct Materials

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“…Metallic nanoparticles (MeNPs) have aroused particular interest as adjuvant agents due to their capacity for cell recruitment, ability to increase cytokine production, and induce a humoral immune response [ 63 , 64 , 65 , 66 , 67 ]. Low toxicity, chemical inertness, biocompatibility, and biodistribution properties have made metallic nanoparticles, in particular gold nanoparticles (AuNPs), excellent candidates for the development of nanovaccines during last years.…”

Section: Metal Complexes In Antiviral Vaccinesmentioning

confidence: 99%

Metal-Based Compounds in Antiviral Therapy

et al. 2022

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In recent years, the study of metal complexes and metal-based nanomaterials has aroused particular interest, leading to the promotion of new effective systems for the abatement of various viral diseases. Starting from the analysis of chemical properties, this review focuses on the employment of metal-based nanoparticles as antiviral drugs and how this interaction leads to a substantial enhancement in antiviral activity. The use of metal-based antiviral drugs has also spread for the formulation of antiviral vaccines, thanks especially to the remarkable adjuvant activities of some of the metal complexes. In particular, the small size and inert nature of Au- and Ag-based nanoparticles have been exploited for the design of systems for antiviral drug delivery, leading to the development of specific and safe therapies that lead to a decrease in side effects.

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“…Застосування наночастинок металів у біотехнології виготовлення вакцин можливо здійснювати у двох напрямахяк окремого складового компонента вакцинного препарату або як каталізаторів метаболічних процесів у клітинах виробничих штамів збудників для одержання великих об'ємів бактеріальної маси за їхнього використання на певному етапі технологічного процесу [7,8]. Тому, вивчення особливостей впливу наночастинок металів на модуляцію біохімічних процесів у клітинах патогенних культур є актуальним питанням, оскільки відкриває перспективи щодо контролювання і регулювання інтенсивності їхніх фізіолого-біохімічних реакцій та дає можливість удосконалювати біотехнологію виготовлення вакцинних препаратів.…”

Section: вплив наночастинок заліза (Fenp) в складі поживного середовища для аеробів на ріст і розмноження Escherichia соLіunclassified

Role of the iron nanoparticles (FeNP) in the culture medium for anaerobic microorganisms on growth and reproduction of Escherichia cоlі

Zhovnyr¹,

Andryiashchuk²,

Mintsiuk³

et al. 2021

Veterinary biotechnology

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Iron nanoparticles as novel vaccine adjuvants

Cited by 30 publications

References 137 publications

Understanding Structure–Function Relationships of Nanoadjuvants for Enhanced Cancer Vaccine Efficacy

Understanding Structure–Function Relationships of Nanoadjuvants for Enhanced Cancer Vaccine Efficacy

Metal-Based Compounds in Antiviral Therapy

Role of the iron nanoparticles (FeNP) in the culture medium for anaerobic microorganisms on growth and reproduction of Escherichia cоlі

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