Iron Overload and Mobilization in Long-Term Hemodialysis Patients

Hakim, Raymond M.; Stivelman, John C.; Schulman, Gerald; Fosburg, M; Wolfe, Lawrence C.; Imber, Michael J.; Lazarus, J. Michael

doi:10.1016/s0272-6386(87)80025-2

Cited by 50 publications

(16 citation statements)

References 24 publications

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“…Further, repeated transfusions can lead to iron overload (in extreme cases hemosiderosis), which was a challenging clinical problem in the ESRD population before the approval of epoetin alfa in 1989. 21 In addition, exposure to blood transfusion markedly increases the likelihood of allosensitization in patients eligible for kidney transplantation. 22 In addition to increasing the odds of a positive crossmatch, disqualifying potential donors, 23 allosensitization is associated with accelerated graft loss, even among patients lucky enough to crossmatch negative and receive a kidney.…”

Section: Discussionmentioning

confidence: 99%

Trends in Anemia Care in Older Patients Approaching End-Stage Renal Disease in the United States (1995-2010)

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Trends in Anemia Care in Older Patients Approaching End-Stage Renal Disease in the United States (1995-2010)

et al. 2014

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“…Only one study has found a negative association between serum ferritin levels and haemoglobin levels in a large cohort of renal transplant recipients [10]. Hyperferritinaemia with ferritin levels > 1000 ng mL −1 was detected in 4·6% of patients, and was most likely the result of transfusion‐related iron overload [38,41] or liver disease [38]. Hyperferritinaemia may have prognostic importance in kidney graft recipients.…”

Section: Iron Deficiency After Renal Transplantationmentioning

confidence: 99%

Anaemia after renal transplantation

Lorenz

Winkelmayer

Hörl

et al. 2005

Eur J Clin Investigation

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Anaemia is a frequent complication among long-term renal transplant recipients. A prevalence of approximately 40% has been reported in several studies. If renal function declines to stage 5 kidney disease, the prevalence of anaemia in kidney transplants is even higher. A positive correlation between haemoglobin concentration and creatinine clearance has been reported, which is a function of endogenous erythropoietin production by the functioning graft. Inflammation related to a retained kidney graft may cause hypo-responsiveness to erythropoietic agents once kidney transplant recipients return to dialysis. Furthermore, the use of azathioprine, mycophenolate mofetil and sirolimus may be associated with post-transplant anaemia. Along with erythropoietin deficiency, depletion of iron stores is one of the major reasons for anaemia in the kidney transplant population. The proportion of hypochromic red blood cells appears to be a useful parameter to measure iron supply and utilization as well as to estimate mortality risks in kidney transplant recipients. While anaemia is an important cardiovascular risk-factor after transplantation, our data suggest that anaemia is not associated with mortality and graft loss. Nevertheless, inadequate attention is paid so far to the management of anaemia after renal transplantation. A promising future aspect for risk reduction of cardiovascular disease includes the effect of erythropoietic agents on endothelial progenitor cells.

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“…In thalassaemia there is a marked tendency for an increase in the saturation of the serum transferrin (29), while chronic haemodialysis patients frequently suffer from severe iron overload with ferritin levels exceeding 2000 ng/ml (normal 10-360 ng/ml) (42).…”

Section: Yersinia Enterocohtica: the Role Of Iron In Septicaemiamentioning

confidence: 99%

The critical role of iron in some clinical infections

Bullen

Ward

Rogers³

1991

Eur. J. Clin. Microbiol. Infect. Dis.

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The role of iron in certain clinical infections is revealed. In normal persons the antibacterial and antifungal properties of blood and other tissue fluids cannot be maintained unless there are exceptionally low levels of available iron. This is controlled by the presence of the unsaturated iron-binding proteins, transferrin and lactoferrin. In several clinical conditions an abnormal availability of iron is responsible for fatal septicaemia. This is because the phagocytic system is overwhelmed by rapidly growing organisms when iron is freely available.

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Iron Overload and Mobilization in Long-Term Hemodialysis Patients

Cited by 50 publications

References 24 publications

Trends in Anemia Care in Older Patients Approaching End-Stage Renal Disease in the United States (1995-2010)

Trends in Anemia Care in Older Patients Approaching End-Stage Renal Disease in the United States (1995-2010)

Anaemia after renal transplantation

The critical role of iron in some clinical infections

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