Iron overload and non-alcoholic fatty liver disease

Datz, Christian; Müller, Elena; Aigner, Elmar

doi:10.23736/s0391-1977.16.02565-7

Cited by 88 publications

(46 citation statements)

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“…( 4 ) NAFLD, with high serum ferritin and normal hepatic iron concentrations, is a condition known as metabolic hyperferritinemia, which is associated with increased risk of liver fibrosis. ( 21 , 22 )…”

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confidence: 99%

MRI‐Based Iron Phenotyping and Patient Selection for Next‐Generation Sequencing of Non–Homeostatic Iron Regulator Hemochromatosis Genes

et al. 2021

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confidence: 99%

MRI‐Based Iron Phenotyping and Patient Selection for Next‐Generation Sequencing of Non–Homeostatic Iron Regulator Hemochromatosis Genes

et al. 2021

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“…Bilateral substantia nigra in patients with Parkinson's disease exhibit increased iron levels ( 8 ). Non-alcoholic fatty liver disease, which shows signs of elevated serum ferritin concentration, has been confirmed to be closely related to type 2 diabetes ( 2 , 9 , 10 ). Therefore, both iron deficiency and iron overload are harmful to human health, and it is essential to maintain iron homeostasis in the body.…”

Section: Introductionmentioning

confidence: 95%

“…Iron, the most abundant trace element in the human body, is involved in various biological processes such as oxygen transport, mitochondrial respiration and DNA synthesis ( 1 , 2 ). Iron deficiency causes numerous types of diseases.…”

Section: Introductionmentioning

confidence: 99%

Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma

et al. 2021

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Melanoma, the most aggressive skin cancer, is mainly treated with BRAF inhibitors or immunotheareapy. However, most patients who initially responded to BRAF inhibitors or immunotheareapy become resistant following relapse. Ferroptosis is a form of regulated cell death characterized by its dependence on iron ions and the accumulation of lipid reactive oxygen species (ROS). Recent studies have demonstrated that ferroptosis is a good method for tumor treatment, and iron homeostasis is closely associated with ferroptosis. Iron regulatory protein (IRP)1 and 2 play important roles in maintaining iron homeostasis, but their functions in ferroptosis have not been investigated. The present study reported that the expression of IRP1 and IRP2 was increased by the ferroptosis inducers erastin and RSL3 in melanoma cells. Depletion of IRP1 significantly suppressed erastin-and RSL3-induced ferroptosis. IRP2 had a weak effect but could enhance the promoting function of IRP1 on ferroptosis. Further, erastin and RSL3 promoted the transition of aconitase 1 to IRP1, which regulated downstream iron metabolism proteins, including transferrin receptor (TFRC), ferroportin (FPN) and ferritin heavy chain 1 (FTH1). Moreover, overexpression of TFRC and knockdown of FPN and FTH1 significantly promoted erastin-and RSL3-induced ferroptosis in IRP1 knockdown melanoma cells. Collectively, the present findings indicate that IRP1 plays an essential role in erastinand RSL3-induced ferroptosis by regulating iron homeostasis.

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“…These patients often have elevated serum ferritin levels with either normal or mild elevation in TF saturation levels, and additionally, upon liver biopsy, they often have a hepatic iron disposition. The term "dysmetabolic iron overload syndrome (DIOS)" has is used to describe these findings (45).…”

Section: Nonalcoholic Fatty Liver Disease (Nafld) Related To Iron Overloadmentioning

confidence: 99%

The Role of the Liver in Iron Homeostasis and What Goes Wrong?

Gonzaga¹,

Guiance²,

Henriquez³

et al. 2021

jrenhep

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Iron is an essential mineral that is vital for growth development, normal cellular function, synthesis of hormones and connective tissue, and most importantly, serves as a component of hemoglobin to carry oxygen to body tissues. The body finely regulates the amount of circulating and stored iron within the body to maintain concentration levels within range for optimal physiologic function. Without iron, the ability for cells to participate in electron transport and energy metabolism decreases. Furthermore, hemoglobin synthesis is altered, which leads to anemia and decreased oxygen delivery to tissue. Problems arise when there is too little or too much iron. This review explores the role of the liver in iron physiology, iron overload and discusses the most common causes of primary and secondary hepatic iron overload.

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Iron overload and non-alcoholic fatty liver disease

Cited by 88 publications

References 0 publications

MRI‐Based Iron Phenotyping and Patient Selection for Next‐Generation Sequencing of Non–Homeostatic Iron Regulator Hemochromatosis Genes

MRI‐Based Iron Phenotyping and Patient Selection for Next‐Generation Sequencing of Non–Homeostatic Iron Regulator Hemochromatosis Genes

Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma

The Role of the Liver in Iron Homeostasis and What Goes Wrong?

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