Iron overload in the liver diagnostic and quantification

Alústiza, J.M.; Castiella, Agustín; Juan, Montse; Emparanza, José Ignacio; Artetxe, Jose; Uranga, M.

doi:10.1016/j.ejrad.2006.11.012

Cited by 64 publications

(82 citation statements)

References 30 publications

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“…MRI is now the preferred technique for estimating and monitoring iron stores in patients without kidney disease because of its reproducibility, sensitivity, availability and ability to scan multiple organs in the same session [51,52]. There are three MRI modalities for liver iron assay: the signal-intensity ratio, R2 relaxometry, and R2* relaxometry [53][54][55] (see the article by Professor Gandon et al).…”

Section: Noninvasive Imaging Of Liver Iron Stores By Mri: Specific Fementioning

confidence: 99%

Iatrogenic iron overload and its potential consequences in patients on hemodialysis

Rostoker

Vaziri

2017

La Presse Médicale

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Section: Noninvasive Imaging Of Liver Iron Stores By Mri: Specific Fementioning

confidence: 99%

Iatrogenic iron overload and its potential consequences in patients on hemodialysis

Rostoker

Vaziri

2017

La Presse Médicale

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“…Histological evaluation performed by a trained pathologist, after Perls staining, may also be useful to quantify iron overload, especially during genetic hemochromatosis (4). Several groups have reported noninvasive quantification of hepatic iron overload using MRI methods (5). Most studies were done on humans (6)(7)(8)(9)(10)(11), only a few having been performed on rodents (12)(13)(14)(15).…”

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confidence: 99%

MRI quantification of splenic iron concentration in mouse

Hitti

Éliat

Abgueguen

et al. 2010

Magnetic Resonance Imaging

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Purpose: To quantify hepatic and splenic iron load, which is a critical issue for iron overload disease diagnosis. MRI is useful to noninvasively determine liver iron concentration, but not proven to be adequate for robust evaluation of splenic iron load. We evaluated the usefulness of MRI-derived parameters to determine splenic iron concentration in mice. Materials and Methods:A mouse model of experimental iron load was used. Multi-echo spin-echo images of liver and spleen were acquired at 4.7 Tesla. The parameters were tested at all echoes with and without an external reference. Splenic and hepatic iron concentrations were determined using biochemical assay as the gold standard.Results: Our results show that (i) use of an internal or external reference is essential; (ii) optimal echo times were TE ¼ 19.5 ms and TE ¼ 32.5 ms for the liver and spleen, respectively; (iii) in the liver, the relationship between biochemical and MRI iron concentration determinations is logarithmic; (iv) in the spleen, the best relationship is an inverse function. Conclusion:A single spin-echo sequence allows robust estimation of hepatic and splenic iron content. Parameters classically used for hepatic iron concentration cannot be applied to splenic iron determination, which requires both the specific sequence and the adapted fitting function.

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“…Liver iron concentration correlates closely with the total body iron stores [5]. The excess iron accumulates mainly in the liver and the progressive accumulation of toxic iron can lead to organ failure if untreated [2,4]. Several diseases causing iron overload, such as transfusiondependent anaemia, haematological malignancies, thalassaemia, haemochromatosis and chronic liver disease, result in a large number of patients with a potentially treatable iron overload [1,2,4].…”

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confidence: 99%

“…Iron overload is a clinically recognised condition with variety of aetiologies and clinical manifestations [1][2][3][4]. Liver iron concentration correlates closely with the total body iron stores [5].…”

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confidence: 99%

“…Several quantitative MRI methods for iron overload measurement by multiple sequences have been established, such as proportional signal intensity (SI) methods and proton transverse relaxation rates (R 2 , R 2 *) [4,6,7]. A gradient echo liver-to-muscle SI-based algorithm [8] has been widely validated and used for quantitative liver iron measurement [8][9][10][11].…”

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confidence: 99%

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Iron overload: accuracy of in-phase and out-of-phase MRI as a quick method to evaluate liver iron load in haematological malignancies and chronic liver disease

Virtanen

Pudas²,

Ratilainen³

et al. 2012

BJR

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Objectives: The purpose of this prospective study was to evaluate the accuracy of inphase and out-of-phase imaging to assess hepatic iron concentration in patients with haematological malignancies and chronic liver disease. Methods: MRI-based hepatic iron concentration (M-HIC, mmol g -1 ) was used as a reference standard. 42 patients suspected of having iron overload and 12 control subjects underwent 1.5 T in-and out-of-phase and M-HIC liver imaging. Two methods, semi-quantitative visual grading made by two independent readers and quantitative relative signal intensity (rSI) grading from the signal intensity differences of in-phase and out-of-phase images, were used. Statistical analyses were performed using the Spearman and Kruskal-Wallis tests, receiver operator curves and k coefficients. Results: The correlations between M-HIC and visual gradings of Reader 1 (r50.9534, p,0.0001) and Reader 2 (r50.9456, p,0.0001) were higher than the correlations of the rSI method (r50.7719, p,0.0001). There was excellent agreement between the readers (weighted k50.9619). Both visual grading and rSI were similar in detecting liver iron overload: rSI had 84.85% sensitivity and 100% specificity; visual grading had 85% sensitivity and 100% specificity. The differences between the grades of visual grading were significant (p,0.0001) and the method was able to distinguish different degrees of iron overload at the threshold of 151 mmol g -1 with 100% positive predictive value and negative predictive value. Conclusion: Detection and grading of liver iron can be performed reliably with inphase and out-of-phase imaging. Liver fat is a potential pitfall, which limits the use of rSI.

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Iron overload in the liver diagnostic and quantification

Cited by 64 publications

References 30 publications

Iatrogenic iron overload and its potential consequences in patients on hemodialysis

Iatrogenic iron overload and its potential consequences in patients on hemodialysis

MRI quantification of splenic iron concentration in mouse

Iron overload: accuracy of in-phase and out-of-phase MRI as a quick method to evaluate liver iron load in haematological malignancies and chronic liver disease

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