Iron oxide and gold bimetallic radiosensitizers for synchronous tumor chemoradiation therapy in 4T1 breast cancer murine model

Nosrati, Hamed; Baghdadchi, Yasamin; Abbasi, Reza; Barsbay, Murat; Ghaffarlou, Mohammadreza; Abhari, Fatemeh; Mohammadi, Ali; Kavetskyy, Taras; Bochani, Shayesteh; Rezaeejam, Hamed; Davaran, Soodabeh; Danafar, Hossein

doi:10.1039/d0tb02561e

Cited by 29 publications

(13 citation statements)

References 43 publications

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“…85 As such, FA has been commonly employed to engineer radiosensitizers with active tumor targeting for precision RT. [86][87][88][89][90] For example, Zhang et al loaded sorafenib (SOR, a multi-targeted drug for hepatocellular carcinoma (HCC)) into bismuth-based mesoporous nanomaterials (NBOF) with surface modification of PEG-FA (P-FA) to prepare the NBOF@SOR-P-FA NPs for actively targeted chemoradiotherapy of HCC (Fig. 3a).…”

Section: Enhanced Permeability and Retention (Epr) Effectmediated Pas...mentioning

confidence: 99%

“…The tumor volume ratio in the 64 Cu-Eu/VBBO lipo group was about half of that in the 64 Cu-VBBO lipo group. In addition, other radioisotopes, such as 89 Zr, 86 Y, and 64 Cu, have also been used for PET image-guided RT. [371][372][373][374] Although PET and SPECT can provide functional information with high sensitivity and specificity at the molecular level, PET or SPECT alone is not the most proper imaging technique for cancer diagnosis due to the lack of anatomical information.…”

Section: Radionuclide Image-guided Precision Rtmentioning

confidence: 99%

“…Therefore, the 24 h post-injection was considered as the optimal timepoint for RT of tumors. Besides, the PET/CT imaging based on various radionuclides, such as 86 Zr and 64 Cu, was also utilized to guide precision RT. [378][379][380][381] For example, Achilefu and colleagues coated titanium dioxide NPs (TiO 2 NPs) with transferrin (Tf) and further labeled the NPs with radionuclide 89 Zr ( 89 Zr-TiO 2 -Tf NPs) for bone targeting and PET/CT imagingguided Cerenkov radiation-induced therapy (CRIT) of multiple myeloma (MM, a type of bone-related tumor).…”

Section: Radionuclide Image-guided Precision Rtmentioning

confidence: 99%

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Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

et al. 2022

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Section: Enhanced Permeability and Retention (Epr) Effectmediated Pas...mentioning

confidence: 99%

Section: Radionuclide Image-guided Precision Rtmentioning

confidence: 99%

Section: Radionuclide Image-guided Precision Rtmentioning

confidence: 99%

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Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

et al. 2022

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“…While some studies demonstrated promising results for hybrid nanomaterials [ 12 ], ref. [ 13 ] (typically gold/iron oxide in Janus or core/shell configurations), the use of iron oxide nanoparticles (IONPs) as dose enhancers remains poorly studied, with recent reports mostly focusing on the combination of RT and magnetic hyperthermia [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles’ Radiosensitizing Properties

et al. 2023

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Among the plethora of nanosystems used in the field of theranostics, iron oxide nanoparticles (IONPs) occupy a central place because of their biocompatibility and magnetic properties. In this study, we highlight the radiosensitizing effect of two IONPs formulations (namely 7 nm carboxylated IONPs and PEG5000-IONPs) on A549 lung carcinoma cells when exposed to 225 kV X-rays after 6 h, 24 h and 48 h incubation. The hypothesis that nanoparticles exhibit their radiosensitizing effect by weakening cells through the inhibition of detoxification enzymes was evidenced by thioredoxin reductase activity monitoring. In particular, a good correlation between the amplification effect at 2 Gy and the residual activity of thioredoxin reductase was observed, which is consistent with previous observations made for gold nanoparticles (NPs). This emphasizes that NP-induced radiosensitization does not result solely from physical phenomena but also results from biological events.

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“…In the meanwhile, many different types of metal nanoparticles have been reported as radiosensitizers, such as gold (Huynh et al 2021;Penninckx et al 2020), hafnium oxide (Chen et al 2016;Maggiorella et al 2012), copper (Jiang et al 2018;Liu et al 2017), bismuth (Guo et al 2017;Wang et al 2016), gadolinium (Delorme et al 2017;Mi et al 2015), and iron oxide-based nanoparticles (Nosrati et al 2021;Russell et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Improve the cytotoxic effects of megavoltage radiation treatment by Fe3O4@Cus–PEG nanoparticles as a novel radiosensitizer in colorectal cancer cells

Mohammadian

Minaei

Dezfuli³

2022

Cancer Nano

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Background To enhance the performance of radiotherapy, emerging nanoparticles that can professionally enhance X-ray irradiation to destruct cancer cells are extremely necessary. Here, we examined the potential of PEG-coated magnetite copper sulfide hetero-nanoparticles (Fe3O4@Cus–PEG) as a radiosensitizer agent. Methods Fe3O4@Cus–PEG nanoparticles were synthesized and characterized. The toxicity of nanoparticles on HT-29 colorectal cancer cells was assessed by the MTT assay. The radio-sensitizing effects of Fe3O4@Cus–PEG nanoparticles on HT-29 cancer cells were investigated by the MTT and colony formation assays. Moreover, the underlying mechanisms for Fe3O4@Cus–PEG nanoparticles to improve the radiation sensitivity of cells were evaluated. Results The results demonstrated that nanoparticles enhanced the effects of X-ray irradiation in a dose-dependent manner. The effects of combined treatments (nanoparticles and X-ray radiation) were strongly synergistic. The sensitizing enhancement ratio (SER) of nanoparticles was 2.02. Our in vitro assays demonstrated that the nitric oxide production, the intracellular hydrogen peroxide concentration, and the expression level of Bax and Caspase-3 genes significantly increased in the cells treated with the combination of nanoparticles and radiation. Whereas, the Glutathione peroxidase enzyme activity and the expression level of the Bcl-2 gene in the combined treatment significantly decreased compared to the radiation alone. Conclusions Our study suggests that Fe3O4@Cus–PEG nanoparticles are the promising nano radio-sensitizing agents for the treatment of cancer cells to enhance the efficacy of radiation therapy through increasing the reactive oxygen species generation, nitric oxide production, and inducing apoptosis. Graphical Abstract

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Iron oxide and gold bimetallic radiosensitizers for synchronous tumor chemoradiation therapy in 4T1 breast cancer murine model

Abstract: The development of highly integrated multifunctional nanomaterials with a superadditive therapeutic effect and good safety is an urgent but challenging task in cancer therapy research.

Cited by 29 publications

References 43 publications

Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles’ Radiosensitizing Properties

Improve the cytotoxic effects of megavoltage radiation treatment by Fe3O4@Cus–PEG nanoparticles as a novel radiosensitizer in colorectal cancer cells

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