Iron oxide and gold nanoparticles in cancer therapy

Готман, И.; Psakhie, S. G.; Ложкомоев, А. С.; Gutmanas, E.Y.

doi:10.1063/1.4960239

Cited by 6 publications

(6 citation statements)

References 52 publications

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“…Iron oxide nanoparticles (IONPs) are one of the two most important inorganic nanomaterials, next to gold nanoparticles, owing to their outstanding magnetic properties [95]. GRPR-targeted cancer imaging efficiency of iron oxide nanoparticles is being investigated to a slightly lower extent than gold nanoparticles but considering their clinical success [96] they still pose a great importance in contemporary cancer management, especially in bioimaging of malignant tumors.…”

Section: Iron Oxide Nanoparticlesmentioning

confidence: 99%

Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor

Rurarz¹,

Bukowczyk²,

Gibka³

et al. 2023

Preprint

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Advances in nanomedicine bring the attention of researchers to the molecular targets which can play a major role in the development of novel therapeutic and diagnostic modalities for cancer management. The choice of a proper molecular target can decide on the efficacy of the treatment and endorse the personalized medicine approach. Gastrin-releasing peptide receptor (GRPR) is a G-protein-coupled membrane receptor, well known to be overexpressed in numerous malignancies including pancreatic, prostate, breast, lung, colon, cervical and gastrointestinal cancers. Therefore, many research groups express a deep interest in targeting GRPR with their nanoformulations. A broad spectrum of the GRPR ligands has been described in the literature, which allows tuning of the properties of the final formulation, particularly in the field of the ligand affinity to the receptor and internalization possibilities. Hereby the recent advances in the field of applications of various nanoplatforms which are able to reach the GRPR expressing cells are reviewed.

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Section: Iron Oxide Nanoparticlesmentioning

confidence: 99%

Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor

Rurarz¹,

Bukowczyk²,

Gibka³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Iron oxide nanoparticles (IONPs) are one of the two most important inorganic nanomaterials, next to gold nanoparticles, owing to their outstanding magnetic properties [ 100 ]. GRPR-targeted cancer imaging efficiency of iron oxide nanoparticles is being investigated to a slightly lower extent than gold nanoparticles, but, considering their clinical success [ 101 ], they still pose a great importance in contemporary cancer management, especially in bioimaging of malignant tumors.…”

Section: Molecular Imagingmentioning

confidence: 99%

Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor

Rurarz

Bukowczyk

Gibka

et al. 2023

IJMS

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Advances in nanomedicine bring the attention of researchers to the molecular targets that can play a major role in the development of novel therapeutic and diagnostic modalities for cancer management. The choice of a proper molecular target can decide the efficacy of the treatment and endorse the personalized medicine approach. Gastrin-releasing peptide receptor (GRPR) is a G-protein-coupled membrane receptor, well known to be overexpressed in numerous malignancies including pancreatic, prostate, breast, lung, colon, cervical, and gastrointestinal cancers. Therefore, many research groups express a deep interest in targeting GRPR with their nanoformulations. A broad spectrum of the GRPR ligands has been described in the literature, which allows tuning of the properties of the final formulation, particularly in the field of the ligand affinity to the receptor and internalization possibilities. Hereby, the recent advances in the field of applications of various nanoplatforms that are able to reach the GRPR-expressing cells are reviewed.

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“…The application of inorganic coatings such as gold, silver, or silica can improve the functionality and stability of MNPs in an aqueous solution. For instance, coating IONPs with gold can provide many advantages due to the unique characteristics of gold, such as magnetism, low toxicity, a capability to react with biological molecules, and surface plasmonic resonance which can facilitate optical features [ 95 , 96 ].…”

Section: Surface Coatingmentioning

confidence: 99%

Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects

et al. 2022

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Iron oxide nanoparticle (IONPs) have become a subject of interest in various biomedical fields due to their magnetism and biocompatibility. They can be utilized as heat mediators in magnetic hyperthermia (MHT) or as contrast media in magnetic resonance imaging (MRI), and ultrasound (US). In addition, their high drug-loading capacity enabled them to be therapeutic agent transporters for malignancy treatment. Hence, smartening them allows for an intelligent controlled drug release (CDR) and targeted drug delivery (TDD). Smart magnetic nanoparticles (SMNPs) can overcome the impediments faced by classical chemo-treatment strategies, since they can be navigated and release drug via external or internal stimuli. Recently, they have been synchronized with other modalities, e.g., MRI, MHT, US, and for dual/multimodal theranostic applications in a single platform. Herein, we provide an overview of the attributes of MNPs for cancer theranostic application, fabrication procedures, surface coatings, targeting approaches, and recent advancement of SMNPs. Even though MNPs feature numerous privileges over chemotherapy agents, obstacles remain in clinical usage. This review in particular covers the clinical predicaments faced by SMNPs and future research scopes in the field of SMNPs for cancer theranostics.

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Iron oxide and gold nanoparticles in cancer therapy

Cited by 6 publications

References 52 publications

Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor

Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor

Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor

Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects

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