Iron oxide‐based magnetic nanostructures bearing cytotoxic organosilicon molecules for drug delivery and therapy

Abstract

The results of our own investigation on synthesis, physico-chemical and biological study of iron oxide based magnetic nanoparticles bearing cytotoxic organosilicon molecules of choline and colamine analogues, as potential agents for antitumor therapy, are summarized. These molecules contain hydrophilic head and long lipophilic tails, which are able to deepen inside the first surfactant shell (oleic acid), forming bilayer membrane like structures. Such compositions have a great privilege possessing magnetic properties, which in some cases could be essential moment in targeted drug delivery. The methodological approach has been developed and applied to the preparation of water soluble single or mixed coated biologically active nanoparticles of different types.

Superparamagnetic iron oxide/oleic acid nanoparticles with immobilized organosilicon derivatives of N‐(2‐hydroxyethyl)tetrahydroisoquinoline: synthesis, morphology and interaction with normal and tumour cells

“…Recently model magnetic nanoparticles with immobilized cytotoxic organosilicon choline and colamine derivatives have been synthesized, and water‐based magnetic fluids containing model cytotoxic magnetosomes with amphiphilic trialkylsiloxyalkylamines have been obtained according to the developed original approach. It has been demonstrated that resulting magnetic fluids revealed magnetic properties and affected tumour cell lines . The positive results obtained make it possible to expand the research, involving more complex biologically active molecules using the same principal methodology.…”

“…It has been demonstrated that resulting magnetic fluids revealed magnetic properties and affected tumour cell lines. [20] The positive results obtained make it possible to expand the research, involving more complex biologically active molecules using the same principal methodology.…”

“…The desired superparamagnetic nanoparticles have been obtained according to the recently developed synthetic procedure for linear trialkylsiloxyalkyl amines . Owing to their original unusual magnetosome‐like structure, containing non‐covalently linked silyl prodrugs (the second surfactant) with OA (the first surfactant), complex compositions of this type can be speculated as dual prodrugs; they could be able to ensure the prolonged action of the biologically active compound by the process of gradual desorption, without destroying the whole molecule immediately.…”

Iron oxide superparamagnetic nanocarriers bearing amphiphilic N‐heterocyclic choline analogues as potential antimicrobial agents

“…In our previous research the procedure for the synthesis of model magnetic NPs with immobilized cytotoxic organosilicon choline and colamine derivatives, accepted as silyl pro‐drugs, has been developed and their water‐based magnetic fluids (MFs) have been prepared . It has been demonstrated that the resulting MFs had magnetic properties and affected tumour cell lines . The positive results obtained stimulated us to extend the research to more complex biologically active structures and to other types of biological activity.…”