Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging

Prévot, Geoffrey; Kauss, Tina; Lorenzato, Cyril; Gaubert, Alexandra; Larivière, Mélusine; Baillet, Julie; Laroche‐Traineau, Jeanny; Jacobin‐Valat, Marie‐Josée; Adumeau, Laurent; Mornet, Stéphane; Barthélémy, Philippe; Duonor-Cérutti, Martine; Clofent‐Sanchez, Gisèle; Crauste–Manciet, Sylvie

doi:10.1016/j.ijpharm.2017.09.010

Cited by 19 publications

(23 citation statements)

References 60 publications

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“…This pre-liminary study provided the proof of concept of combining MRI/MPI signals in a targeted nanoprobe for a specific imaging of the atheroma plaque. 156 Other scFv antibody fragments used for the specific targeting of αIIbβ3 integrin have been developed in an array of imaging technologies including MRI, PET, SPECT, and US.…”

Section: Integrin αIibβ3mentioning

confidence: 99%

Recent Advances in the Molecular Imaging of Atherosclerosis

Larivière

Bonnet

Lorenzato

et al. 2020

Semin Thromb Hemost

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Atherosclerosis is the major underlying cause of cardiovascular diseases, the prevalence of which is continuously increasing, thus currently standing as the leading global cause of death. This pathology gradually develops over the course of 50 or more years throughout the life of an individual under the influence of a vast number of factors, both environmental and pathophysiological. This wealth of factors has elicited much research into molecular imaging, with purely diagnostic purposes or with the hope of engineering an efficient theranostic tool. To these ends, diverse nanomaterials with desirable, tunable properties have been explored by different teams, as described in this review.

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Section: Integrin αIibβ3mentioning

confidence: 99%

Recent Advances in the Molecular Imaging of Atherosclerosis

Larivière

Bonnet

Lorenzato

et al. 2020

Semin Thromb Hemost

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“…The dataset of this articles provides information about the engineering of hydrophobic SPION and their loading inside NEs for imaging purpose [1] . Fig.…”

Section: Datamentioning

confidence: 99%

Data on iron oxide core oil-in-water nanoemulsions for atherosclerosis imaging

et al. 2017

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The data presented in this article are related to the publication entitled “Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging” (Prévot et al., 2017) [1]. Herein we describe the synthesis and the characteristics of the Superparamagnetic Iron Oxide Nanoparticles (SPION) loaded inside nanoemulsions (NEs). Focus was set on obtaining SPION with narrow size distribution and close to superparamagnetic limit (20 nm) in order to reach a reasonable magnetic signal. Nanoparticles (NPs) of three different sizes were obtained (7, 11 and 18 nm) and characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), diffuse reflectance infrared Fourier transform (DRIFT) and thermogravimetric analysis (TGA). SPION were coated with oleic acid (OA) in order to load them inside the oily core of NEs droplets. SPION loaded NEs were magnetically sorted using MACS® MS Column (Miltenyi Biotec) and iron quantification was performed by UV-spectrometry measurements.

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“…The dataset of this article provides information about the engineering and purification of a specific human antibody for molecular imaging of atheroma [1] . This human antibody was designed with two cysteines at the Fc site for site-specific grafting.…”

Section: Datamentioning

confidence: 99%

“… This article present data related to the publication entitled “Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging” (Prévot et al, 2017) [1] . Herein we describe the engineering in the baculovirus-insect cell system and purification processes of the human scFv-Fc TEG4-2C antibody, specific of platelets within the atheroma plaque.…”

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confidence: 99%

Data on atherosclerosis specific antibody conjugation to nanoemulsions

Prévot

Duonor-Cérutti²,

Larivière

et al. 2017

Data in Brief

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This article present data related to the publication entitled “Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging” (Prévot et al., 2017) [1]. Herein we describe the engineering in the baculovirus-insect cell system and purification processes of the human scFv-Fc TEG4-2C antibody, specific of platelets within the atheroma plaque. For molecular targeting purpose, atheroma specific antibody was conjugated to nanoemulsions (NEs) using a heterobifunctional linker (DSPE-PEG-maleimide). Atheroma labelling was assayed by immunochemistry on arterial sections from rabbits.

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Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging

Cited by 19 publications

References 60 publications

Recent Advances in the Molecular Imaging of Atherosclerosis

Recent Advances in the Molecular Imaging of Atherosclerosis

Data on iron oxide core oil-in-water nanoemulsions for atherosclerosis imaging

Data on atherosclerosis specific antibody conjugation to nanoemulsions

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