Iron Oxide Magnetic Nanotubes and Their Drug Loading and Release Capabilities

Abstract

Iron oxide magnetic nanomaterials are among the most widely used nanomaterials in nanomedicine. Due to their magnetic and structural properties, iron oxide magnetic nanotubes are extremely attractive for biomedical applications. This paper presents the synthesis of iron oxide magnetic nanotubes, and their potential applications in drug delivery. Three types of iron oxide magnetic nanotubes, i.e., hematite, maghemite, and magnetite, were synthesized using template and hydrothermal methods, and the effects of synthesis methods on the morphological and crystalline properties of the synthesized magnetic nanotubes were analyzed. The magnetization properties of the three types of synthesized magnetic nanotubes and their responses to external magnetic fields were studied. To explore their applications in drug delivery, the drug loading and release capabilities of the synthesized magnetic nanotubes were investigated. The final part of this paper discusses several important issues related to the applications of iron oxide magnetic nanotubes for drug delivery, especially the controlled release of drugs.

Supercritical Synthesis of Poly (2-Dimethylaminoethyl Methacrylate)/Ferrite Nanocomposites and Online Electrochemical Monitoring of Protein Release

“…AIBN initiated polymerization of DMAEMA in presence of MBA in SCC has afforded PDMAEMA with a pair of absorptions at 227 (weak) 245 (strong) nm. Such blue shift in the absorption of PDMAEMA over monomer may be assigned to the loss of the unsaturation of the vinyl functionality as a result of polymerization reaction (Figure 1 (Figure 3a and 3c) [41]. The respective hkl values of FNPs are in close agreement with ASTM data [42].…”

“…The magnetic behavior of materials depends on many factors, such as elemental composition, crystallinity, shape, size and orientation [41]. As the size of the magnetic materials increases, their coercivity and remanence increase accordingly [37].…”

Graphite Coating of Iron Nanowires for Nanorobotic Applications: Synthesis, Characterization and Magnetic Wireless Manipulation

“…Several efforts propose the encapsulation of Fe NWs with carbon coatings for different applications such as magnetic nanosensors and magnetic recording media 16–18. The saturation magnetization ( M S ) of pure Fe is superior to that of most soft magnetic materials, while its biocompatible nature is also advantageous 19–21. Therefore, it is an attractive element to be used in magnetic TDD nanodevices.…”

Electrochemical synthesis and magnetism of magnetic nanotubes

“…Recent applications of magnetic NTs have mainly been focused in the biological field. Chen et al (2010Chen et al ( , 2011cChen et al ( , 2012b demonstrated drug loading and releasing capabilities of hematite, maghemite, and magnetite NTs fabricated using a template-assisted method combined with hydrothermal synthesis, as well as their biocompatibility. Magnetic NTs formed by magnetite NPs embedded in silica NTs were reported by Son et al (2005Son et al ( , 2006 as powerful imaging nanostructures for MRI and to track drug delivery controlled by an external magnetic field and hence directed to specific anatomical sites in vivo (Mitchell et al, 2002).…”