Iron oxide nanoparticles for theranostic applications - Recent advances

Sankaranarayanan, Sri Amruthaa; Thomas, Aswathi; Revi, Neeraja; Ramakrishna, B.; Rengan, Aravind Kumar

doi:10.1016/j.jddst.2022.103196

Cited by 21 publications

(10 citation statements)

References 141 publications

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“…This dual functionality allows IONPs to provide diagnostic insights by enabling their visualization and distribution tracking in vivo via MRI, thereby facilitating guided MHT. [129] IONP-based multifunctional nanoplatforms have shown significant promise in advancing the treatment of atherosclerosis, with an intriguing study conducted by Chandramouli et al offering notable insights. In this study, superparamagnetic iron oxide nanoparticles (SPIONs) were actively targeted to atherosclerotic plaques using an external magnetic field.…”

Section: Magnetic Hyperthermiamentioning

confidence: 99%

Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles

Wang,

He,

Mao

et al. 2024

Advanced Science

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Atherosclerosis, a multifaceted chronic inflammatory disease, has a profound impact on cardiovascular health. However, the critical limitations of atherosclerosis management include the delayed detection of advanced stages, the intricate assessment of plaque stability, and the absence of efficacious therapeutic strategies. Nanotheranostic based on nanotechnology offers a novel paradigm for addressing these challenges by amalgamating advanced imaging capabilities with targeted therapeutic interventions. Meanwhile, iron oxide nanoparticles have emerged as compelling candidates for theranostic applications in atherosclerosis due to their magnetic resonance imaging capability and biosafety. This review delineates the current state and prospects of iron oxide nanoparticle‐based nanotheranostics in the realm of atherosclerosis, including pivotal aspects of atherosclerosis development, the pertinent targeting strategies involved in disease pathogenesis, and the diagnostic and therapeutic roles of iron oxide nanoparticles. Furthermore, this review provides a comprehensive overview of theranostic nanomedicine approaches employing iron oxide nanoparticles, encompassing chemical therapy, physical stimulation therapy, and biological therapy. Finally, this review proposes and discusses the challenges and prospects associated with translating these innovative strategies into clinically viable anti‐atherosclerosis interventions. In conclusion, this review offers new insights into the future of atherosclerosis theranostic, showcasing the remarkable potential of iron oxide‐based nanoparticles as versatile tools in the battle against atherosclerosis.

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Section: Magnetic Hyperthermiamentioning

confidence: 99%

Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles

Wang,

He,

Mao

et al. 2024

Advanced Science

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“…In recent years, synthetic magnetite nanoparticles (MNPs) have been of great interest in a diverse number of applications, ranging from pigments to advanced molecular logic devices. Among the applications of MNPs are biomedical applications, such as in magnetic drug targeting [ 1 , 2 ], as contrast agents for MRI [ 3 ], and in magnetofection [ 4 , 5 ], hyperthermia [ 6 ], DNA/RNA purification [ 7 , 8 ], tissue engineering [ 9 ], theranostic platforms [ 10 , 11 ], smart biosensors [ 12 , 13 ], etc. They also have environmental applications, such as in purifying water [ 14 ], soil [ 15 ], and air [ 16 ] from heavy metals and other industrial pollutions; and optical applications [ 17 ], such as photonic materials [ 18 ], organic light-emitting diodes (OLEDs) [ 19 ], magnetic field sensors [ 20 ], “smart” windows [ 21 ], and solar energy harvesting [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetite-Based Biosensors and Molecular Logic Gates: From Magnetite Synthesis to Application

et al. 2023

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In the last few decades, point-of-care (POC) sensors have become increasingly important in the detection of various targets for the early diagnostics and treatment of diseases. Diverse nanomaterials are used as building blocks for the development of smart biosensors and magnetite nanoparticles (MNPs) are among them. The intrinsic properties of MNPs, such as their large surface area, chemical stability, ease of functionalization, high saturation magnetization, and more, mean they have great potential for use in biosensors. Moreover, the unique characteristics of MNPs, such as their response to external magnetic fields, allow them to be easily manipulated (concentrated and redispersed) in fluidic media. As they are functionalized with biomolecules, MNPs bear high sensitivity and selectivity towards the detection of target biomolecules, which means they are advantageous in biosensor development and lead to a more sensitive, rapid, and accurate identification and quantification of target analytes. Due to the abovementioned properties of functionalized MNPs and their unique magnetic characteristics, they could be employed in the creation of new POC devices, molecular logic gates, and new biomolecular-based biocomputing interfaces, which would build on new ideas and principles. The current review outlines the synthesis, surface coverage, and functionalization of MNPs, as well as recent advancements in magnetite-based biosensors for POC diagnostics and some perspectives in molecular logic, and it also contains some of our own results regarding the topic, which include synthetic MNPs, their application for sample preparation, and the design of fluorescent-based molecular logic gates.

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“…Ferrites transition elements are promising candidates for medical applications due to a successful combination of their technical parameters: ease of synthesis and presence of magnetic properties. Iron oxide compounds exhibit antibacterial properties and are nontoxic [ 8 ], which allows them to be considered as promising materials for theranostics [ 9 , 10 ]. The nanoparticles’ developed surface displays an increased adsorption activity [ 11 ], which can be used for organic–inorganic composite materials synthesis [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Study of the Possibility of Using Sol–Gel Technology to Obtain Magnetic Nanoparticles Based on Transition Metal Ferrites

Shabelskaya

Сулима

Sulima

et al. 2023

Gels

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The article presents results for the magnetic nanoparticles sol–gel method synthesis of cobalt (II) ferrite and organic–inorganic composite materials based on it. The obtained materials were characterized using X-ray phase analysis, scanning and transmission electron microscopy, Scherrer, Brunauer–Emmett–Teller (BET) methods. A composite materials formation mechanism is proposed, which includes a gelation stage where transition element cation chelate complexes react with citric acid and subsequently decompose under heating. The fundamental possibility of obtaining an organo–inorganic composite material based on cobalt (II) ferrite and an organic carrier using the presented method has been proved. Composite materials formation is established to lead to a significant (5–9 times) increase in the sample surface area. Materials with a developed surface are formed: the surface area measured by the BET method is 83–143 m2/g. The resulting composite materials have sufficient magnetic properties to be mobile in a magnetic field. Consequently, wide possibilities for polyfunctional materials synthesis open up for various applications in medicine.

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Iron oxide nanoparticles for theranostic applications - Recent advances

Cited by 21 publications

References 141 publications

Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles

Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles

Magnetite-Based Biosensors and Molecular Logic Gates: From Magnetite Synthesis to Application

Study of the Possibility of Using Sol–Gel Technology to Obtain Magnetic Nanoparticles Based on Transition Metal Ferrites

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