Iron oxide nanoparticles in biological systems: Antibacterial and toxicology perspective

Ezealigo, Uchechukwu S.; Ezealigo, Blessing N.; Aisida, Samson O.; Ezema, Fabian I.

doi:10.1016/j.jciso.2021.100027

Cited by 102 publications

(43 citation statements)

References 146 publications

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“…Wherein, a negative impact is shown starting with total MNPs concentration in the mouse organism of about 140-280 mg kg −1 (20-40 mg kg −1 daily for 1 week), i.e., less than the doses we investigated for cobalt ferrite MNPs. Together with the fact, that in order to increase the stability and biocompatibility of iron oxide MNPs, it is necessary to additionally modify their surface [41], which often leads to deteriorated magnetic properties. Thus, the investigated CoFe Finally, not only the chemical composition of MNPs determines their biocompatibility and heating effectiveness, but also MNPs shape and size.…”

Section: Discussionmentioning

confidence: 99%

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

et al. 2021

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Magnetic nanoparticles (MNPs) are widely considered for cancer treatment, in particular for magnetic hyperthermia (MHT). Thereby, MNPs are still being optimized for lowest possible toxicity on organisms while the magnetic properties are matched for best heating capabilities. In this study, the biocompatibility of 12 nm cobalt ferrite MNPs, functionalized with citrate ions, in different dosages on mice and rats of both sexes was investigated for 30 days after intraperitoneal injection. The animals’ weight, behavior, and blood cells changes, as well as blood biochemical parameters are correlated to histological examination of organs revealing that cobalt ferrite MNPs do not have toxic effects at concentrations close to those used previously for efficient MHT. Moreover, these MNPs demonstrated high specific loss power (SLP) of about 400 W g−1. Importantly the MNPs retained their magnetic properties inside tumor tissue after intratumoral administration for several MHT cycles within three days. Thus, cobalt ferrite MNPs represent a perspective platform for tumor therapy by MHT due to their ability to provide effective heating without exerting a toxic effect on the organism. This opens up new avenues for smaller MNPs sizes while their heating efficiency is maintained.

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Section: Discussionmentioning

confidence: 99%

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

et al. 2021

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“…Moreover, they can be obtained by employing different chemical methods, where IONPs without any surface coating (un-functionalized) are not stable in aqueous media, resulting in a readily aggregate and precipitate [21]. The colloidal suspension of iron oxides (un-functionalized), particularly magnetite, is easily oxidized in air and susceptible to loss of magnetism [11]. Similarly, bare SPIONs may be toxic because they are chemically reactive, so the coating layer prevents aggregation and agglomeration of the NPs and reduces iron oxide oxidation [10].…”

Section: Iron Oxide Nanoparticles (Ionps) and Superparamagnetic Iron ...mentioning

confidence: 99%

“…Polymers 2022, 14, x FOR PEER REVIEW 3 of 27 coating (un-functionalized) are not stable in aqueous media, resulting in a readily aggregate and precipitate [21]. The colloidal suspension of iron oxides (un-functionalized), particularly magnetite, is easily oxidized in air and susceptible to loss of magnetism [11].…”

Section: Iron Oxide Nanoparticles (Ionps) and Superparamagnetic Iron ...mentioning

confidence: 99%

“…IONPs and SPIONs have an iron oxide core coated by an organic or inorganic layer [10] or encapsulated in a polymeric matrix. MNPs are usually functionalized with proteins (amino group), silica, polymer, surfactants, and organic materials to reduce toxicity and optimally fulfill their biomedical functions in drug delivery applications [11]. IONPs have been used to tailor the properties of polymeric hydrogels [12]; meanwhile, the hydrogels acquire a magnetic response.…”

Section: Introductionmentioning

confidence: 99%

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Polymeric Composite of Magnetite Iron Oxide Nanoparticles and Their Application in Biomedicine: A Review

et al. 2022

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A broad spectrum of nanomaterials has been investigated for multiple purposes in recent years. Some of these studied materials are magnetics nanoparticles (MNPs). Iron oxide nanoparticles (IONPs) and superparamagnetic iron oxide nanoparticles (SPIONs) are MNPs that have received extensive attention because of their physicochemical and magnetic properties and their ease of combination with organic or inorganic compounds. Furthermore, the arresting of these MNPs into a cross-linked matrix known as hydrogel has attracted significant interest in the biomedical field. Commonly, MNPs act as a reinforcing material for the polymer matrix. In the present review, several methods, such as co-precipitation, polyol, hydrothermal, microemulsion, and sol-gel methods, are reported to synthesize magnetite nanoparticles with controllable physical and chemical properties that suit the required application. Due to the potential of magnetite-based nanocomposites, specifically in hydrogels, processing methods, including physical blending, in situ precipitation, and grafting methods, are introduced. Moreover, the most common characterization techniques employed to study MNPs and magnetic gel are discussed.

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“…Metallic nanoparticles such as gold MNPs [170], iron [171], and silver [172] have been synthesized, characterized and investigated in several applications, and it has been demonstrated that these materials have very interesting surface, optical and electronic properties. Many types of nanostructured metal oxides, as TiO 2 [173], Fe 2 O 3 [174], Al 2 O 3 [175], ZnO [176], SiO 2 [177], MnO 2 [178], and binary metal oxides [179] were investigated for different applications, demonstrating high potential due to the unique properties offered by nanomaterials.…”

Section: Metallic Nanoparticles and Nanostructured Metal Oxidesmentioning

confidence: 99%

Conversion of Plastic Waste into Supports for Nanostructured Heterogeneous Catalysts: Application in Environmental Remediation

et al. 2021

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Plastics are ubiquitous in our society and are used in many industries, such as packaging, electronics, the automotive industry, and medical and health sectors, and plastic waste is among the types of waste of higher environmental concern. The increase in the amount of plastic waste produced daily has increased environmental problems, such as pollution by micro-plastics, contamination of the food chain, biodiversity degradation and economic losses. The selective and efficient conversion of plastic waste for applications in environmental remediation, such as by obtaining composites, is a strategy of the scientific community for the recovery of plastic waste. The development of polymeric supports for efficient, sustainable, and low-cost heterogeneous catalysts for the treatment of organic/inorganic contaminants is highly desirable yet still a great challenge; this will be the main focus of this work. Common commercial polymers, like polystyrene, polypropylene, polyethylene therephthalate, polyethylene and polyvinyl chloride, are addressed herein, as are their main physicochemical properties, such as molecular mass, degree of crystallinity and others. Additionally, we discuss the environmental and health risks of plastic debris and the main recycling technologies as well as their issues and environmental impact. The use of nanomaterials raises concerns about toxicity and reinforces the need to apply supports; this means that the recycling of plastics in this way may tackle two issues. Finally, we dissert about the advances in turning plastic waste into support for nanocatalysts for environmental remediation, mainly metal and metal oxide nanoparticles.

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Iron oxide nanoparticles in biological systems: Antibacterial and toxicology perspective

Cited by 102 publications

References 146 publications

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

Polymeric Composite of Magnetite Iron Oxide Nanoparticles and Their Application in Biomedicine: A Review

Conversion of Plastic Waste into Supports for Nanostructured Heterogeneous Catalysts: Application in Environmental Remediation

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