Iron oxide nanoparticles with photothermal performance and enhanced nanozyme activity for bacteria-infected wound therapy

Abstract

Metal-based nanomaterials usually have broad-spectrum antibacterial properties, low biological toxicity, and no drug resistance due to their intrinsic enzyme-like catalytic properties and external field (magnetic, thermal, acoustic, optical, electrical) responsiveness. Herein, Iron oxide (Fe3O4) nanoparticles (IONPs) synthesized by us have good biosafety, excellent photothermal conversion ability, and peroxidase-like catalytic activity, which can be used to construct a photothermal-enzymes combined antibacterial treatment platform. IONPs with peroxide-like catalytic activity can induce H2O2 to catalyze the production of •OH in a slightly acidic environment, thus achieving certain bactericidal effects and increasing the sensitivity of bacteria to heat. When stimulated by NIR light, the photothermal effect could destroy bacterial cell membranes, resulting in cleavage and inactivation of bacterial protein, DNA, or RNA. Meanwhile, it can also improve the catalytic activity of peroxidase-like, and promote IONPs to catalyze the production of more •OH for killing bacteria. After IONPs synergistic treatment, the antibacterial rate of Escherichia coli and Staphylococcus aureus reached nearly 100%. It also has an obvious killing effect on bacteria in infected wounds of mice, and can effectively promote the healing of S. aureus-infected wounds, which has great application potential in clinical anti-infection treatment.

Synergistic chemo-/photothermal therapy based on supercritical technology-assisted chitosan–indocyanine green/luteolin nanocomposites for wound healing

“…Recently, several advancements have evidenced novel antimicrobial and antibiofilm therapies, such as photothermal therapy (PTT) [ 8 , 9 ], photodynamic therapy (PDT) [ 10 ] and chemodynamic therapy [ 11 ]. As one of the potent antibacterial and antibiofilm strategies photo-triggered thermal destruction offers enormous advantages, such as membrane disruption, permeability, protein/enzyme denaturation and inhibition of essential intracellular reactions, resulting in irreversible bacterial destruction [ 12 , 13 ].…”

Advances in Nanozymes as a Paradigm for Viral Diagnostics and Therapy

“…Besides, as they are oxides, many additional functional groups can be added to increase the catalytic efficiency of the nanozymes. Furthermore, metal oxide nanoparticles have various advantages, such as the properties like solubility, biodegradable nature, and several other mechanical characteristics of metal oxide nanoparticles can be altered, making them suitable as an efficient therapeutic and diagnostic agent (Q manganese dioxide (MnO2) (Zhao et al, 2022), copper oxide (CuO) (Chen et al, 2022), iron oxide (Fe3O4) (Guo et al, 2022), vanadium pentaoxide (V2O5) (Li et al, 2022), and nanoceria (Singh et al, 2017).…”

Recent advances in regenerative biomaterials

“…One of the concerns in wound healing is to prevent bacterial infections [ 310 , 311 ]. Because infection leads to many severe problems such as chronic wound, researchers tried to employ some biomaterials of photothermal conversion ability, such as iron oxide and PDA, to endow wound dressing with excellent antibacterial effect [ 312 , 313 ]. Zheng et al .…”