Iron oxide/oleic acid magnetic nanoparticles possessing biologically active choline derivatives

Zablotskaya, Alla; Segal, Izolda; Maiorov, Mikhail; Zablotsky, Dmitry; Blums, Elmars

doi:10.1016/b978-0-12-813661-4.00007-9

Cited by 3 publications

(2 citation statements)

References 55 publications

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“…While in this work, we have used hydrocarbon-based fluids synthetically modified by suspending magnetic nanoparticles due to their enhanced stability, magnetic nanofluids can be produced from a broad range of fluids, including aqueous ones [55][56][57], using biocompatible materials [58][59][60][61][62]. Potentially, using the aqueous nanofluids would provide access to versatile manipulation of biological objects [3], such as cells or bacteria [63,64], exploiting the interplay of optothermal thermophoresis and magnetic microflow based on projected light patterns [65].…”

Section: Discussionmentioning

confidence: 99%

Optothermal grid activation of microflow with magnetic nanoparticle thermophoresis for microfluidics

Zablotsky

Mezulis

Blums

et al. 2022

Phil. Trans. R. Soc. A.

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We report focused light-induced activation of intense magnetic microconvection mediated by suspended magnetic nanoparticles in microscale two-dimensional optothermal grids. Fully anisotropic control of microflow and mass transport fluxes is achieved by engaging the magnetic field along one or the other preferred directions. The effect is based on the recently described thermal diffusion–magnetomechanical coupling in synthetic magnetic nanofluids. We expect that the new phenomenon can be applied as an efficient all-optical mixing strategy in integrated microfluidic devices. This article is part of the theme issue ‘Transport phenomena in complex systems (part 2)’.

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Section: Discussionmentioning

confidence: 99%

Optothermal grid activation of microflow with magnetic nanoparticle thermophoresis for microfluidics

Zablotsky

Mezulis

Blums

et al. 2022

Phil. Trans. R. Soc. A.

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“…In addition, oleic acid is biocompatible and completely metabolised. Nanoparticles of iron oxide coated with oleic acid were prepared [38,39], and their cytotoxicity was studied in various cell cultures. The aim of our work was to study the effect of MHT on an in vivo tumour model.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Hyperthermia Nanoarchitectonics via Iron Oxide Nanoparticles Stabilised by Oleic Acid: Anti-Tumour Efficiency and Safety Evaluation in Animals with Transplanted Carcinoma

Kulikov

Zharkov

Ageev

et al. 2022

IJMS

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In this study, we developed iron oxide nanoparticles stabilised with oleic acid/sodium oleate that could exert therapeutic effects for curing tumours via magnetic hyperthermia. A suspension of iron oxide nanoparticles was produced and characterised. The toxicity of the synthesised composition was examined in vivo and found to be negligible. Histological examination showed a low local irritant effect and no effect on the morphology of the internal organs. The efficiency of magnetic hyperthermia for the treatment of transplanted Walker 256 carcinoma was evaluated. The tumour was infiltrated with the synthesised particles and then treated with an alternating magnetic field. The survival rate was 85% in the studied therapy group of seven animals, while in the control group (without treatment), all animals died. The physicochemical and pharmaceutical properties of the synthesised fluid and the therapeutic results, as seen in the in vivo experiments, provide insights into therapeutic hyperthermia using injected magnetite nanoparticles.

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Model colloids to study surface – ligand interactions in nanosized Fe₃O₄

Maiorov

Zablotsky

Blums

et al. 2019

IOP Conf. Ser.: Mater. Sci. Eng.

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Iron oxide/oleic acid magnetic nanoparticles possessing biologically active choline derivatives

Cited by 3 publications

References 55 publications

Optothermal grid activation of microflow with magnetic nanoparticle thermophoresis for microfluidics

Optothermal grid activation of microflow with magnetic nanoparticle thermophoresis for microfluidics

Magnetic Hyperthermia Nanoarchitectonics via Iron Oxide Nanoparticles Stabilised by Oleic Acid: Anti-Tumour Efficiency and Safety Evaluation in Animals with Transplanted Carcinoma

Model colloids to study surface – ligand interactions in nanosized Fe₃O₄

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Iron oxide/oleic acid magnetic nanoparticles possessing biologically active choline derivatives

Cited by 3 publications

References 55 publications

Optothermal grid activation of microflow with magnetic nanoparticle thermophoresis for microfluidics

Optothermal grid activation of microflow with magnetic nanoparticle thermophoresis for microfluidics

Magnetic Hyperthermia Nanoarchitectonics via Iron Oxide Nanoparticles Stabilised by Oleic Acid: Anti-Tumour Efficiency and Safety Evaluation in Animals with Transplanted Carcinoma

Model colloids to study surface – ligand interactions in nanosized Fe3O4

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Model colloids to study surface – ligand interactions in nanosized Fe₃O₄