Iron oxide-pluronic F127 polymer nanocomposites as carriers for a doxorubicin drug delivery system

Mdlovu, Ndumiso Vukile; Mavuso, Fikile Agath; Lin, Kuen‐Song; Chang, Tzu-Wei; Chen, Y.; Wang, Steven S.‐S.; Wu, Chun‐Ming; Mdlovu, Ncobile Bagezile; Lin, Yousheng

doi:10.1016/j.colsurfa.2018.11.052

Cited by 36 publications

(1 citation statement)

References 39 publications

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“…At zero days, very few inflammatory cells were observed, which was referred to as the chronic inflammatory phase in all four groups. On the seventh day of the experiment, small blood vessels were emerging in the wound microenvironment in the drug-loaded hydrogel group and a negligible amount of inflammatory cells were seen compared to the negative and positive control groups, whereas the unloaded injectable hydrogel group also showed few inflammatory cells, showing that the inflammatory phase was complete after seven days in the drug-loaded injectable group [86,87]. Histological analysis confirmed the presence of abundant fibroblasts and granulating cells in the injectable hydrogel groups, while few were present in the control groups [88].…”

Section: Histological Examinationmentioning

confidence: 99%

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

et al. 2022

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The in situ injectable hydrogel system offers a widespread range of biomedical applications in prompt chronic wound treatment and management, as it provides self-healing, maintains a moist wound microenvironment, and offers good antibacterial properties. This study aimed to develop and evaluate biopolymer-based thermoreversible injectable hydrogels for effective wound-healing applications and the controlled drug delivery of meropenem. The injectable hydrogel was developed using the solvent casting method and evaluated for structural changes using proton nuclear magnetic resonance, Fourier transforms infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. The results indicated the self-assembly of hyaluronic acid and kappa-carrageenan and the thermal stability of the fabricated injectable hydrogel with tunable gelation properties. The viscosity assessment indicated the in-situ gelling ability and injectability of the hydrogels at various temperatures. The fabricated hydrogel was loaded with meropenem, and the drug release from the hydrogel in phosphate buffer saline (PBS) with a pH of 7.4 was 96.12%, and the simulated wound fluid with a pH of 6.8 was observed to be at 94.73% at 24 h, which corresponds to the sustained delivery of meropenem. Antibacterial studies on P. aeruginosa, S. aureus, and E. coli with meropenem-laden hydrogel showed higher zones of inhibition. The in vivo studies in Sprague Dawley (SD) rats presented accelerated healing with the drug-loaded injectable hydrogel, while 90% wound closure with the unloaded injectable hydrogel, 70% in the positive control group (SC drug), and 60% in the negative control group was observed (normal saline) after fourteen days. In vivo wound closure analysis confirmed that the developed polymeric hydrogel has synergistic wound-healing potential.

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Section: Histological Examinationmentioning

confidence: 99%

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

et al. 2022

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Preparation of an Injectable Thermosensitive Pluronic F127/ γ‐Fe₂O₃ Hydrogel for Combined Hyperthermia and Localized Drug Delivery for Cancer Treatment

Farzaneh,

Hassanzadeh‐Tabrizi,

Mokhtarian

2024

Polymers for Advanced Techs

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A novel locally injectable hydrogel made from Pluronic F127 containing magnetic γ‐Fe2O3 nanoparticles (GMNP) and Doxorubicin (DOX) with temperature‐sensitive properties for localized magnetic hyperthermia and drug delivery was prepared. In most of the studies that have been observed so far, magnetic nanoparticles have been injected as ferrofluid solutions, but because of the high osmotic pressure inside the tumor, there is a high risk of injection leakage and ferrofluid redistribution. Also, due to the super‐paramagnetic property of nanoparticles, the probability of their agglomeration increases, which causes Atherosclerosis and other problems. The DOX/GMNP/F127 hydrogel exhibited a hyperthermia effect and showed an increase in temperature by applying ACMF (400 kHz). The shape of the GMNPs was spherical, and their size was about 19–51 nm. The mixture was produced as liquid outside the body, but it turned into a gel by increasing the temperature to body temperature. Applying an AC magnetic field on the DOX/GMNP/F127‐gel not only produced controllable heat but also increased the rate of drug release from the gel. Mixing magnetic GMNPs with anticancer DOX drug in the thermo‐responsive F127 hydrogel has emerged as a promising smart combination for the application of simultaneous magnetic hyperthermia and chemotherapy in the possible treatment of cancer.

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Polymeric Nanocomposites for Cancer-Targeted Drug Delivery

Reinhardt

Dias

Gnoatto

et al. 2021

Polymeric and Natural Composites

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Iron oxide-pluronic F127 polymer nanocomposites as carriers for a doxorubicin drug delivery system

Cited by 36 publications

References 39 publications

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

Preparation of an Injectable Thermosensitive Pluronic F127/ γ‐Fe₂O₃ Hydrogel for Combined Hyperthermia and Localized Drug Delivery for Cancer Treatment

Polymeric Nanocomposites for Cancer-Targeted Drug Delivery

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Iron oxide-pluronic F127 polymer nanocomposites as carriers for a doxorubicin drug delivery system

Cited by 36 publications

References 39 publications

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

Preparation of an Injectable Thermosensitive Pluronic F127/ γ‐Fe2O3 Hydrogel for Combined Hyperthermia and Localized Drug Delivery for Cancer Treatment

Polymeric Nanocomposites for Cancer-Targeted Drug Delivery

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Product

Resources

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Preparation of an Injectable Thermosensitive Pluronic F127/ γ‐Fe₂O₃ Hydrogel for Combined Hyperthermia and Localized Drug Delivery for Cancer Treatment