Iron poisoning: Report of three cases and a review of therapeutic intervention

Schauben, Jay L.; Augenstein, W. Lynn; Cox, Jeffrey N.; Sato, Randall

doi:10.1016/0736-4679(90)90012-k

Cited by 23 publications

(8 citation statements)

References 36 publications

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“…Administration of desferrioxamine after acute intoxication may color the urine a pinkish red, a phenomenon termed “ vin rose urine.” Whole bowel irrigation (WBI) may be useful in children if abdominal X-ray reveals radio opaque iron tablets beyond the pylorus or throughout the GI tract. [7] X-ray abdomen in both our patients did not show any radio-opaque pills and WBI was not done.…”

Section: Discussionmentioning

confidence: 69%

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Fatal overdose of iron tablets in adults

Abhilash

Arul

Bala

2013

Indian Journal of Critical Care Medicine

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Acute iron toxicity is usually seen in children with accidental ingestion of iron-containing syrups. However, the literature on acute iron toxicity with suicidal intent in adults is scant. We report, the first instance of two adults with fatal ingestion of a single drug overdose with iron tablets from India. Two young adults developed severe gastro-intestinal bleeding and fulminant hepatic failure 48 h after deliberate consumption of large doses of iron tablets. Serum iron levels measured 36 h after ingestion were normal presumably due to the redistribution of iron to the intracellular compartment. Despite aggressive supportive management in medical intensive care unit of a tertiary care hospital, the patients succumbed to the toxic doses of iron.

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Section: Discussionmentioning

confidence: 69%

“…Ingestion of more than 60 mg/kg is associated with high toxicity and the lethal dose of elemental iron is said to be 200-250 mg/kg. [7]…”

Section: Discussionmentioning

confidence: 99%

Fatal overdose of iron tablets in adults

Abhilash

Arul

Bala

2013

Indian Journal of Critical Care Medicine

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“…In several cases, pregnant women had signs and symptoms of iron poisoning with elevated serum iron levels, were treated with deferoxamine, and delivered healthy infants. [145][146][147][148][149][150][151] Although the placenta transports iron to the fetus efficiently, it blocks the transfer of large quantities of iron. 3 In a sheep model of iron poisoning, only a small amount of iron was transferred across the placenta despite significantly elevated serum iron levels.…”

Section: Is There a Modified Approach To Management In The Pregnant Pmentioning

confidence: 99%

Iron poisoning

Fine¹

2000

Current Problems in Pediatrics

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“…

Acute and chronic iron intoxication are well documented in the general medical literature (1,2,5). However, there are very few references in the obstetric literature to this problem, particularly with respect to treatment with deferoxamine and its consequences (3,8,9,10,11,12).

Case reportA 23 year-old white primigravid woman presented at 221/2 weeks gestation complaining of nausea and malaise that had appeared a few hours after she had ingested 20 tablets of Slow-fe@ (each tablet contains 160 mg exsiccated ferrous sulfate, equivalent to 50 mg ferrous iron, in a slow release tablet). The patient denied that the ingestion had been a suicide attempt.

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mentioning

confidence: 99%

“…Acute and chronic iron intoxication are well documented in the general medical literature (1,2,5). However, there are very few references in the obstetric literature to this problem, particularly with respect to treatment with deferoxamine and its consequences (3,8,9,10,11,12).…”

mentioning

confidence: 99%