Iron profile of pregnant sickle cell anemia patients in Odisha, India

Sukla, Sunil Kumar; Mohanty, P.; Patel, Siris; Das, Kunal; Hiregoudar, Mrutyunjay; Soren, Uttam Kumar; Meher, Satyabrata

doi:10.1016/j.htct.2021.06.012

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…A study conducted in India assessed the iron profile in pregnant women with SCD and reported higher ferritin concentrations in patients compared to healthy controls, which was interesting given the high prevalence of anaemia noted in pregnant women in low-resource settings. 24 In contrast, 90% of adult patients with SCD in a study conducted in Nigeria had normal ferritin concentrations, which is in line with our findings. 25 Given our participants were sampled at steady states (no evidence of ongoing inflammation) and the low CRP levels, these ferritin levels better reflect iron status rather than being influenced by ongoing inflammation.…”

Section: Discussionsupporting

confidence: 90%

“…Although ferritin concentrations tend to increase during the acute phase of inflammation, this was probably not the case among our study cohort as their CRP concentrations were normal. A study conducted in India assessed the iron profile in pregnant women with SCD and reported higher ferritin concentrations in patients compared to healthy controls, which was interesting given the high prevalence of anaemia noted in pregnant women in low‐resource settings 24 . In contrast, 90% of adult patients with SCD in a study conducted in Nigeria had normal ferritin concentrations, which is in line with our findings 25 .…”

Section: Discussionsupporting

confidence: 89%

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Low vitamin B₁₂ blood levels in sickle cell disease: Data from a large cohort study in Tanzania

Kisali,

Iversen,

Makani

2023

Br J Haematol

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SummarySickle cell disease (SCD) is associated with high rates of undernutrition and stunting. Undernutrition in combination with chronic haemolysis may lead to deficiencies in micronutrients necessary for erythropoiesis. Here we examined selected levels of ferritin, vitamins B2, B6, B9 and B12, and vitamin C that were measured in blood samples from 820 SCD patients from Tanzania with no history of hospital admission, infections or painful episodes in the previous 30 days. We studied children (0–8 years), early adolescents (9–14 years), late adolescents (15–17 years) and adults (≥18 years). Severely low levels of vitamin B12 were observed across the four age groups. Despite the lowered vitamin B12 concentrations, total homocysteine concentrations were normal across both genders in all age groups. We found no significant gender‐related differences between the other measured micronutrients. In this large SCD population, spanning the whole life cycle, a low level of vitamin B12 was consistently found across both genders and all age groups. Given the pivotal role of vitamin B12 in cellular metabolism, particularly in erythropoiesis, more studies are required to unravel how to better detect clinically relevant vitamin B12 deficiency among SCD patients, and thus to identify more precisely those who need supplementation of vitamin B12.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Low vitamin B₁₂ blood levels in sickle cell disease: Data from a large cohort study in Tanzania

Kisali,

Iversen,

Makani

2023

Br J Haematol

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“…Gestational anemia was defined according to the criteria outlined by the WHO and CDC. The normal cutoff values of serum iron and TIBC in women without anemia are 10.7 µmol/L (60 µg/dL) [38] and 42.96-80.55 µmol/L (240-450 µg/dL) [39]. The WHO recommends the following cutoff values for gestational anemia: serum ferritin level <0.034 nmol/L (<15 µg/L) [40] and transferrin saturation <16% [41].…”

Section: Anthropometric and Biochemical Parameters In Gestational Anemiamentioning

confidence: 99%

Associations of Dietary Patterns and Vitamin D Levels with Iron Status in Pregnant Women: A Cross-Sectional Study in Taiwan

et al. 2023

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Vitamin D is involved in the pathophysiology of anemia. This cross-sectional study was conducted using the Nationwide Nutrition and Health Survey in Pregnant Women in Taiwan database. We investigated associations among dietary patterns (DPs), vitamin D, and iron-related biomarkers in pregnant women. The principal component analysis revealed four DPs. Linear and logistic regression analyses were performed to investigate the association of DPs with anemia-related biomarkers. Plant-based, carnivore, and dairy and nondairy alternatives DPs were positively associated with serum vitamin D levels. After adjusting covariates, the pregnant women consuming plant-based DPs at the mid-tertile (T2) were associated with reduced risks of low serum folate and vitamin D levels, and those consuming carnivore DPs at higher tertiles (T2 and/or T3) were correlated with an increased risk of low serum iron levels but decreased risks of low serum transferrin saturation, vitamin B12, and vitamin D levels. The pregnant women consuming dairy and nondairy alternatives DPs at the highest tertile (T3) were associated with reduced risks of low serum folate and vitamin B12 levels. However, the processed food DP was not correlated with anemia-related biomarkers. Thus, plant-based, carnivore, and dairy and nondairy alternatives DPs were associated with the risk of low-serum-anemia-related variables.

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“…Valavi et al, (2010) andSukla et al (2021), who reported increase in MCV levels. On the other hand,Omoti et al (2005) reported that the SCA Patients continuously hemolyze their red blood cells, with an erythrocyte survival rate of only 12 to 14 days.…”

mentioning

confidence: 93%

hematological parameters levels study in sickle cell anemia patients in Al-Diwaniyah and Al-Najaf governorates

Al-Khalidi

Ghazzay

2022

ijhs

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Background: Sickle cell anemia a dangerous genetic disorder in which the erythrocytes of the body caused by a mutation in the HBB gene in the sixth position of the β chain, there is a change in the composition of hemoglobin due to the presence of sickle hemoglobin (Hbs). Aim of the study: Is to evaluate the hematological parameters levels in sickle cell anemia condition of patients with sickle cell anemia in the governorates Al- Diwaniyah and Al-Najaf Al-Ashraf. Methods: A total of one hundred and twenty-four subjects were recruited for this study which consists of eighty four sickle cell anemia subjects who (48 males and 36 females) and Forty healthy (20 male and 20 female) subjects as control who matched by age and sex of the patients groups. Conclusion: The outcomes indicated decrease in the level of RBC, Hb, MPV and HCT, while observed increased in the level of WBC, PLT, RDW-SD, RDW-CD, MCV, MCHC and PDW in sickle cell anemia patients compared with the control groups, however observed no significant in level of MCH in sickled patients compared with the control groups.

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Iron profile of pregnant sickle cell anemia patients in Odisha, India

Cited by 6 publications

References 27 publications

Low vitamin B₁₂ blood levels in sickle cell disease: Data from a large cohort study in Tanzania

Low vitamin B₁₂ blood levels in sickle cell disease: Data from a large cohort study in Tanzania

Associations of Dietary Patterns and Vitamin D Levels with Iron Status in Pregnant Women: A Cross-Sectional Study in Taiwan

hematological parameters levels study in sickle cell anemia patients in Al-Diwaniyah and Al-Najaf governorates

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Iron profile of pregnant sickle cell anemia patients in Odisha, India

Cited by 6 publications

References 27 publications

Low vitamin B12 blood levels in sickle cell disease: Data from a large cohort study in Tanzania

Low vitamin B12 blood levels in sickle cell disease: Data from a large cohort study in Tanzania

Associations of Dietary Patterns and Vitamin D Levels with Iron Status in Pregnant Women: A Cross-Sectional Study in Taiwan

hematological parameters levels study in sickle cell anemia patients in Al-Diwaniyah and Al-Najaf governorates

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Low vitamin B₁₂ blood levels in sickle cell disease: Data from a large cohort study in Tanzania

Low vitamin B₁₂ blood levels in sickle cell disease: Data from a large cohort study in Tanzania