Iron-regulatory protein hepcidin is increased in female athletes after a marathon

Roecker, L.; Meier-Buttermilch, R; Brechtel, Lars; Nemeth, Elizabeta; Ganz, Tomas

doi:10.1007/s00421-005-0055-y

Cited by 113 publications

(129 citation statements)

References 14 publications

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…Such an outcome would suggest that 12 h of recovery provides a sufficient amount of time for an athlete to restore their hepcidin activity to resting levels when conducting the type of running training outlined here, since the hepcidin response showed a significant decline in the 12-h post-T2 LSD . This outcome contrasts that of Roecker et al (2005), who found significantly elevated hepcidin levels 24 h after the completion of exercise. This difference may be explained by the duration and intensity of exercise completed, since the participants of Roecker and colleagues ran four times the distance covered during the T2 LSD run, at an average speed that was 26% slower, and for a duration averaging 3 h 44 min longer.…”

Section: Hepcidincontrasting

confidence: 79%

“…However, the levels of the iron-regulatory hormone hepcidin are also increased after exercise (Roecker et al 2005;Peeling et al 2008b). Hepcidin is a liver-produced peptide hormone, up-regulated in response to elevated iron levels and the inflammatory cytokine interleukin-6 (IL-6) (Kemna et al 2005a;Nemeth et al 2004a, b).…”

Section: Introductionmentioning

confidence: 96%

“…Mechanisms such as hemolysis, hematuria, sweating, and gastrointestinal bleeding contribute to this disrupted metabolism of iron (Babić et al 2001;DeRuisseau et al 2002;McInnis et al 1998;Zoller and Vogel 2004). Additionally, recent attention has focused on the post-exercise activity of the ironregulatory hormone hepcidin, suggesting that up-regulation of this hormone may have a negative impact on the body's ability to recycle and absorb dietary iron (Peeling et al 2008a;Roecker et al 2005). Recently, it has been suggested that post-exercise increases in the activity of hepcidin may result from exercise-induced inflammation and/or hemolysis (Peeling et al 2008b).…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity

Peeling

Dawson

Goodman³

et al. 2009

Eur J Appl Physiol

View full text Add to dashboard Cite

The effect of two running sessions completed within a 12-h period on hemolysis, inflammation, and hepcidin activity in endurance athletes was investigated. Ten males completed two experimental trials in a randomized, counterbalanced order. The two trials included (a) a one-running-session trial (T1) including 10 x 1 km interval repeats (90% peak VO2 velocity), and (b) a two-running-session trial (T2), comprising a continuous 10-km run (70% peak VO2 velocity), and a 10 x 1 km interval run (90% peak VO2 velocity) completed 12 h later. Interleukin-6 (IL-6), free hemoglobin (Hb), haptoglobin (Hp), iron, ferritin, and hepcidin were assessed post-exercise. After the T1 and T2 interval runs, free Hb was significantly increased and Hp significantly decreased (p

show abstract

Section: Hepcidincontrasting

confidence: 79%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity

Peeling

Dawson

Goodman³

et al. 2009

Eur J Appl Physiol

View full text Add to dashboard Cite

show abstract

“…Recent studies (14)(15)(16) confirmed a role for hepcidin in regulating iron absorption and suggested that the high prevalence of iron deficiency reported in obese adults (17) may be affected by inflammation-mediated hepcidin release (18). In addition, several studies (19)(20)(21) have shown transient increases in urinary hepcidin concentrations and inflammation after exercise. These studies suggested that high levels of physical training, such as military training, may compromise iron homeostasis.…”

Section: Introductionmentioning

confidence: 94%

Randomized, double-blind, placebo-controlled trial of an iron-fortified food product in female soldiers during military training: relations between iron status, serum hepcidin, and inflammation

Karl

Lieberman

Cable

et al. 2010

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

Background: Iron status degrades in female soldiers during military training. Inflammation-mediated up-regulation of hepcidin, a key mediator of iron homeostasis, may be a contributing factor. Objective: We measured the efficacy of an iron-fortified food product for maintaining iron status in female soldiers during basic combat training (BCT) and examined relations between iron status, serum hepcidin concentrations, and inflammation. Design: A randomized, double-blind, placebo-controlled trial was conducted. Volunteers received an iron-fortified food product (total dose = 56 mg Fe/d) or a placebo twice daily during the 9-wk BCT course. Iron-status indicators, serum hepcidin concentrations, and markers of inflammation were measured pre-and post-BCT. Results: BCT affected iron status; serum ferritin concentrations decreased (P 0.05), and concentrations of soluble transferrin receptor (sTfR) and hemoglobin and the red cell distribution width increased (P 0.05). Consumption of the iron-fortified food product attenuated declines in iron status in iron-deficient anemic soldiers; a group-by-time interaction was observed for hemoglobin and sTfR concentrations (P 0.05). Serum hepcidin concentrations were not affected by BCT; however, hepcidin concentrations were lower in iron-deficient anemic soldiers than in those with normal iron status (P 0.05) and were positively associated with serum ferritin (P 0.05) and C-reactive protein (P 0.05) concentrations pre-and post-BCT. Conclusions: Twice-daily consumption of an iron-fortified food product improved iron status in iron-deficient anemic soldiers but not in iron-normal or iron-deficient nonanemic soldiers. Serum hepcidin concentrations were not affected by training but were associated with iron status and inflammation pre-and post-BCT. This trial was registered at clinicaltrials.gov as NCT01100905.Am J Clin Nutr 2010;92:93-100.

show abstract

“…Blood hepcidin concentration is known to determine the amount of plasma iron availability for the body, by controlling iron export from macrophages and enterocytes. To our knowledge, the only types of exercise which have been explored for hepcidin variations are the marathon race (more than 4 h) of female athletes and the 10-km run of male athletes (70-90% VO 2 ) where hepcidin concentration increased despite marked interindividual variations (Peeling et al 2009;Roecker et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism

et al. 2009

View full text Add to dashboard Cite

Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes. Hepcidin and HJV are highly expressed in liver and muscles, respectively. Intensive muscular exercise has been reported to modify serum iron parameters and to increase hepcidinuria. The present study aimed at evaluating the potential impact of low intensity muscle exercise on iron metabolism and on hepcidin, its key regulator. Fourteen normal volunteers underwent submaximal cycling-based exercise in a crossover design and various iron parameters, including serum and urinary hepcidin, were serially studied. The results demonstrated that submaximal ergocycle endurance exercise did not modulate hepcidin. This study also indicated that hepcidinuria did not show any daily variation whereas serum hepcidin did. The findings, by demonstrating that hepcidin concentrations are not influenced by submaximal cycling exercise, may have implications for hepcidin sampling in medical practice.

show abstract

Iron-regulatory protein hepcidin is increased in female athletes after a marathon

Cited by 113 publications

References 14 publications

Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity

Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity

Randomized, double-blind, placebo-controlled trial of an iron-fortified food product in female soldiers during military training: relations between iron status, serum hepcidin, and inflammation

Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism

Contact Info

Product

Resources

About