Iron requirement in the infection of Salmonella and its relevance to poultry health

Tan, Zhigang; Lu, Peng; Adewole, Deborah; Diarra, Moussa S.; Gong, Joshua; Yang, Chengbo

doi:10.1016/j.japr.2020.09.016

Cited by 14 publications

(7 citation statements)

References 199 publications

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“…Anti-inflammatory agents can help reduce inflammation and therefore reduce hepcidin levels, which may increase serum iron levels ( Stoffel et al, 2021 ). Hepcidin is a protein consisting of 25 amino acids and is produced both by hepatocytes during inflammation and also by infected macrophages ( Tan et al, 2021 ). Hepcidin and ferroportin are present in most of the vertebrate genomes available, including the chicken, and evidence for a hepcidin-ferroportin axis in avian iron metabolism has been found ( Klasing et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Regression-derived optimal milk thistle in growing quail's diet

Ghazaghi,

Isazaei,

Bagherzadeh-Kasmani

et al. 2024

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Regression-derived optimal milk thistle in growing quail's diet

Ghazaghi,

Isazaei,

Bagherzadeh-Kasmani

et al. 2024

Poultry Science

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“…It is known that controlling the iron content in poultry diets is an effective way to prevent large-scale growth of Salmonella spp. in the intestine (Tan et al, 2021). Different studies have shown that iron bioavailability determines the growth rates of Salmonella cells in liquid eggs (Gast and Holt, 1995;Guillén and Cebrián, 2022).…”

Section: Discussionmentioning

confidence: 99%

Salmonella spp. isolation from different types of egg samples and antimicrobial resistance of these strains in Argentina

2024

Ger. J. Microbiol.

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We studied the serovars present and the performance of two selective plating media, Hektoen enteric agar (HE) and Xylose-Lysine-Desoxycholate (XLD) agar, as well as the time of tetrathionate broth incubation (one and five days) used for Salmonella isolation in different samples of egg and egg packs collected from supermarkets in Argentina. We also determined the occurrence of bacterial growth inhibitors in egg content and the antibiotic resistance profile of the isolated strains. Salmonella spp. was detected in 29 samples (1.8%) from 1,643 different types of egg and egg pack samples analyzed. Eight serovars of Salmonella were isolated: S. ser. Typhimurium (ST), S. ser. Enteritidis (SE), S. ser. Agona, S. ser. Westhampton, S. ser. Brandenburg, S. ser. Gallinarum (biovar Gallinarum), S. ser. Muenchen, and S. ser. Montevideo. The most frequent were ST and SE; both were present in eggshells, yolk, and albumen. The increase in the incubation time in tetrathionate broth affected the isolation of Salmonella spp. from eggshell and pool of yolk and albumen with different values of relative sensitivity and accuracy (p<0.05). Furthermore, there was a significant difference between the two-plating media at the time of tetrathionate broth incubation in eggshell for the relative sensitivity (p<0.05). The agreement between XLD and HE agar in relation to the time of tetrathionate broth incubation depended on the type of samples studied. The occurrence of bacterial growth inhibitors in yolk and albumen depended on bacteria assayed. However, these were presented in yolk and albumen from the same pool of egg content. There were 2 and 8 different patterns of resistance among Salmonella strains isolated, and 87% of these strains were multidrug-resistant. It is necessary to understand the epidemiology of Salmonella from eggs and to alert public health to minimize the prevalence of antibiotic resistance of Salmonella spp. in Argentina.

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“…Interestingly, salmonellosis shows an association between high socioeconomic status and illness (Leon et al, 2015). Additionally, Salmonella is notorious as an enteric pathogen that infects a wide range of animal hosts, contributing to the deterioration of animal health, compromised animal welfare, enormous agricultural losses, and a signi cant medical burden worldwide (Tan et al, 2021). Thus, Salmonella infections pose a formidable threat to both public and animal health, incurring substantial annual costs.…”

Section: Introductionmentioning

confidence: 99%

Myeloid NCOA4 sequesters KEAP1 to reduce ferroptosis for protection against salmonellosis in mice.

Xue,

Arcos,

Liu

et al. 2024

Preprint

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Salmonellosis is a severe infection caused by Salmonella enterica serovar Typhimurium, leading to significant global morbidity and mortality. Host nutrition immunity restricts extracellular bacterial replication by reducing iron availability through the induction of the antimicrobial hormone hepcidin. Hepcidin degrades the iron exporter ferroportin, limiting intestinal iron uptake and reducing iron transfer into the blood. Paradoxically, this defense mechanism increases iron storage in macrophages, fostering an environment conducive to intracellular pathogens like Salmonella to proliferate and disseminate. Mice lacking the iron storage protein ferritin heavy chain (FTH1) in myeloid cells exhibit worsened Salmonella infection. Nuclear receptor co-activator 4 (NCOA4) directs FTH1 autophagic degradation to release iron from storage during conditions of low iron. However, the role of myeloid NCOA4 in regulating salmonellosis and gut pathophysiology remains unclear. Here, we reveal that myeloid NCOA4 deficiency augments spleen iron levels and increases cellular iron accumulation, oxidative stress, and ferroptosis in bone marrow-derived macrophages (BMDM) cells. This deficiency also increases susceptibility to Salmonella-induced colitis in mice due to exacerbated oxidative stress and ferroptosis. Mechanistically, NCOA4 suppresses oxidative stress by directly binding to the E3 ubiquitin ligase Kelch-like ECH-associated protein 1 (KEAP1) and stabilizing the antioxidant transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2). Activation of NRF2 protects myeloid NCOA4 knockout mice from Salmonella-induced colitis. Antioxidants Tempol and curcumin offer protection against colitis in myeloid NCOA4-deficient mice. A low iron diet and ferroptosis inhibition also mitigate the heightened colitis in these mice. Overexpression of myeloid cell-specific NCOA4 confers protection against Salmonella-induced colitis via upregulating NRF2 signaling. Together, this study not only advances our understanding of myeloid iron metabolism but also paves the way for novel myeloid cell-targeted therapies to combat salmonellosis.

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Iron requirement in the infection of Salmonella and its relevance to poultry health

Cited by 14 publications

References 199 publications

Regression-derived optimal milk thistle in growing quail's diet

Regression-derived optimal milk thistle in growing quail's diet

Salmonella spp. isolation from different types of egg samples and antimicrobial resistance of these strains in Argentina

Myeloid NCOA4 sequesters KEAP1 to reduce ferroptosis for protection against salmonellosis in mice.

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