Iron scavenging and myeloid cell polarization

Ludwig, Natalie; Cucinelli, Stefania; Hametner, Simon; Muckenthaler, Martina U.; Schirmer, Lucas

doi:10.1016/j.it.2024.06.006

Trends in Immunology

2024

DOI: 10.1016/j.it.2024.06.006

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Iron scavenging and myeloid cell polarization

Natalie Ludwig,

Stefania Cucinelli,

Simon Hametner

et al.

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2024

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Depletion of macrophages and osteoclast precursors mitigates iron overload‐mediated bone loss

Passin,

Ledesma‐Colunga,

Altamura

et al. 2024

IUBMB Life

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Iron is an essential element for physiological cellular processes, but is toxic in excess. Iron overload diseases are commonly associated with low bone mass. Increased bone resorption by osteoclasts as well as decreased bone formation by osteoblasts have been implicated in bone loss under iron overload conditions. However, the exact contribution of individual cell types has not yet been formally tested. In this study, we aimed to investigate the role of osteoclast precursors in iron overload‐induced bone loss. To that end, we used clodronate liposomes to deplete phagocytic cells (including macrophages and osteoclast precursors) in male C57BL/6J mice that were exposed to ferric derisomaltose. Bone microarchitecture and bone turnover were assessed after 4 weeks. The application of clodronate resulted in the efficient depletion of circulating myeloid‐lineage cells by about 70%. Depletion of osteoclast precursors mitigated iron overload‐induced trabecular bone loss at the lumbar vertebrae and distal femur. While clodronate treatment led to a profound inhibition of bone turnover in control mice, it significantly reduced osteoclast numbers in iron‐treated mice without further impacting the bone formation rate or serum PINP levels. Our observations suggest that even though bone formation is markedly suppressed by iron overload, osteoclasts also play a key role in iron overload‐induced bone loss and highlight them as potential therapeutic targets.

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Depletion of macrophages and osteoclast precursors mitigates iron overload‐mediated bone loss

Passin,

Ledesma‐Colunga,

Altamura

et al. 2024

IUBMB Life

View full text Add to dashboard Cite

show abstract

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Iron scavenging and myeloid cell polarization

Cited by 1 publication

References 100 publications

Depletion of macrophages and osteoclast precursors mitigates iron overload‐mediated bone loss

Depletion of macrophages and osteoclast precursors mitigates iron overload‐mediated bone loss

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