Iron(<scp>iii</scp>) chelated paramagnetic polymeric nanoparticle formulation as a next-generation<i>T</i><sub>1</sub>-weighted MRI contrast agent

Marasini, Ramesh; Rayamajhi, Sagar; Moreno-Sanchez, Anthony; Aryal, Santosh

doi:10.1039/d1ra05544e

Cited by 13 publications

(10 citation statements)

References 59 publications

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“…As shown in Figure f, the aqueous solutions of FD–Mn–FD and MnCl 2 obtained very bright T 1 -weighted MRI images and showed higher MRI contrast than FD and FD–Mn–O 2 NO at the same concentrations. Furthermore, FD–Mn–FD showed signal enhancement on T 1 -weighted images in a concentration-dependent manner and exhibited better T 1 positive contrast . The complexes inevitably have a rapid hydrolysis equilibrium in solution, so the MRI of both FD–Mn–FD and FD–Mn–O 2 NO has the contribution of free Mn 2+ .…”

Section: Resultsmentioning

confidence: 97%

Coordination-Regulated Terpyridine–Mn(II) Complexes for Photodynamic Therapy Guided by Multiphoton Fluorescence/Magnetic Resonance Imaging

et al. 2022

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The synergy of multiphoton fluorescence imaging (MP-FI) and magnetic resonance imaging (MRI) provides an imaging platform with high resolution and unlimited penetration depth for early disease detection. Herein, two kinds of terpyridine–Mn(II) complexes (FD–Mn–O 2 NO and FD–Mn–FD) possessing seven and six coordination modes, respectively, were designed rationally for photodynamic therapy (PDT) guided by MP-FI/MRI. The complexes obtain different multiphoton fluorescence/magnetic resonance properties by adjusting the number of terpyridine ligands. Among them, FD–Mn–FD exhibits the following superiorities: (1) The optimal three-photon excitation wavelength of FD–Mn–FD falls at 1450 nm (NIR-II), which brings high sensitivity and deep tissue penetration in MP-FI. (2) FD–Mn–FD has effective longitudinal relaxation efficiency (r 1 = 2.6 m M–1 s–1), which can be used for T 1-weighted MRI, overcoming the problems of limited tissue penetration depth and low spatial resolution. (3) FD–Mn–FD generates endogenous 1O2 under irradiation by 808 nm light, thereby enhancing the PDT effect in vitro and in vivo. To the best of our knowledge, the complex FD–Mn–FD is the first complex to guide PDT through MP-FI/MRI, providing a blueprint for accurate and effective early detection and timely treatment of the complex in the early stages of cancer.

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Section: Resultsmentioning

confidence: 97%

Coordination-Regulated Terpyridine–Mn(II) Complexes for Photodynamic Therapy Guided by Multiphoton Fluorescence/Magnetic Resonance Imaging

et al. 2022

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“…86 Paramagnetic Fe(III)-ion-chelated poly(lactic acid-co-glycolic acid) NPs were formulated for MRI diagnostic applications. 87 The clinically relevant magnetic field relaxivity of these NCAs (∼130 ± 12 nm) with high monodispersity and stability, at physiological pH, of the NPs was 3 times higher than Magnevist. Their relaxivity in an aqueous environment was r 1 = ∼10.59 ± 0.32 mmol −1 s −1 and r 1 = ∼ 3.02 ± 0.14 mmol −1 s −1 at 3.0 and 14.1 T determined at room temperature and pH 7.4, respectively.…”

Section: Ncas For Mrimentioning

confidence: 90%

“…No long-term retention of these nanoagents could be detected in the organs of examined mice . Paramagnetic Fe(III)-ion-chelated poly(lactic acid- co -glycolic acid) NPs were formulated for MRI diagnostic applications . The clinically relevant magnetic field relaxivity of these NCAs (∼130 ± 12 nm) with high monodispersity and stability, at physiological pH, of the NPs was 3 times higher than Magnevist.…”

Section: Ncas For Mrimentioning

confidence: 99%

“…Their relaxivity in an aqueous environment was r 1 = ∼10.59 ± 0.32 mmol –1 s –1 and r 1 = ∼ 3.02 ± 0.14 mmol –1 s –1 at 3.0 and 14.1 T determined at room temperature and pH 7.4, respectively. Suitable biodegradability and biocompatibility of the applied components in this introduced nanosystem make it a very promising T 1 agent for contrast-enhanced MRI of various diseases …”

Section: Ncas For Mrimentioning

confidence: 99%

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Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

Soufi

Hekmatnia

Iravani

et al. 2022

ACS Appl. Nano Mater.

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Today, magnetic resonance imaging (MRI) is one of the most widely applied noninvasive clinical imaging modalities with excellent applicability in bio- and nanomedicine, particularly in specific detecting and high-quality three-dimensional imaging of tumors/cancers. In this context, the design of efficient nanoscale contrast agents (NCAs) for MRI with high magnetic relaxivity and specificity/selectivity has garnered immense interest deploying a variety of innovatively designed nanostructures. Some important characteristics of NCAs such as biocompatibility, improved relaxivity, high dispersibility, specific targeting, and low toxicity make them ideal candidates for imaging/biosensing applications. The hybridization and surface functionalization/modification of these materials by applying suitable functional groups/agents can help to improve their properties and multifunctionality. However, there is still a long way to go in the clinical applications of these nanoagents to serve as a substitute for Gd-based contrast agents or other commercial materials. Importantly, nanotoxicological and biosafety issues of these NCAs need to be systematically addressed both at pre- and clinical stages; construction of smart multifunctional NCAs with clinical diagnostic and imaging potentials is thus warranted. Herein, recent advancements related to the diagnostic and imaging applications of MRI NCAs are deliberated, focusing on important challenges and future directions.

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“…PLGA with a carboxylic acid-terminated end group of molecular weight 50 kDa was used to synthesize IR-820 encapsulated PLGA nanoparticles following the well-established nanoprecipitation protocol. − In a typical experiment, the calculated amount of IR-820 in DMSO was physically adsorbed with 1 mg of PLGA in acetonitrile and made the final volume of the mixture to 1 mL to prepare IR-820-encapsulated PLGA nanoparticles. Then the phospholipids that consist of lipid mixture formulations having 260 μg of DSPE-PEG and 200 μg of DSPG were used in 4% ethanol, respectively.…”

Section: Methodsmentioning

confidence: 99%

Indocyanine-type Infrared-820 Encapsulated Polymeric Nanoparticle-Assisted Photothermal Therapy of Cancer

Marasini

Aryal

2022

ACS Omega

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Organic small-molecule photosensitizers are well-characterized and known for the light-responsive treatment modality including photodynamic therapy. Compared with ultraviolet–visible (UV–vis) light used in conventional photodynamic therapy with organic photosensitizers, near-infrared (NIR) light from 700 to 900 nm is less absorbed and scattered by biological tissue such as hemoglobin, lipids, and water, and thus, the use of NIR excitation can greatly increase the penetration depth and emission. Additionally, NIR light has lower energy than UV–vis that can be beneficial due to less activation of fluorophores present in tissues upon NIR irradiation. However, the low water stability, nonspecific distribution, and short circulation half-life of the organic photosensitizers limit its broad biological application. NIR responsive small-molecule fluorescent agents are the focus of extensive research for combined molecular imaging and hyperthermia. Recently a new class of NIR dye, IR-820 with excitation and emission wavelengths of 710 and 820 nm, has been developed and explored as an alternative platform to overcome some of the limitations of the most commonly used gold nanoparticles for photothermal therapy of cancer. Herein, we synthesized a core–shell biocompatible nanocarrier envelope made up of a phospholipid conjugated with poly(ethylene glycol) as a shell, while poly(lactic glycolic acid) (PLGA) was used as a core to encapsulate IR-820 dye. The IR-820-loaded nanoparticles were prepared by nanoprecipitation and characterized for their physicochemical properties and photothermal efficiency. These nanoparticles were monodispersed and highly stable in physiological pH with the hydrodynamic size of 103 ± 8 nm and polydispersity index of 0.163 ± 0.031. The IR-820-loaded nanocarrier showed excellent biocompatibility in the dark, whereas remarkable phototoxicity was observed with breast cancer cells (MCF-7) upon NIR laser excitation. Therefore, the IR-820-loaded phospholipid mimicking biodegradable lipid-polymer composite nanoparticles could have great potential for cancer theranostics.

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Iron(iii) chelated paramagnetic polymeric nanoparticle formulation as a next-generationT₁-weighted MRI contrast agent

Abstract: In pursuit of safer alternatives to Gd-based MRI contrast agents due to its toxicity and organ deposition, herein, we developed a safer and efficient clinically relevant iron(iii) chelated polymeric nanoparticle as a T1-weighted MRI contrast agent.

Cited by 13 publications

References 59 publications

Coordination-Regulated Terpyridine–Mn(II) Complexes for Photodynamic Therapy Guided by Multiphoton Fluorescence/Magnetic Resonance Imaging

Coordination-Regulated Terpyridine–Mn(II) Complexes for Photodynamic Therapy Guided by Multiphoton Fluorescence/Magnetic Resonance Imaging

Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

Indocyanine-type Infrared-820 Encapsulated Polymeric Nanoparticle-Assisted Photothermal Therapy of Cancer

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Iron(iii) chelated paramagnetic polymeric nanoparticle formulation as a next-generationT1-weighted MRI contrast agent

Abstract: In pursuit of safer alternatives to Gd-based MRI contrast agents due to its toxicity and organ deposition, herein, we developed a safer and efficient clinically relevant iron(iii) chelated polymeric nanoparticle as a T1-weighted MRI contrast agent.

Cited by 13 publications

References 59 publications

Coordination-Regulated Terpyridine–Mn(II) Complexes for Photodynamic Therapy Guided by Multiphoton Fluorescence/Magnetic Resonance Imaging

Coordination-Regulated Terpyridine–Mn(II) Complexes for Photodynamic Therapy Guided by Multiphoton Fluorescence/Magnetic Resonance Imaging

Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

Indocyanine-type Infrared-820 Encapsulated Polymeric Nanoparticle-Assisted Photothermal Therapy of Cancer

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Iron(iii) chelated paramagnetic polymeric nanoparticle formulation as a next-generationT₁-weighted MRI contrast agent