Iron status and its association with pregnancy outcome in Korean pregnant women

Lee, H S; Kim, M S; Kim, M H; Kim, Y J; Kim, W Y

doi:10.1038/sj.ejcn.1602429

Cited by 62 publications

(65 citation statements)

References 26 publications

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“…Epidemiological studies have shown that maternal iron deficiency is associated with increased incidence of IUGR (141,142) . Large placental weights and a high ratio of placental weight to birth-weight are observed (143) .…”

Section: Maternal Iron Restrictionmentioning

confidence: 99%

The impact of early nutrition on the ageing trajectory

Tarry-Adkins

Ozanne

2014

Proc. Nutr. Soc.

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Epidemiological studies, including those in identical twins, and in individuals in utero during periods of famine have provided robust evidence of strong correlations between low birthweight and subsequent risk of disease in later life, including type 2 diabetes (T2D), CVD, and metabolic syndrome. These and studies in animal models have suggested that the early environment, especially early nutrition, plays an important role in mediating these associations. The concept of early life programming is therefore widely accepted; however the molecular mechanisms by which early environmental insults can have long-term effects on a cell and consequently the metabolism of an organism in later life, are relatively unclear. So far, these mechanisms include permanent structural changes to the organ caused by suboptimal levels of an important factor during a critical developmental period, changes in gene expression caused by epigenetic modifications (including DNA methylation, histone modification and microRNA) and permanent changes in cellular ageing. Many of the conditions associated with early-life nutrition are also those which have an age-associated aetiology. Recently, a common molecular mechanism in animal models of developmental programming and epidemiological studies has been development of oxidative stress and macromolecule damage, specifically DNA damage and telomere shortening. These are phenotypes common to accelerated cellular ageing. Thus, this review will encompass epidemiological and animal models of developmental programming with specific emphasis on cellular ageing and how these could lead to potential therapeutic interventions and strategies which could combat the burden of common age-associated disease, such as T2D and CVD.

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Section: Maternal Iron Restrictionmentioning

confidence: 99%

The impact of early nutrition on the ageing trajectory

Tarry-Adkins

Ozanne

2014

Proc. Nutr. Soc.

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“…3,4 The prevalence of anemia and micromineral-vitamin deficiencies in pregnant women differs considerably depending on their lifestyle and cultural and socioeconomic status. 5 Previous controlled randomized studies have identified important improvements in pregnancy outcomes after the utilization of a supplemental diet. 6,7 In some developed countries, over-Between 20 and 30 percent of pregnant women suffer from at least one kind of vitamin deficiency.…”

Section: Introductionmentioning

confidence: 99%

Prenatal multivitamin supplementation increases birth weight

Kalem

Kamalak²,

Köşüş³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: The aim of this study is to examine whether there is any positive impact of prenatal iron and vitamin supplementation on birth weight, and if this practice could be a cause of macrosomia.Methods: A total of 1,838 term pregnant women were included in this study and were divided into four groups: iron group (women having only iron supplementation), vitamin (women using only multivitamins), vitamin+iron (women using both iron and multivitamin preparations), and control group (women having neither iron nor vitamin supplements). Statistical analysis was performed to compare age, gravida, parity, hemoglobin, BMI and birth weight. Groups were compared in terms of macrosomia and correlation analysis carried out between demographics and birth weight.Results: The birth weight was significantly higher in the vitamin group and the vitamin+iron group than in the iron group and the control group. Vitamin supplementation increased the risk of macrosomia 3.9 times, while vitamin+iron usage increased the risk 4.8 times.Conclusions: Uncontrolled use of multivitamins and/or iron supplements may increase tendency for fetal macrosomia. The use of multivitamins and/or iron supplements by pregnant women must take into account maternal age, maternal diet and maternal BMI. Our findings support a reduction in the unnecessary use of vitamin and iron supplements in pregnancy, and a reversal of the trend to start vitamin and iron supplementation without any control. The increasing prevalence of obesity and excessive weight in pregnant women should be a warning against the uncontrolled usage of vitamins and iron during pregnancy.

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“…A review of longitudinal studies indicated that children who were anaemic in early childhood continued to have poor cognition and school performance in middle childhood, compared with nonanaemic children 5 . Severe anaemia during pregnancy is strongly related to increased risks of low birth weight, preterm birth and perinatal mortality 6,7 . Iron deficiency, even without anaemia, is also associated with reduced physical performance and work capacity 8 .…”

mentioning

confidence: 99%

“…Common causes of anaemia, other than iron deficiency, include other vitamin deficiencies (e.g. vitamin B 12 , B 6 , folate and C) 4 . Anaemia of chronic disease, a condition accompanied by inflammation, is present in some people, including young children 4 .…”

mentioning

confidence: 99%

Trends in the prevalence of anaemia in Japanese adult women, 1989–2003

Hayashi

Yoshiike

Yoshita

et al. 2008

Public Health Nutr.

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Objective: There is an increasing concern of anaemia in Japanese women, but no national trend data has existed to date. We analysed long-term national trends of anaemia in adult women. Design: Secondary analyses of 15 consecutive cross-sectional nationwide surveys conducted during the period 1989-2003. Analyses were based on 5-year intervals (1989-1993, 1994-1998, 1999-2003). Setting: Japan. Subjects: The subjects included the National Health and Nutrition Survey of Japan (NHNS-J) population. Analyses were based on 50 967 non-pregnant/non-lactating women aged 20 years and over, with complete data sets. We stratified subjects into six age groups (20-29 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years and 701 years), and three age groups (20-49 years, 50-69 years, 701 years) for analyses on residential areas (metropolitan, cities and towns). Results: Decreases in trends of mean haemoglobin values (intravenous) were significant in all age groups. Changes in the prevalence of anaemia were significant only in women aged 30-39 and 40-49 years. Anaemia (haemoglobin , 12.0 g dl 21 ) increased from 16.8% to 20.6% in women aged 30-39 years, and from 20.2% to 26.9% in women aged 40-49 years, respectively. Prevalence was highest in women aged 70 years and older in all times, but no significant change was observed. Conclusions: Haemoglobin values have declined significantly in all ages in the last 15 years. Anaemia was especially significant in women aged 30-39 years and 40-49 years. Our findings suggest that a large number of young women in Japan are at risk of anaemia, so continuous monitoring and controlling efforts of this trend are needed.

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Iron status and its association with pregnancy outcome in Korean pregnant women

Cited by 62 publications

References 26 publications

The impact of early nutrition on the ageing trajectory

The impact of early nutrition on the ageing trajectory

Prenatal multivitamin supplementation increases birth weight

Trends in the prevalence of anaemia in Japanese adult women, 1989–2003

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