Iron Status and Its Determinants in a Nationally Representative Sample of Pregnant Women

Vandevijvere, Stefanie; Amsalkhir, Sihame; Oyen, Herman Van; Egli, Ines; Moreno‐Reyes, Rodrigo

doi:10.1016/j.jand.2012.10.021

Cited by 32 publications

(35 citation statements)

References 22 publications

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“…That is, iron supplementation might be erroneously recommended by health professionals who are not certain what type of anemia is to be treated in pregnant women [47,52]. Many authors disagree that maternal anemia might be representative of iron deficiency anemia because some studies show discrepancies in the prevalence of both types of anemia [4,6,7,16,21,43]. Such research shows that the occurrence of iron deficiency anemia is, in most investigations, expressly lower than that of maternal anemia [4,6,7,16,21,43].…”

Section: Is Iron Deficiency Anemia a Proxy For Maternal Anemia?mentioning

confidence: 99%

“…Studies that use serum ferritin and/or transferrin levels to diagnose iron deficiency anemia report results that are more consistent for the population of pregnant women [4,6,7,16,21,52] than studies that used only hemoglobin levels [5,[13][14][15]. The WHO maternal anemia criteria are considered inappropriate by some authors, when there is the intention to estimate iron deficiency anemia [2,4,6,7,21]. This issue is related to the disease pathophysiology, given that the origin of maternal anemia might not be iron deficiency but other uninvestigated causes.…”

Section: Is Iron Deficiency Anemia a Proxy For Maternal Anemia?mentioning

confidence: 99%

“…As a result of this discussion, anemia has become a priority for many countries, with the main goal being its reduction across different population groups [3]. There are many studies with different methodological strategies focusing on anemia [4][5][6][7][8][9][10][11][12]. Such studies include distinct population subgroups and different sample sizes, producing conflicting results [12].…”

Section: Introductionmentioning

confidence: 99%

“…While some studies consider hemoglobin level the only diagnostic criterion for iron deficiency anemia, other studies show that the frequency of iron deficiency is lower when diagnosed using both hemoglobin and ferritin levels [5][6][7][13][14][15][16]. Therefore, there is no consensus that maternal anemia has a frequency similar to that of iron deficiency anemia Thus, we aimed to review the main aspects of health-disease-care process of maternal anemia, focusing on the comparison of maternal and iron deficiency anemia.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, there is no consensus that maternal anemia has a frequency similar to that of iron deficiency anemia Thus, we aimed to review the main aspects of health-disease-care process of maternal anemia, focusing on the comparison of maternal and iron deficiency anemia. Biological mechanisms, diagnostic criteria and prevalence were discussed [5][6][7][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Maternal Anemia and Iron Deficiency Anemia: Similarities and Singularities

Acmg¹,

Filho²,

Rb³

et al. 2018

Health Care Current Reviews

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Maternal anemia is a major global public health problem, and although widely discussed, there are few studies investigating the condition in pregnant women. In this article, issues related to the diagnosis, biological mechanism and prevalence of maternal anemia. In addition, iron deficiency anemia will be considered a proxy for maternal anemia. In previous studies, the concepts of maternal anemia have been controversial. It is also noted that isolated actions are not sufficient to combat this disease, and policies to address the primary causes of the associated nutritional deficiencies are necessary. Maternal Search strategiesMesh and similar terms were combined using Boolean operators (AND, OR), and the search strategy below was primarily used for Studies selectionAfter duplicate removal, titles and abstracts were screened for eligible articles independently by two reviewers (ACMGF and SSC). Two reviewers selected articles by reading titles and abstracts. During the process of selecting the articles the researchers were not aware of the decisions made by their colleague. After that, full text articles were assessed for eligibility. Discordant events were resolved by consensus. Data extractionData extraction was performed independently by two researchars (ACMGF and RBS) and discordant events resolved by consensus. We used a standardized electronic spreadsheet to extract the following information: author's name, year of publication, year of data collection and geographic region, study design, sample size, anemia diagnosis criteria, frequency of maternal anemia and iron deficiency anemia. Authors were contacted for additional information considered important for this review.

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Section: Is Iron Deficiency Anemia a Proxy For Maternal Anemia?mentioning

confidence: 99%

Section: Is Iron Deficiency Anemia a Proxy For Maternal Anemia?mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Maternal Anemia and Iron Deficiency Anemia: Similarities and Singularities

Acmg¹,

Filho²,

Rb³

et al. 2018

Health Care Current Reviews

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DUOX Defects and Their Roles in Congenital Hypothyroidism

Deken

Miot

2019

Methods in Molecular Biology

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Extracellular hydrogen peroxide is required for thyroperoxidase-mediated thyroid hormone synthesis in the follicular lumen of the thyroid gland. Among the NADPH oxidases, dual oxidases, DUOX1 and DUOX2, constitute a distinct subfamily initially identified as thyroid oxidases, based on their level of expression in the thyroid. Despite their high sequence similarity, the two isoforms present distinct regulations, tissue expression, and catalytic functions. Inactivating mutations in many of the genes involved in thyroid hormone synthesis cause thyroid dyshormonogenesis associated with iodide organification defect. This chapter provides an overview of the genetic alterations in DUOX2 and its maturation factor, DUOXA2, causing inherited severe hypothyroidism that clearly demonstrate the physiological implication of this oxidase in thyroid hormonogenesis. Mutations in the DUOX2 gene have been described in permanent but also in transient forms of congenital hypothyroidism. Moreover, accumulating evidence demonstrates that the high phenotypic variability associated with altered DUOX2 function is not directly related to the number of inactivated DUOX2 alleles, suggesting the existence of other pathophysiological factors. The presence of two DUOX isoforms and their corresponding maturation factors in the same organ could certainly constitute an efficient redundant mechanism to maintain sufficient H 2 O 2 supply for iodide organification. Many of the reported DUOX2 missense variants have not been functionally characterized, their clinical impact in the observed phenotype remaining unresolved, especially in mild transient congenital hypothyroidism. DUOX2 function should be carefully evaluated using an in vitro assay wherein (1) DUOXA2 is co-expressed, (2) H 2 O 2 production is activated, (3) and DUOX2 membrane expression is precisely analyzed.

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Anemia in Pregnancy

Pucci

Bernardes

2021

Perinatology

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Iron Status and Its Determinants in a Nationally Representative Sample of Pregnant Women

Cited by 32 publications

References 22 publications

Maternal Anemia and Iron Deficiency Anemia: Similarities and Singularities

Maternal Anemia and Iron Deficiency Anemia: Similarities and Singularities

DUOX Defects and Their Roles in Congenital Hypothyroidism

Anemia in Pregnancy

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