Iron Status and Neurobehavioral Development of Premature Infants

Armony-Sivan, Rinat; Eidelman, Arthur I.; Lanir, Amos; Sredni, Devora; Yehuda, Shlomo

doi:10.1038/sj.jp.7211178

Cited by 92 publications

(56 citation statements)

References 39 publications

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“…For instance, preterm infants with anemia and low ferritin had an increased number of abnormal reflexes evaluated according to the Assessment of Premature Infants Behavior at 37 weeks' postmenstrual age compared to nonanemic preterm infants [8]. …”

Section: Introductionmentioning

confidence: 99%

A Review of Cord Blood Concentrations of Iron Status Parameters to Define Reference Ranges for Preterm Infants

Lorenz¹,

Peter

Poets³

et al. 2013

Neonatology

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Background: Iron plays an essential role in various tissue functions, and hence the reliable assessment of iron nutrition status of preterm infants appears to be mandatory. Objectives: To summarize available data on cord blood concentrations of iron status parameters as surrogate reference ranges for preterm infants until term-equivalent age. Methods: Review of the literature searching PubMed for cord blood values of hemoglobin, mean corpuscular volume, ferritin, soluble transferrin receptor, ferritin index, transferrin saturation, reticulocyte hemoglobin content, zinc protoporphyrin/heme ratio, and hepcidin and comparison with reference ranges established for adults. Results: Gestational age-specific cord blood concentration ranges at term were computed as weighted mean for hemoglobin [15.9 g/dl (13.3-18.4)], mean corpuscular volume [108.1 fl (97.8-118.5)] and transferrin saturation [61.2% (31.5-90.9)] and listed for ferritin, soluble transferrin receptor, ferritin index, zinc protoporphyrin/heme ratio, reticulocyte hemoglobin content and hepcidin. These surrogate reference ranges were markedly different from adult values. Conclusion: Reference ranges of iron status parameters established for adults are probably not suitable to define iron status in preterm infants. If iron supplementation in preterm infants should be individually adjusted based on iron status parameters, it may be necessary to aim for cord blood concentration ranges to enable optimal growth and development.

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Section: Introductionmentioning

confidence: 99%

A Review of Cord Blood Concentrations of Iron Status Parameters to Define Reference Ranges for Preterm Infants

Lorenz¹,

Peter

Poets³

et al. 2013

Neonatology

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“…At present, there is no definitive cut-off that is indicative of suboptimal cord SF concentrations. In accordance with several studies that related cord SF to neurodevelopmental outcomes (37)(38)(39), for data analysis purposes, we used the same criteria of a cord SF concentration < 76 μg/l to define suboptimal SF concentrations at birth.…”

mentioning

confidence: 99%

Prevalence of anemia and associations between neonatal iron status, hepcidin, and maternal iron status among neonates born to pregnant adolescents

et al. 2015

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ArticlesBackground: Little is known about anemia and iron status in US newborns because screening for anemia is typically not undertaken until 1 y of age. This study was undertaken to characterize and identify determinants of iron status in newborns born to pregnant adolescents. Methods: Pregnant adolescents (≤ 18 y, n = 193) were followed from ≥ 12 wk gestation until delivery. Hemoglobin, ferritin, soluble transferrin receptor, serum iron, hepcidin, erythropoietin (EPO), IL-6, and C-reactive protein were assessed in maternal and cord blood. results: At birth, 21% of the neonates were anemic (Hb < 13.0 g/dl) and 25% had low iron stores (ferritin < 76 µg/l). Cord serum ferritin concentrations were not significantly associated with gestational age (GA) at birth across the range of 37-42 wk. Neonates born to mothers with ferritin < 12 µg/l had significantly lower ferritin (P = 0.003) compared to their counterparts. Hepcidin and IL-6 were significantly (P < 0.05) higher in neonates born to mothers with longer durations of active labor. conclusion: Given the importance of the iron stores at birth on maintenance of iron homeostasis over early infancy, additional screening of iron status at birth is warranted among those born to this high risk obstetric population.

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“…Recent studies have shown elevated zinc protoporphyrin/heme ratios in predischarge premature infants who are rapidly growing (59,60), suggesting that iron availability is limiting the ability of these infants to synthesize Hb. A recent study also demonstrates that preterm infants with ferritin concentrations in the lowest quartile at the end of their neo-natal intensive care unit hospitalization have an increased rate of abnormal neurologic reflexes (61). Although it remains to be determined whether these changes in brain function are long-lasting, this study is the first to link iron deficiency and abnormal neurodevelopment in this population.…”

Section: Iron and Brain Developmentmentioning

confidence: 87%

Controversial Nutrients That Potentially Affect Preterm Neurodevelopment: Essential Fatty Acids and Iron

2005

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Iron Status and Neurobehavioral Development of Premature Infants

Cited by 92 publications

References 39 publications

A Review of Cord Blood Concentrations of Iron Status Parameters to Define Reference Ranges for Preterm Infants

A Review of Cord Blood Concentrations of Iron Status Parameters to Define Reference Ranges for Preterm Infants

Prevalence of anemia and associations between neonatal iron status, hepcidin, and maternal iron status among neonates born to pregnant adolescents

Controversial Nutrients That Potentially Affect Preterm Neurodevelopment: Essential Fatty Acids and Iron

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