“…The successful production of AuNPs was corroborated by spectrophotometric measurements, evident in the SPR peak at 535 and 545 nm for Res-AuNPs and Res-GA-AuNPs, respectively. Similar SPR peaks were reported by Khoobchandani et al,44 Gamal-Eldeen et al,42 Geraldes et al,41 Pasanphan et al67 and Suganthy et al45 Moreover, the UV-vis spectra for the three-fold samples (3× Res-AuNPs and 3× Res-GA-AuNPs) show a 306 nm peak indicating increased trans-resveratrol coating onto the surface of AuNPs (Figure 3). Figure 3Ultraviolet–visible spectrum: ( A ) trans-resveratrol used in the reaction; ( B ) AuNPs in the absence of GA; and ( C ) AuNPs in the presence of GA.…”
Background:
As part of our continuing quest to enhance the efficacy of bioactive phytochemicals in cancer therapy, we report an innovative green nanotechnology approach toward the use of resveratrol for the production of biocompatible resveratrol-conjugated gold nanoparticles (Res-AuNPs). Our overarching aim is to exploit the inherent pro-apoptotic properties of gold nanoparticles (AuNPs) through synergistic anti-tumor characteristics of resveratrol, with the aim of developing a new class of green nanotechnology-based phytochemical-embedded AuNPs for applications in oncology.
Method:
Resveratrol was used to reduce Au
3+
to Au
0
for the synthesis of Res-AuNPs at room temperature and gum arabic (GA) was used to further encapsulate the nanoparticulate surface to increase the overall stability of the AuNPs. This comprehensive study involves the synthesis, full characterization and in vitro stability of Res-AuNPs in various biological media for their ultimate applications as anti-cancer agents against human breast (MDAMB-231), pancreatic (PANC-1) and prostate (PC-3) cancers.
Results:
This strategy to systematically increase the corona of resveratrol on AuNPs, in order to gain insights into the interrelationship of the phytochemical corona on the overall anti-tumor activities of Res-AuNPs, proved successful. The increased resveratrol corona on Res-AuNPs showed superior anti-cancer effects, attributed to an optimal cellular uptake after 24-hour incubation, while GA provided a protein matrix support for enhanced trans-resveratrol loading onto the surface of the AuNPs.
Conclusion:
The approach described in this study harnesses the benefits of nutraceuticals and nanoparticles toward the development of Res-AuNPs. We provide compelling evidence that the increased corona of resveratrol on AuNPs enhances the bioavailability of resveratrol so that therapeutically active species can be optimally available in vivo for applications in cancer therapy.
“…The successful production of AuNPs was corroborated by spectrophotometric measurements, evident in the SPR peak at 535 and 545 nm for Res-AuNPs and Res-GA-AuNPs, respectively. Similar SPR peaks were reported by Khoobchandani et al,44 Gamal-Eldeen et al,42 Geraldes et al,41 Pasanphan et al67 and Suganthy et al45 Moreover, the UV-vis spectra for the three-fold samples (3× Res-AuNPs and 3× Res-GA-AuNPs) show a 306 nm peak indicating increased trans-resveratrol coating onto the surface of AuNPs (Figure 3). Figure 3Ultraviolet–visible spectrum: ( A ) trans-resveratrol used in the reaction; ( B ) AuNPs in the absence of GA; and ( C ) AuNPs in the presence of GA.…”
Background:
As part of our continuing quest to enhance the efficacy of bioactive phytochemicals in cancer therapy, we report an innovative green nanotechnology approach toward the use of resveratrol for the production of biocompatible resveratrol-conjugated gold nanoparticles (Res-AuNPs). Our overarching aim is to exploit the inherent pro-apoptotic properties of gold nanoparticles (AuNPs) through synergistic anti-tumor characteristics of resveratrol, with the aim of developing a new class of green nanotechnology-based phytochemical-embedded AuNPs for applications in oncology.
Method:
Resveratrol was used to reduce Au
3+
to Au
0
for the synthesis of Res-AuNPs at room temperature and gum arabic (GA) was used to further encapsulate the nanoparticulate surface to increase the overall stability of the AuNPs. This comprehensive study involves the synthesis, full characterization and in vitro stability of Res-AuNPs in various biological media for their ultimate applications as anti-cancer agents against human breast (MDAMB-231), pancreatic (PANC-1) and prostate (PC-3) cancers.
Results:
This strategy to systematically increase the corona of resveratrol on AuNPs, in order to gain insights into the interrelationship of the phytochemical corona on the overall anti-tumor activities of Res-AuNPs, proved successful. The increased resveratrol corona on Res-AuNPs showed superior anti-cancer effects, attributed to an optimal cellular uptake after 24-hour incubation, while GA provided a protein matrix support for enhanced trans-resveratrol loading onto the surface of the AuNPs.
Conclusion:
The approach described in this study harnesses the benefits of nutraceuticals and nanoparticles toward the development of Res-AuNPs. We provide compelling evidence that the increased corona of resveratrol on AuNPs enhances the bioavailability of resveratrol so that therapeutically active species can be optimally available in vivo for applications in cancer therapy.
“…Besides, in the post-processing of organic solvents, it is difficult to avoid the environmental pollution. Therefore, eco-friendly, handy, and efficient synthesis strategy on the use of non-organic solvents or nonsolvent has become the chief target and mission of chemists [27][28][29].…”
In this study, a group of novel water soluble chitosan ammonium salts with halogens were successfully synthesized, including chitosan-bromoacetate (CSB), chitosan-chloroacetate (CSC), chitosan-dichloroacetate (CSDC), chitosan-trichloroacetate (CSTC), and chitosan-trifluoroacetate (CSTF), and their antifungal activities against three kinds of phytopathogens were comparatively estimated by hypha measurement in vitro, respectively. The fungicidal assessment revealed that the synthesized chitosan derivatives had higher antifungal activity than chitosan. Especially, the inhibitory indices of CSTC and CSTF against three kinds of phytopathogens were higher than 70% at 1.0mg/mL. Generally, the antifungal activity decreased in the order: CSTF>CSTC>CSDC>CSC>CSB>chitosan. Apparently, the order of antifungal activity was consistent with the electronegativity of different substituted groups with halogens. The substituted groups with stronger electronegativity could augment the positive charge densities of cationic amino groups by drawing more electrons from the cationic amino groups of chitosan ammonium salts, which demonstrated that the protonation of amino groups was significant for the antifungal activity of chitosan derivatives.
“…The current applications of ionizing radiation and their connection with nanotechnology represent a research area that has gained special attention in recent years [1][2][3][4]. The revolutionary development of science and engineering has enabled the synthesis of nano-sized materials in order to take advantage of their unique properties that differ significantly from those of the individual atoms [5,6].…”
Radiochemical synthesis of metallic nanoparticles is an eco-friendly method allowing the obtaining of controlled size, well dispersed and highly stable particles at very mild conditions. Colloidal silver nanoparticles were synthesized in a one-step process, in an aqueous system consisting of polyvinyl alcohol (PVA)/Ag+/isopropyl alcohol (IPA), irradiated at various doses by using high energy ionizing radiations (g-rays). The UV-Vis spectra have shown a maximum absorption peak in the range of 390-450 nm, specific for silver nanoparticles. The size of the obtained spherical shape nanoparticles was below 50 nm and decreased with increasing of the irradiation dose.
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