Irradiation-Induced Crosslinking of Collagen

Bailey, Allen J.; Rhodes, D. N.; Cater, C. W.

doi:10.2307/3571543

Cited by 98 publications

(47 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mateles (1957) and Bailey et al (1964) suggest that lack of chain mobility of gelatin molecules in the dry state prevents cross-linking of free radicals of polypeptide formed by radiation-induced scission of protein molecules ; consequently, degradation of proteins takes place during irradiation in the dry state. However, high water contents may favor recombination of polypeptide radicals with the possibility that crosslinking predominates over oxidative scission.…”

Section: Resultsmentioning

confidence: 98%

Oxidation Effects in a Freeze‐Dried Gelatin‐Methyl Linoleate System

Zirlin

Karel

1969

Journal of Food Science

View full text Add to dashboard Cite

SUMMARY– We studied oxidation of a freeze‐dried model system consisting of methyl linoleate and gelatin by incubating the model system in air at 50°C for up to 10 days in the dry state or at controlled relative humidities. Incubation for 5‐10 days caused a drop in the viscosity of gelatin solutions, an increase in the solubility of gelatin in ethanol‐rich solvent mixtures, an increase in the retention time of gelatin on a Sephadex G‐150 column, and a reduction in the melting point of a standard gelatin gel. There were no such changes in the viscosity and solubility properties of gelatin when incubation was at a relative humidity of approximately 60%. In some instances, incubation at high relative humidity led to partial insolubilization of gelatin in water or in acetate buffer. The oxidation effects in the dry state were consistent with the hypothesis that gelatin undergoes oxidative degradation. The effects of oxidation showed similarities to effects of ionizing radiations.

show abstract

Section: Resultsmentioning

confidence: 98%

Oxidation Effects in a Freeze‐Dried Gelatin‐Methyl Linoleate System

Zirlin

Karel

1969

Journal of Food Science

View full text Add to dashboard Cite

show abstract

“…[5][6][7] Micrometer-sized air-filled or liquid-filled proteinaceous microspheres (PMs) were synthesized from various kinds of proteins, such as bovine serum albumin (BSA), [8][9][10] human serum albumin (HAS), [11] and hemoglobin (Hb) [12] by the sonochemical method developed by Suslick and co-workers. In the late 1960s, a modified polymerization method for the preparation of proteinaceous microspheres was developed by Rhodes, Scheffel, Wagner, and Zolle et al [13][14][15] The microsphere formation was accomplished by either heat denaturation at various temperatures or by cross-linking with carbonyl compounds in the ether phase. Other cross-linking agents, such as glutaraldehyde, were also used.…”

Section: Introductionmentioning

confidence: 99%

Microspheres of Mixed Proteins

Angel

Matas

Michaeli

et al. 2010

Chemistry A European J

View full text Add to dashboard Cite

This paper describes the synthesis of mixed proteinaceous microspheres (MPMs) by the sonochemical method. The current fundamental research follows the research of Suslick and co-workers who have developed a method by which high-intensity ultrasound is used to make aqueous suspensions of proteinaceous microcapsules filled with water-insoluble liquids.1 By using high-intensity ultrasound, we have synthesized microspheres made of a few different proteins. The three proteins used in the current experiments are bovine serum albumin (BSA), green fluorescent protein (GFP), and cyan fluorescent protein-glucose binding protein-yellow fluorescent fused protein (CFP-GBP-YFP). The two synthesized microspheres made of mixed proteins are BSA-GFP and BSA-(CFP-GBP-YFP). This paper presents the characterization of the sonochemically produced microspheres of mixed proteins. It also provides an estimate of the efficiency of the sonochemical process in converting the native proteins to microspheres.

show abstract

“…5 GISC remains transparent, owing to the crosslinking process, when irradiated with gamma rays. 25,26 Three cases in the current cohort underwent laser suture lysis after ADD Irradiated cornea in aqueous drainage device surgery Q Pan et al surgery, demonstrating the merit of maintained transparency in GISC tissues. This property provides not only a cosmetic benefit to patients but also makes it easier for surgeons to monitor the underlying tube (Figure 1d).…”

Section: Discussionmentioning

confidence: 75%

Clinical outcomes of gamma-irradiated sterile cornea in aqueous drainage device surgery: a multicenter retrospective study

Pan

Jampel

Ramulu

et al. 2016

Eye

View full text Add to dashboard Cite

Purpose The purpose of the study was to evaluate the safety and efficacy of gammairradiated sterile cornea (GISC) for covering the tube in aqueous drainage device (ADD) surgery in a retrospective, multicenter case series. Patients and methods Participants included 297 patients (321 procedures) who had undergone ADD surgery for the first time using GISC patch at three clinic centers in the United States between April 2009 and July 2012. The medical records of those consecutive patients were reviewed. Preoperative, intraoperative, and postoperative parameters about GISC were collected and analyzed. The main outcome measures were patch graft failure (PGF) and postoperative complications related to GISC. Results Three hundred and nineteen eyes in 295 patients were included in the current analysis. Ten out of the 319 eyes experienced PGF with a mean follow-up of 15.4 ± 9.8 (SD) months. The overall cumulative PGF proportion from KaplanMeier analysis was 2.6% (95% CI: 0.6-4.7%) at 18 months. We detected two cases of presumed endophthalmitis related to PGF. Conclusions GISC appears to have a reasonable success rate for preventing tube exposure related to PGF over an 18-month period. This success rate, in combination with other features of GISC (transparency and storage at room temperature), makes it a viable choice for patch graft material during ADD.

show abstract

Irradiation-Induced Crosslinking of Collagen

Cited by 98 publications

References 17 publications

Oxidation Effects in a Freeze‐Dried Gelatin‐Methyl Linoleate System

Oxidation Effects in a Freeze‐Dried Gelatin‐Methyl Linoleate System

Microspheres of Mixed Proteins

Clinical outcomes of gamma-irradiated sterile cornea in aqueous drainage device surgery: a multicenter retrospective study

Contact Info

Product

Resources

About