Irradiation of glomus jugulare tumors: a historical perspective

Li, Gordon; Chang, Steven D.; Adler, John R.; Lim, Michael

doi:10.3171/foc-07/12/e13

Cited by 34 publications

(33 citation statements)

References 21 publications

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“…The second aspect is that the consequences of injury to the low cranial nerves, which are typically involved in GJT, are very severe. [22]…”

Section: Discussionmentioning

confidence: 99%

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Stereotactic radiosurgery for the treatment of Glomus Jugulare Tumors

Andrade¹,

Brito²,

Mario³

et al. 2013

Surg Neurol Int

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Background:The glomus jugulare tumor is a slowly growing benign neoplasm originating from neural crest. There is a high morbidity associated with surgical resection of glomus jugulare. Radiosurgery play a relevant role as a therapeutic option in these tumors and its use has grown in popularity. The authors describe a retrospective series of 15 patients and reviewed the literature about the glomus jugulare tumors.Methods:We reviewed retrospectively the data of 15 patients treated with stereotactic linear accelerator stereotactic radiosurgery (LINAC) radiosurgery between 2006 and 2011.Results:The average tumor volume was 18.5 cm3. The radiation dose to the tumor margin ranged between 12 and 20 Gy. The neurological status improved in three patients and remained unchanged in 12 patients. One patient developed a transient 7th nerve palsy that improved after clinical treatment. All tumors remained stable in size on follow-up with resonance magnetic images.Conclusions:The radiosurgery is a safe and effective therapy for patients with glomus jugulare tumor. Despite the short follow-up period and the limited number of patients analyzed, we can infer that radiosurgery produce a tumor growth control with low morbidity, and may be used as a good option to surgical resection in selected cases.

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“…The second aspect is that the consequences of injury to the low cranial nerves, which are typically involved in GJT, are very severe. [22]…”

Section: Discussionmentioning

confidence: 99%

“…[119223340] In tumors with intracranial extension the rate of postoperative cranial nerve palsy ranges between 22% and 100%. [19202639] Mortality is significant, and can oscillate between 4.2% and 6.4% according to some studies.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic radiosurgery for the treatment of Glomus Jugulare Tumors

Andrade¹,

Brito²,

Mario³

et al. 2013

Surg Neurol Int

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“…Embolization is not considered curative due to formation of anastomotic blood vessels and is recommended only as a preparation for surgery. 16 Meanwhile, external-beam radiotherapy presents the risk of serious complications due to large fields size, as suggested by Li et al 17 Gamma Knife surgery emerged as an alternative during the last decade due to its minimal invasiveness and local tumor control rates comparable to surgical strategies, while preserving or even improving cranial nerve function. [4][5][6]18 Recently it has been reported that functioning PGLs also respond to stereotactic radiosurgery, and in particular to GKS, at both the biochemical and neuroradiological level.…”

Section: Surgical Intervention and Initial Surveillancementioning

confidence: 99%

Clinical and biochemical responses after Gamma Knife surgery for a dopamine-secreting paraganglioma: case report

Tuleasca

Jaquet

Schweizer

et al. 2015

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IntRoductIon: the efficacy of Gamma Knife surgery (GKs) in local tumor control of non-secreting paragangliomas (PGLs) has been fully described by previous studies. However, with regard to secreting PGL, only one previous case report exists advocating its efficacy at a biological level. cAse RePoRt: the aims of this study were: 1) to evaluate the safety/efficacy of GKs in a dopamine-secreting PGL; 2) to investigate whether the biological concentrations of free methoxytyramine could be used as a marker of treatment efficacy during the follow-up. we describe the case of a 62-year-old man diagnosed with left PGL. He initially underwent complete surgical excision. thirty months after, he developed recurrent biological and neuroradiological disease; the most sensitive biomarker for monitoring the disease, concentration of plasma free methoxytyramine, started to increase. GKs was performed at a maximal marginal dose of 16 Gy. during the following 30 months, concentration of free methoxytyramine gradually decreased from 0.14 nmol/l (2*uRL) before GKs to 0.09 nmol/l, 6 months after GKs and 0.07 nmol/l at the last follow-up after GKs (1.1*uRL), confirming the efficacy of the treatment. Additionally, at 30 months there was approximately 36.6% shrinkage from the initial target volume. concLusIon: the GKs treatment was safe and effective, this being confirmed clinically, neuroradiologically and biologically. the case illustrates the importance of laboratory tests taking into account methoxytyramine when analyzing biological samples to assess the biochemical activity of a PGL. In addition, the identification of methoxytyramine as a unique positive biomarker could designate it for the monitoring of tumor relapse after treatments, including Gamma Knife surgery.

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“…Anderson Cancer Center from 1944 to 1964 consisted of administering 45 Gy to the tumor bed over 35 days. 32 It is important to note that the majority of patients included in these initial reports received radiation therapy following subtotal resection, and that radiation was not considered primary therapy outside of palliation for neoplasms believed to be inoperable. Despite its restricted use, these preliminary forms of radiotherapy were believed to be relatively effective; a meta-analysis of treatments performed prior to 1981 reported acceptable local control in 91% of patients, with low rates of morbidity.…”

Section: Evolution In Tumor Managementmentioning

confidence: 99%