Irradiation of the Intestine by Radioisotopes

Sullivan, M.F.; Hackett, P.L.; George, L. A.; Thompson, Roy C.

doi:10.2307/3570967

Cited by 13 publications

(4 citation statements)

References 8 publications

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“…Exposure to 3.3 x 10s pCi/kg resulted in 45% mortalit.yand growth inhibition in the survivors(Fritsch et al 1987).Histological changes were observed in the large intestine of adult rats given 160 mCi plutonium-239 dioxide/kg body weight. However, the changes were resolved by 6 days post-exposure(Sullivan et al 1960). Histological changes in the gastrointestinaltract (e.g., hypertrophyof the crypts of the small intestine) of neonatalrats were producedwhen the rats were exposed to 1.0 x 105 pCi plutonium-239 dioxide/kg body weight.…”

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confidence: 99%

Ecotoxicity literature review of selected Hanford Site contaminants

Driver¹

1994

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Printedin the United Slatesof America Availableto DOE andDOE contractorsfrom the Office of ScientificandTechnicalInformation,P.O. Box62, Oak Ridge,TN 37831; pricesavailablefrom (615) 576-8401. FTS626-8401. Availableto the publicfrom the National TechnicalInformationService, U.S. Departmentof Commerce,5285 Port RoyalRd., Springfield,VA 22161._The contents of this report were printed on recycled paper

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confidence: 99%

Ecotoxicity literature review of selected Hanford Site contaminants

Driver¹

1994

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“…Comparative experiments with radiation of dayerent penetrating powers SULLIVAN et al (72) gave rats 155 mclkg of plutonium-239 by mouth and showed that there was no significant acute histological damage. This dose of plutonium was calculated to give 100,000 rad to the surface of the mucosa of the small intestine.…”

Section: Distance From Gi-tract Contents To Mitosing Cellsmentioning

confidence: 98%

A Review of the Physiology of the Gastrointestinal Tract in Relation to Radiation Doses from Radioactive Materials

Is¹

1966

Health Physics

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“…Plutonium a-particles induced only mild and superficial lesions confined to the cecum and colon. The authors concluded that ingested a-emitters did not induce acute toxicity, in contrast to g-emitters, because of the poor penetration of a-irradiation to the radiosensitive crypt cells (78). In contrast, in neonatal rats, acute intestinal lesions leading to death were observed after gavage of 238Pu (IV)-citrate (122 kBq per animal) (79).…”

Section: Effects Of Nuclear Fuel Compounds On the Gastrointestinal Tractmentioning

confidence: 99%

Biokinetics of nuclear fuel compounds and biological effects of nonuniform radiation.

Lang

Servomaa

Kosma

et al. 1995

Environ Health Perspect

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Environmental releases of insoluble nuclear fuel compounds may occur at nuclear power plants during normal operation, after nuclear power plant accidents, and as a consequence of nuclear weapons testing. For example, the Chernobyl fallout contained extensive amounts of pulverized nuclear fuel composed of uranium and its nonvolatile fission products. The effects of these highly radioactive particles, also called hot particles, on humans are not well known due to lack of reliable data on the extent of the exposure. However, the biokinetics and biological effects of nuclear fuel compounds have been investigated in a number of experimental studies using various cellular systems and laboratory animals. In this article, we review the biokinetic properties and effects of insoluble nuclear fuel compounds, with special reference to UO2, PuO2, and nonvolatile, long-lived beta-emitters Zr, Nb, Ru, and Ce. First, the data on hot particles, including sources, dosimetry, and human exposure are discussed. Second, the biokinetics of insoluble nuclear fuel compounds in the gastrointestinal tract and respiratory tract are reviewed. Finally, short- and long-term biological effects of nonuniform alpha- and beta-irradiation on the gastrointestinal tract, lungs, and skin are discussed.Imagesp920-aFigure 1.

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Irradiation of the Intestine by Radioisotopes

Cited by 13 publications

References 8 publications

Ecotoxicity literature review of selected Hanford Site contaminants

Ecotoxicity literature review of selected Hanford Site contaminants

A Review of the Physiology of the Gastrointestinal Tract in Relation to Radiation Doses from Radioactive Materials

Biokinetics of nuclear fuel compounds and biological effects of nonuniform radiation.

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