Irradiation of the tumor bed alone after lumpectomy in selected patients with early-stage breast cancer treated with breast conserving therapy

Vicini, Frank A.; Kini, Vijay R.; Chen, Peter; Horwitz, Eric M.; Gustafson, Gary; Benitez, Pamela; Edmundson, Greg; Goldstein, Neal S.; McCarthy, Kevin; Martínez, Álvaro

doi:10.1002/(sici)1096-9098(199901)70:1<33::aid-jso6>3.0.co;2-o

Cited by 102 publications

(21 citation statements)

References 46 publications

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“…Multiple studies report that the doses given in adjuvant RT are similar in magnitude to the doses given to mastectomy patients (45-50 Gy to the entire breast with or without an additional 20 -25 Gy to the tumor bed), but absorbed doses are much lower due to the physical barrier of the remaining breast tissue and new megavoltage treatments. 26,27 Among the atomic bomb survivors, 5 the excess relative rate (ERR) coefficient for women was higher for those with adenocarcinoma and squamous cell carcinoma than for those with small cell carcinoma. In addition, adenocarcinoma was the most common type of lung carcinoma and displayed a clear doseresponse relation.…”

Section: Discussionmentioning

confidence: 99%

Lung carcinoma after radiation therapy in women treated with lumpectomy or mastectomy for primary breast carcinoma

Zablotska

Neugut

2003

Cancer

130

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BACKGROUNDPrior studies have demonstrated that women who receive adjuvant radiation therapy (RT) after mastectomy for breast carcinoma have an increased risk of a second primary lung carcinoma after 10 years, but, to the authors' knowledge, the risk associated with adjuvant RT after breast‐conserving surgery (lumpectomy) has yet to be determined. The purpose of the current study was to confirm and extend earlier findings of the effects of postmastectomy RT on second primary lung carcinoma and to investigate the impact of postlumpectomy RT on second primary lung carcinoma in the same population and to compare the results.METHODSThe authors used data from the population‐based Surveillance, Epidemiology, and End Results (SEER) program of the U.S. National Cancer Institute, encompassing approximately 10% of the U.S. population, from 1973 to 1998. Of the women with nonmetastatic invasive breast carcinoma, 194,981 had been treated with mastectomy and 65,560 were treated with lumpectomy. Cox regression analysis was used to estimate the relative risk (RR) of a second primary lung carcinoma among women treated with RT compared with those who received surgery alone as a function of time interval since treatment and laterality for both types of surgery.RESULTSAlthough no statistically significant elevation in risk for second primary lung carcinoma prior to 10 years was observed, the authors estimated a RR of 2.06 (95% confidence interval [95% CI], 1.53–2.78) and 2.09 (95% CI, 1.50–2.90) for ipsilateral lung carcinoma at 10–14 years and 15+ years after postmastectomy RT, respectively, whereas no increased risk was observed for the contralateral lung. The excess risk of ipsilateral lung carcinoma after postmastectomy RT was found for all three major histologic subtypes of lung carcinoma (adenocarcinoma, squamous cell carcinoma, and small cell carcinoma). No increased risk of lung carcinoma was observed at 10–14 years after postlumpectomy RT for either lung.CONCLUSIONSPostmastectomy RT was found to provide a moderate increase in risk for ipsilateral lung carcinoma starting 10 years after exposure; this increased risk is reported to persist to at least 20 years. Postlumpectomy RT does not appear to incur an increased risk. These findings should be reassuring to women treated with either type of RT, but the excess risk in the postmastectomy group should be considered in the choice between treatment options. Cancer 2003;97:1404–11. © 2003 American Cancer Society.DOI 10.1002/cncr.11214

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Section: Discussionmentioning

confidence: 99%

Lung carcinoma after radiation therapy in women treated with lumpectomy or mastectomy for primary breast carcinoma

Zablotska

Neugut

2003

Cancer

130

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“…Several groups have explored in phase I and II studies the use of brachytherapy to treat less than the entire breast tissue (39)(40)(41)(42). An external-beam approach is more likely to (a) be more acceptable to the patient, (b) be more widely reproducible, and (c) generate better dose homogeneity and cosmetic results than brachytherapy (43,44).…”

Section: Discussionmentioning

confidence: 99%

Hypo-Fractionated Conformal Radiation Therapy to the Tumor Bed After Segmental Mastectomy

Formenti¹

2005

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“…Contrast media for localization was placed in the cavity during the time of fiducial placement. Using similar technique to Vicini [6] . The patients was positioned supine in a stereotactic Electa Steriotactic Body Frame (SBR) body frame utilizing a diaphragmatic plunger to reduce/control breathing variances and, to some degree, immobilize the breast itself.…”

Section: Methodsmentioning

confidence: 99%

A QA Analysis of a Contrast Localized Linac-Based Technique for Hypo-Fractionated Partial Breast Radiotherapy

Dillon

Woodburn²,

Kulig³

2015

International Journal of Radiology

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Irradiation of the tumor bed alone after lumpectomy in selected patients with early-stage breast cancer treated with breast conserving therapy

Cited by 102 publications

References 46 publications

Lung carcinoma after radiation therapy in women treated with lumpectomy or mastectomy for primary breast carcinoma

Lung carcinoma after radiation therapy in women treated with lumpectomy or mastectomy for primary breast carcinoma

Hypo-Fractionated Conformal Radiation Therapy to the Tumor Bed After Segmental Mastectomy

A QA Analysis of a Contrast Localized Linac-Based Technique for Hypo-Fractionated Partial Breast Radiotherapy

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