Irradiation Treatment of Carcinoma of the Prostate: A Preliminary Report Based on 8 Years of Experience

Iodine-125-Seed Implantation Combined with External Radiotherapy under Potentially Curative Intention in Patients with Advanced Stage-C Prostatic Cancer

“…Since that time a number of reports have described various methods of interstitial and/or external beam irradiation [1][2][3][4][8][9][10][11][12][13][14][15]. The value of retropubic implantation of the prostate with l25I and simultaneous pelvic lymphadenectomy as mode of therapy for localized prostatic carcinoma has been explored by Whitmore et al [15].…”

The Role of Radiation Therapy in the Definitive Treatment of Adenocarcinoma of the Prostate

“…Unfortunately, clinical staging was not reported, a large proportion of the entire group had some form of hormonal manipulation, and we are not told the exact number of patients followed for 5 and 10 yr among the subgroup of 47 patients. Carlton et al (32) reported the results of treatment in 106 patients treated with curative intent. These patients received a total dose to the prostate of 6000 -7500 rads delivered by a combination of interstitial irradiation using radioactive gold seeds followed by external irradiation.…”

“…However, reservations as to the validity of our criteria for local control may be raised by the recent description by other investiga tors of persistent carcinoma in biopsies of the prostate, some of normal consistency, months to years following irradiation (32,38). A recent report by Cox & Tijerina (39) presented preliminary results of 68 transperineal prostatic biopsies obtained from 30 patients 3-30 months after completion of radiation therapy.…”

Long-Term Outcomes of Alternative Brachytherapy Techniques for Early Prostate Cancer

“…Although early experience with brachytherapy using freehand placement of radioactive seeds in open pelvic surgery yielded both unsatisfactory control of cancer and high post-treatment complication rates (15)(16)(17)(18), a percutaneous ultrasound-guided technique developed by Blasko, Ragde and colleagues in Seattle dramatically improved three-dimensional radiation dose distributions (13)(14)(15). As a result, brachytherapy was reevaluated (7), resulting in its now wide availability in the United States (19).…”