The physical phenomena of convective flow of Cross fluid containing carboxymethyl cellulose water over a stretching sheet with convective heating were studied. Cross nanofluid containing
A
l
2
O
3
,
Cu
nanoparticles, and based fluid of CMC water is used. Entropy generation minimization is examined in the current analysis. The system of PDEs is altered into a set of ODEs through suitable conversion. Further, these equations are computed numerically through the MATLAB BVP4c technique. The behavior of governing parameters on the velocity, temperature, entropy generation, and Bejan number is plotted and reported via graphs. It is found that the larger value of unsteady variable reduced the velocity, thermal layer, and entropy production. Surface drag frication of the
A
l
2
O
3
and
Cu
and
A
l
2
O
3
+
Cu
is enhanced with the more presence of unsteady parameter. Comparison of current results in a limiting case is obtained with earlier analysis and found an optimum agreement.