2013
DOI: 10.1371/journal.pone.0076260
|View full text |Cite
|
Sign up to set email alerts
|

Irreversible Electroporation Ablation (IRE) of Unresectable Soft Tissue Tumors: Learning Curve Evaluation in the First 150 Patients Treated

Abstract: BackgroundIrreversible electroporation (IRE) is a novel technology that uses peri-target discrete probes to deliver high-voltage localized electric current to induce cell death without thermal-induced coagulative necrosis. “Learnability” and consistently effective results by novice practitioners is essential for determining acceptance of novel techniques. This multi-center prospectively-collected database study evaluates the learning curve of IRE.MethodsAnalysis of 150 consecutive patients over 7 institutions … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
92
0
1

Year Published

2015
2015
2023
2023

Publication Types

Select...
10

Relationship

3
7

Authors

Journals

citations
Cited by 115 publications
(93 citation statements)
references
References 18 publications
0
92
0
1
Order By: Relevance
“…The requirements to place these multiple monopolar probes in precise spacing (plus or minus 5.0 mm maximum), precise depth (plus or minus 5.0 mm maximum), and in appropriate bracketing of the soft tissue retroperitoneal tumor that is commonly seen with pancreatic adenocarcinoma can be difficult. There is an essential learning curve, 36 and the optimal access for the placement of these devices for both pancreatic head tumors 6 and pancreatic neck tumors 15 has been published and is currently reproducible. Additional research into the optimal efficacy endpoints and validation that the use of IRE is performed via a nonthermal injury technique have also been validated and confirmed, which is essential to the safe and efficacious use of IRE around LAPC.…”
Section: Discussionmentioning
confidence: 99%
“…The requirements to place these multiple monopolar probes in precise spacing (plus or minus 5.0 mm maximum), precise depth (plus or minus 5.0 mm maximum), and in appropriate bracketing of the soft tissue retroperitoneal tumor that is commonly seen with pancreatic adenocarcinoma can be difficult. There is an essential learning curve, 36 and the optimal access for the placement of these devices for both pancreatic head tumors 6 and pancreatic neck tumors 15 has been published and is currently reproducible. Additional research into the optimal efficacy endpoints and validation that the use of IRE is performed via a nonthermal injury technique have also been validated and confirmed, which is essential to the safe and efficacious use of IRE around LAPC.…”
Section: Discussionmentioning
confidence: 99%
“…Given that, during IRE in contrast with radiofrequency ablation (RFA), microwave ablation or conventional electric heating, the thermal effect of electric current is not applied, and the ablation result is not negatively affected by a possible cooling of the blood flowing in the vessels running near the electrodes (the heat sink effect). At the same time, there should be no damage to the ligament structures of blood vessels, nerves, ducts, bronchi or ureters (Maor et al 2007;Philips et al 2013;, (see Table 3). This ablation technique is used in human medicine for the treatment of primary and secondary tumours of the liver, kidney, lung, prostate, pancreas, eyes, and brain.…”
Section: Discussionmentioning
confidence: 99%
“…However, only 19% were related to the procedure itself and with incomplete ablation in 2 cases. Another important point demonstrated in this study is the correlation of the learning curve to the rate of complications, which seems to drop after a cumulative experience of minimal 5 IRE cases in PC [56]. …”
Section: Ablation Therapy For Lapcmentioning
confidence: 99%