Irreversible inhibition of phosphotransacetylase by S-dimethylarsino-CoA

Duhr, Edward F.; Owens, Martha S.; Barden, Roland E.

doi:10.1016/0167-4838(83)90154-1

Search citation statements

Order By: Relevance

Paper Sections

Select...

E Other Thiol-modified Coa Derivatives2

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1988

2000

Publication Types

Select...

Book4

Article2

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 6 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S -Dimethylarsino-CoA (CoAS−As(CH 3 ) 2 ) was prepared by reaction of CoA with dimethylchloroarsine . This compound was shown to irreversibly inactivate phosphotransacetylase, apparently by transfer of the dimethylarsine group to a cysteine thiol group of the enzyme.…”

Section: E Other Thiol-modified Coa Derivativesmentioning

confidence: 99%

“…S-Dimethylarsino-CoA (CoAS-As(CH 3 ) 2 ) was prepared by reaction of CoA with dimethylchloroarsine. 235 This compound was shown to irreversibly inactivate phosphotransacetylase, apparently by transfer of the dimethylarsine group to a cysteine thiol group of the enzyme. This compound did not inactivate carnitine acetyltransferase or citrate synthase but was a reversible inhibitor of both enzymes, with K i values near the K m for acetyl-CoA.…”

Section: E Other Thiol-modified Coa Derivativesmentioning

confidence: 99%

See 1 more Smart Citation