2006
DOI: 10.1016/j.lfs.2006.02.022
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Irreversible morphological changes in leg bone following chronic gravitational unloading of growing rats

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Cited by 20 publications
(25 citation statements)
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“…However, no tension was detected and the electromyogram activity was reduced ϳ88% when the ankle joints were stretched during hindlimb unloading because of the passive shortening of muscle fibers and sarcomeres. The electromyogram activity was also inhibited in soleus muscle during unloading in the present study (29). Thus, it is clear that both electrical and mechanical activities of soleus were inhibited during the longterm unloading.…”
Section: Discussionsupporting
confidence: 71%
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“…However, no tension was detected and the electromyogram activity was reduced ϳ88% when the ankle joints were stretched during hindlimb unloading because of the passive shortening of muscle fibers and sarcomeres. The electromyogram activity was also inhibited in soleus muscle during unloading in the present study (29). Thus, it is clear that both electrical and mechanical activities of soleus were inhibited during the longterm unloading.…”
Section: Discussionsupporting
confidence: 71%
“…Thus, it is suggested that mechanical and/or neuronal activities may not play an essential role in muscle fiber formation during postnatal development. The data obtained in the current study also suggest that muscle fiber formation or fiber number in soleus muscle may be genetically programmed or influenced by passive stretch due to the longitudinal growth of bone (29), as is also stated below. Stretching of muscle fibers generally causes hypertrophy and/or increase in protein content (13,38).…”
Section: Fiber Numbersupporting
confidence: 78%
“…3). The EMG activities in both the soleus (~86%) and plantaris (90%) muscles were decreased in response to hindlimb suspension, relative to those during rest on the f loor [5,19]. However, the magnitude of hindlimb suspension induced by reduction in the absolute EMG activity in the plantaris muscle (~90 mV/h) was minor relative to that in the soleus muscle (~473 mV/h).…”
Section: Discussionmentioning
confidence: 99%
“…It is suggested that the decreased mRNA expression levels of these HSPs in the slow-twitch day in a slow-twitch soleus neuromuscular unit, but only 3,000 impulses are generated per day in a fast-twitch tibialis anterior neuromuscular unit [18]. Similarly, EMG activities (~550 mV/h) of the soleus muscle in rats at rest are approximately 5 times greater than those (~100 mV/h) of the plantaris muscle [5,19].…”
Section: Spacefl Ightmentioning
confidence: 99%
“…With disuse, the skeleton seems to recognize that not all of its bone mass is needed to maintain structural integrity; bone mass decreases as a result of mineral density reduction (11), the bone architectural structure deteriorates, and osteopenia results. Weakening of the bone may lead to fractures or other musculoskeletal damage when physical activities are resumed (12,13).…”
Section: Introductionmentioning
confidence: 99%