Human activities, such as human water use, have been shown to directly influence terrestrial water fluxes and states. Simulations of soil moisture, river discharge, evapotranspiration, and groundwater storage are significantly improved, if human interactions, such as irrigation and groundwater abstraction, are incorporated. Yet improvements through the incorporation of human water use on the simulation of local and remote precipitation are rarely studied but may contribute to the skill of land surface fluxes. In this study, we evaluate the impact of human water use on the skill of evapotranspiration and precipitation in a fully coupled bedrock-to-atmosphere modeling platform. The results show that human water use can potentially increase the skill of the simulations across scales. However, observational uncertainty at the watershed scale limits the identification of model deficiencies and added value related to human water use. Locally, daily precipitation statistics potentially benefit from the incorporation of human water use. Although the incorporation of human water use does not remove the wet bias, it can increase the model skill.Plain Language Summary Precipitation forecasts exhibit large uncertainties, arising from unknown initial conditions and states, and limitations of models to represent processes at various scales. In order to improve simulations of the terrestrial water cycle, studies seek to improve the realism of the applied models through, for example, increased spatial resolution or the incorporation of additional processes across the Earth system. Here we analyze how the incorporation of additional processes in a European modeling system affects the accuracy of the simulated water fluxes, that is, evapotranspiration and precipitation. In particular, we improve the representation of groundwater in a continental-scale, atmospheric model and include groundwater pumping and irrigation, as major components of human water use. Results indicate that large-scale averages of precipitation, for example, over watersheds, are not necessarily improved if human water use is considered. However, significance of this finding is difficult to establish, because observational data sets exhibit large uncertainties, arising from, for example, the lack of observations in space and time, and miscalibration of the measuring devices. However, our results indicate that the accuracy of simulated daily precipitation is locally improved, which suggests that the incorporation of human water use may increase the accuracy of precipitation forecasts and advance our understanding of water cycle processes.