Irritability in Huntington's Disease: Factor Analysis of Snaith's Irritability Scale

Maltby, John; Dale, Maria; Underwood, Mandy; Simpson, Jane

doi:10.1002/mdc3.12424

Cited by 6 publications

(1 citation statement)

References 46 publications

(88 reference statements)

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“…1 Core and extended battery datasets are collected annually 2 from research participants as part of this multicenter longitudinal observational study [17]. We obtained the following data: age; sex; pharmacotherapy; CAG repeat length; Unified Huntington Disease Rating Scale (UHDRS), which includes Total Functional Capacity (TFC), Total Motor Score (TMS), Functional Assessment (FA), and Independence Scale (IS) [20]; Symbol Digital Modality Test (SDMT) [21]; Short Problem Behavior Assessment (PBA-s) [22]; Hospital Anxiety and Depression Scale combined with the Snaith Irritability Scale (HADS-SIS) [23,24]; SF-12 [25]; Timed Up and Go (TUG) [26] and 30-s chair stand test (30sCST) [27].…”

Section: Assessmentsmentioning

confidence: 99%

Physical activity and exercise outcomes in Huntington's disease (PACE-HD): results of a 12-month trial-within-cohort feasibility study of a physical activity intervention in people with Huntington's disease

Quinn¹,

Playle²,

Drew³

et al. 2022

Parkinsonism & Related Disorders

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Section: Assessmentsmentioning

confidence: 99%

Physical activity and exercise outcomes in Huntington's disease (PACE-HD): results of a 12-month trial-within-cohort feasibility study of a physical activity intervention in people with Huntington's disease

Quinn¹,

Playle²,

Drew³

et al. 2022

Parkinsonism & Related Disorders

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Structural brain correlates of irritability and aggression in early manifest Huntington’s disease

Martínez‐Horta

Sampedro

Horta‐Barba

et al. 2020

Brain Imaging and Behavior

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Validity of irritability in Huntington's disease: A scoping review

Simpson

Dale

Theed

et al. 2019

Cortex

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To scope the literature concerning irritability in Huntington's disease to determine whether or not irritability is a valid and meaningful construct within this population. Method: A scoping literature review was conducted based on findings from a search of five databases (Academic Search Ultimate, PsycINFO, CINAHL, Scopus and Web of Science) in November 2018. From an initial return of 453 papers, 40 were found suitable for review. Results: Review of the 40 studies highlighted several aspects of irritability in people with HD which influence its validity as an independent construct in context of the disease. While various measures are used to assess irritability, a gold standard has yet to be identified and consequently irritability is assessed inconsistently across the literature. In addition, the results suggest that irritability may not reflect pathological disease processes in HD, but rather comprises a multidimensional construct which appears to be strongly associated with other psychological difficulties such as depression and anxiety. Conclusions: The current concept of irritability in people with HD continues to lack a general consensus in the clinical literature, in terms of both operationalisation and assessment. Consequently, further research is warranted in order to determine the extent to which irritability is a valid construct within the context of HD, including its associated behavioural, cognitive and affective dimensions.

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Irritability in Huntington's Disease: Factor Analysis of Snaith's Irritability Scale

Cited by 6 publications

References 46 publications

Physical activity and exercise outcomes in Huntington's disease (PACE-HD): results of a 12-month trial-within-cohort feasibility study of a physical activity intervention in people with Huntington's disease

Physical activity and exercise outcomes in Huntington's disease (PACE-HD): results of a 12-month trial-within-cohort feasibility study of a physical activity intervention in people with Huntington's disease

Structural brain correlates of irritability and aggression in early manifest Huntington’s disease

Validity of irritability in Huntington's disease: A scoping review

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