Irritable Bowel Syndrome and Gluten-Related Disorders

Usai-Satta, Paolo; Bassotti, Gabrio; Bellini, Massimo; Oppia, Francesco; Lai, Michela; Cabras, Francesco

doi:10.3390/nu12041117

Cited by 20 publications

(24 citation statements)

References 41 publications

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“…The combination of these symptoms (constipation, diarrhea, abdominal pain and abdominal bloating) could be secondary to persistent organic intestinal damage or part of a functional disorder such as irritable bowel syndrome (IBS). IBS often overlaps with CD diagnosis in a percentage ranging from 22% to 38% of CD patients [ 43 , 44 ]. In this study, however, we did not systematically evaluate the occurrence of this syndrome through a standardized questionnaire since it fell outside our aims.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Persistent Gastrointestinal Symptoms and Duodenal Histological Findings after Adequate Gluten-Free Diet: A Gray Area of Celiac Disease Management in Adult Patients

et al. 2021

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A gluten-free diet (GFD) leads to a rapid improvement in gastrointestinal (GI) symptoms, biochemical alterations and duodenal histological damage in the majority of celiac disease (CD) patients. This study aimed to assess the frequency and factors associated with the persistence of GI symptoms/malabsorption signs and their relationship with duodenal histological findings among CD patients on an adequate GFD (mean duration 16 months, range 12–28 months). This longitudinal cohort study included 102 adult CD patients (median age 38.5 years, range 18–76 years, F = 71.6%) diagnosed between 2012 and 2018. A total of 36.3% of the included patients had persistent GI symptoms and/or malabsorption signs (Group 1), while the remaining patients had complete GI well-being without malabsorption signs (Group 2) at the time of histological re-evaluation. The persistence of GI symptoms/signs was associated with a long duration of symptoms/signs before CD diagnosis (≥5 years) (OR 5.3; 95% CI 1.3–21.8) and the presence of constipation at the time of CD diagnosis (OR 7.5; 95% CI 1.3–42) while for other variables, including age at CD diagnosis, sex, duration of GFD, comorbidities, CD serology positivity and severity of duodenal damage at histological re-evaluation, no association was found. According to our results, the persistence of symptoms/signs is not associated with histological findings, and their relationship could be a gray area in CD management.

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Section: Discussionmentioning

confidence: 99%

Relationship between Persistent Gastrointestinal Symptoms and Duodenal Histological Findings after Adequate Gluten-Free Diet: A Gray Area of Celiac Disease Management in Adult Patients

et al. 2021

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“…Celiac disease prevalence can be higher in IBS-D than other IBS subtypes, but IBS symptoms can exist also in treated subjects and they reduce after a gluten-free diet [ 101 ]. Celiac disease/gluten sensitivity and IBS-D are distinct entities with some overlapping symptoms [ 102 ].…”

Section: Nutritional Protocols Used For Ibs-dmentioning

confidence: 99%

Diarrhea Predominant-Irritable Bowel Syndrome (IBS-D): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms

et al. 2021

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Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain associated with defecation or a change in bowel habits. Gut microbiota, which acts as a real organ with well-defined functions, is in a mutualistic relationship with the host, harvesting additional energy and nutrients from the diet and protecting the host from pathogens; specific alterations in its composition seem to play a crucial role in IBS pathophysiology. It is well known that diet can significantly modulate the intestinal microbiota profile but it is less known how different nutritional approach effective in IBS patients, such as the low-FODMAP diet, could be responsible of intestinal microbiota changes, thus influencing the presence of gastrointestinal (GI) symptoms. The aim of this review was to explore the effects of different nutritional protocols (e.g., traditional nutritional advice, low-FODMAP diet, gluten-free diet, etc.) on IBS-D symptoms and on intestinal microbiota variations in both IBS-D patients and healthy subjects. To date, an ideal nutritional protocol does not exist for IBS-D patients but it seems crucial to consider the effect of the different nutritional approaches on the intestinal microbiota composition to better define an efficient strategy to manage this functional disorder.

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“…A Poland-Portugal study discussed if CD and IBD are true CD and IBD or just CD-like and IBD-like diseases in common variable immunodeficiency patients [ 46 ]. In an Italian study, the conclusion was that the possible interplay between irritable bowel syndrome and GRDs represents a scientifically and clinically challenging issue [ 47 ]. Inflammatory bowel syndrome and IBD are quite frequent and are occasionally connected to CD [ 1 , 48 ].…”

Section: Suggested Causes For the Recent Increase In CD Incidencementioning

confidence: 99%

Celiac disease in the COVID-19 pandemic

Samaşcă¹,

Lerner²

2021

Journal of Translational Autoimmunity

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Background The COVID-19 pandemic has had an impact on global health. Design The impact of the COVID-19 pandemic on patients with coeliac disease was assessed in the present review. Results The incidence of coeliac disease and the problems associated with coeliac disease increased during the COVID-19 pandemic. Adherence to the diet is crucial for the patient's health and quality of life since the only approved therapy for coeliac disease is a gluten withdrawal. Conclusions A gluten-free diet should be promoted by the therapeutic team and implemented among these categories of patients.

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Irritable Bowel Syndrome and Gluten-Related Disorders

Cited by 20 publications

References 41 publications

Relationship between Persistent Gastrointestinal Symptoms and Duodenal Histological Findings after Adequate Gluten-Free Diet: A Gray Area of Celiac Disease Management in Adult Patients

Relationship between Persistent Gastrointestinal Symptoms and Duodenal Histological Findings after Adequate Gluten-Free Diet: A Gray Area of Celiac Disease Management in Adult Patients

Diarrhea Predominant-Irritable Bowel Syndrome (IBS-D): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms

Celiac disease in the COVID-19 pandemic

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